Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1beta (Q24656645)

2

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N Rezvani

3

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L C Loram

4

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Y Zhang

5

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S F Maier

6

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K C Rice

7

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L R Watkins

The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex

8

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language of work or name

English

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publication date

20 January 2010

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published in

Neuroscience

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volume

165

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page(s)

569-83

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issue

2

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cites work

1 reference

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Pathological and protective roles of glia in chronic pain

7 April 2017

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Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia

7 April 2017

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Evidence that opioids may have toll-like receptor 4 and MD-2 effects

7 April 2017

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Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4)

7 April 2017

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Expression of UDP-glucuronosyltransferases (UGTs) 2B7 and 1A6 in the human brain and identification of 5-hydroxytryptamine as a substrate

7 April 2017

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A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine

7 April 2017

1 reference

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Quantitative assessment of tactile allodynia in the rat paw

7 April 2017

1 reference

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A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia

7 April 2017

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Evidence for a role of heat shock protein-90 in toll like receptor 4 mediated pain enhancement in rats

7 April 2017

1 reference

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The cortical innate immune response increases local neuronal excitability leading to seizures

28 September 2017

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Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast)

28 September 2017

1 reference

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Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia

28 September 2017

1 reference

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Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid beta-peptide and the membrane lipid peroxidation product 4-hydroxynonenal

28 September 2017

1 reference

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Novel roles in human MD-2 of phenylalanines 121 and 126 and tyrosine 131 in activation of Toll-like receptor 4 by endotoxin

28 September 2017

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Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits

28 September 2017

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Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors

28 September 2017

1 reference

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The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy

28 September 2017

1 reference

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Morphine-3-glucuronide's neuro-excitatory effects are mediated via indirect activation of N-methyl-D-aspartic acid receptors: mechanistic studies in embryonic cultured hippocampal neurones

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795035

Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway

28 September 2017

1 reference

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Relationships among morphine metabolism, pain and side effects during long-term treatment: an update.

28 September 2017

1 reference

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Pathobiology of neuropathic pain

28 September 2017

1 reference

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A CD14-independent LPS receptor cluster

28 September 2017

1 reference

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Thermal hyperalgesia and mechanical allodynia produced by intrathecal administration of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein, gp120.

28 September 2017

1 reference

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Morphine derivatives with diminished opiate receptor potency show enhanced central excitatory activity

28 September 2017

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28 September 2017

1 reference

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Quantitative real-time RT-PCR assessment of spinal microglial and astrocytic activation markers in a rat model of neuropathic pain.

28 September 2017

1 reference

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Is development of hyperalgesia, allodynia and myoclonus related to morphine metabolism during long-term administration? Six case histories

30 May 2018

1 reference

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Nonspecific convulsions are induced by morphine but not D-Ala2-methionine-enkephalinamide at cortical sites

30 May 2018

1 reference

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High dose of spinal morphine produce a nonopiate receptor-mediated hyperesthesia: clinical and theoretic implications.

30 May 2018

1 reference

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Morphine-6-glucuronide: analgesic effects and receptor binding profile in rats.

30 May 2018

1 reference

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Serum and cerebrospinal fluid morphine pharmacokinetics after single doses of intravenous and intramuscular morphine after hip replacement surgery.

30 May 2018

1 reference

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Morphine in postoperative patients: pharmacokinetics and pharmacodynamics of metabolites.

28 November 2018

1 reference

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Elevated central monoamine receptor mRNA in rats bred for high endurance capacity: implications for central fatigue.

28 November 2018

1 reference

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Controlling pathological pain by adenovirally driven spinal production of the anti-inflammatory cytokine, interleukin-10.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795035

Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795035

Complete Freunds adjuvant-induced peripheral inflammation evokes glial activation and proinflammatory cytokine expression in the CNS.

28 November 2018

1 reference

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A method for measuring multiple cytokines from small samples.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795035

Intrathecal HIV-1 envelope glycoprotein gp120 induces enhanced pain states mediated by spinal cord proinflammatory cytokines.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795035

The involvement of glial cells in the development of morphine tolerance

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795035

Hydromorphone-3-glucuronide: biochemical synthesis and preliminary pharmacological evaluation.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795035

The excitatory effects of morphine-3-glucuronide are attenuated by LY274614, a competitive NMDA receptor antagonist, and by midazolam, an agonist at the benzodiazepine site on the GABAA receptor complex.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795035

Pharmacology of morphine and morphine-3-glucuronide at opioid, excitatory amino acid, GABA and glycine binding sites

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2795035

Pharmacology of the allodynia in rats evoked by high dose intrathecal morphine

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19833175

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The excitatory behavioral and antianalgesic pharmacology of normorphine-3-glucuronide after intracerebroventricular administration to rats

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19833175

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A method for increasing the viability of the external portion of lumbar catheters placed in the spinal subarachnoid space of rats

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19833175

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.NEUROSCIENCE.2009.10.011

1 reference

2218126

2218126

1 reference

1 reference

1 reference