Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro (Q24656275)

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A Ogawa

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Y Shiloh

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K Tamai

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S J Elledge

Proceedings of the National Academy of Sciences of the United States of America

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language of work or name

English

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publication date

12 September 2000

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published in

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volume

97

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issue

19

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page(s)

10389-94

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cites work

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

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The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites

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A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

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Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

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Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

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Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair

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Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice

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Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

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Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216

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Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

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ATR disruption leads to chromosomal fragmentation and early embryonic lethality

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Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

7 April 2017

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Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

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The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast

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Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

7 April 2017

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Radiation-induced cell cycle arrest compromised by p21 deficiency

7 April 2017

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A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

7 April 2017

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ATM: a mediator of multiple responses to genotoxic stress

7 April 2017

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DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

28 September 2017

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Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

28 September 2017

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Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control

28 September 2017

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Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=27034

DNA damage induces phosphorylation of the amino terminus of p53

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=27034

Recombinant ATM protein complements the cellular A-T phenotype

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=27034

Episomal vectors rapidly and stably produce high-titer recombinant retrovirus

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=27034

A kinase from fission yeast responsible for blocking mitosis in S phase

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=27034

Phosphorylation of p53 serine 15 increases interaction with CBP

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10973490

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Role of human Cds1 (Chk2) kinase in DNA damage checkpoint and its regulation by p53

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10973490

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.190030497

1 reference

ADS bibcode

2000PNAS...9710389M

0 references

1 reference

1 reference

PubMed publication ID

10973490

1 reference