CD4+CD28- costimulation-independent T cells in multiple sclerosis (Q24670063)

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K P Wandinger

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H F McFarland

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R Martin

Journal of Clinical Investigation

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language of work or name

English

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publication date

October 2001

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published in

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volume

108

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page(s)

1185-94

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issue

8

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cites work

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Decreased dependence of myelin basic protein-reactive T cells on CD28-mediated costimulation in multiple sclerosis patients. A marker of activated/memory T cells

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Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis

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Paradoxical inhibition of T-cell function in response to CTLA-4 blockade; heterogeneity within the human T-cell population

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Isolation of self antigen-reactive cells from inflamed islets of nonobese diabetic mice using CD4high expression as a marker.

28 November 2018

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28 November 2018

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Blockade of CD28 during in vitro activation of encephalitogenic T cells or after disease onset ameliorates experimental autoimmune encephalomyelitis

28 November 2018

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Costimulatory molecules in Wegener's granulomatosis (WG): lack of expression of CD28 and preferential up-regulation of its ligands B7-1 (CD80) and B7-2 (CD86) on T cells

28 November 2018

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Expansion of autoreactive T cells in multiple sclerosis is independent of exogenous B7 costimulation

28 November 2018

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CTLA-4 blockade enhances clinical disease and cytokine production during experimental allergic encephalomyelitis

28 November 2018

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Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement

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Adhesion molecule expression on cerebrospinal fluid T lymphocytes: evidence for common recruitment mechanisms in multiple sclerosis, aseptic meningitis, and normal controls.

28 November 2018

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Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity

28 November 2018

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Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

28 November 2018

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12 December 2020

Increased numbers of CCR5+ interferon-gamma- and tumor necrosis factor-alpha-secreting T lymphocytes in multiple sclerosis patients

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12 December 2020

Human autoreactive CD4+ T cells from naive CD45RA+ and memory CD45RO+ subsets differ with respect to epitope specificity and functional antigen avidity

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12 December 2020

Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand

1 reference

12 December 2020

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

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12 December 2020

Immunology of multiple sclerosis

1 reference

12 December 2020

CD11b+CD28-CD4+ human T cells: activation requirements and association with HLA-DR alleles

1 reference

12 December 2020

1 reference

12 December 2020

1 reference

12 December 2020

T cell growth cytokines cause the superinduction of molecules mediating antigen-induced T lymphocyte death

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12 December 2020

A very high level of crossreactivity is an essential feature of the T-cell receptor

1 reference

12 December 2020

Identifiers

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1351194

1351194

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