Hereditary pancreatitis: new insights into acute and chronic pancreatitis (Q24670166)

Identification and expression of the cDNA-encoding human mesotrypsin(ogen), an isoform of trypsin with inhibitor resistance

Europe PubMed Central

title

Hereditary pancreatitis: new insights into acute and chronic pancreatitis (English)

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D C Whitcomb

1

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language of work or name

English

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publication date

September 1999

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published in

Gut

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volume

45

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issue

3

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page(s)

317-22

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cites work

1 reference

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Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene

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Molecular cloning and nucleotide sequence of human pancreatic prechymotrypsinogen cDNA

7 April 2017

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Crystal structure of human trypsin 1: unexpected phosphorylation of Tyr151

7 April 2017

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Three-dimensional structure of the complex between pancreatic secretory trypsin inhibitor (Kazal type) and trypsinogen at 1.8 A resolution. Structure solution, crystallographic refinement and preliminary structural interpretation

7 April 2017

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Pedigree of a family with hereditary chronic relapsing pancreatitis

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Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis

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Mutations in exons 2 and 3 of the cationic trypsinogen gene in Japanese families with hereditary pancreatitis

7 April 2017

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A critical role for transforming growth factor-beta in donor transfusion-induced allograft tolerance

28 September 2017

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Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture.

28 September 2017

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Evidence for a common mutation in hereditary pancreatitis

28 September 2017

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Mutations of the cationic trypsinogen in hereditary pancreatitis

28 September 2017

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Elevated calcium and activation of trypsinogen in rat pancreatic acini

28 September 2017

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The complete 685-kilobase DNA sequence of the human beta T cell receptor locus

28 September 2017

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Pathology of acute and chronic pancreatitis.

28 September 2017

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Is an elevated concentration of acinar cytosolic free ionised calcium the trigger for acute pancreatitis?

28 September 2017

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Pancreatitis. The role of lysosomes

28 September 2017

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Hereditary pancreatitis: three new kindreds and a critical review of the literature

28 September 2017

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Activation of pancreatic zymogens. Normal activation, premature intrapancreatic activation, protective mechanisms against inappropriate activation

28 September 2017

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Immunoreactive anionic and cationic trypsin in human serum

28 September 2017

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Treatment of acute pancreatitis. Comparison of animal and human studies.

28 September 2017

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Intracellular activation of digestive zymogens in rat pancreatic acini. Stimulation by high doses of cholecystokinin

28 September 2017

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Definitions and classifications of pancreatitis.

28 September 2017

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Met 358 to Arg mutation of alpha 1-antitrypsin associated with protein C deficiency in a patient with mild bleeding tendency

28 September 2017

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Hereditary pancreatitis in England and Wales.

28 September 2017

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The two human trypsinogens: Catalytic properties of the corresponding trypsins

28 September 2017

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Diabetes mellitus and cerebrovascular disease

28 September 2017

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Immunohistochemical study of transforming growth factor-beta 1, matrix metalloproteinase-2,9, tissue inhibitors of metalloproteinase-1,2, and basement membrane components at pancreatic ducts in chronic pancreatitis.

30 May 2018

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Two mutations in rat trypsin confer resistance against autolysis.

30 May 2018

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Does acute alcoholic pancreatitis exist without preexisting chronic pancreatitis?

30 May 2018

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Linkage studies in a large kindred with hereditary pancreatitis confirms mapping of the gene to a 16-cM region on 7q.

30 May 2018

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Modeling studies of the change in conformation required for cleavage of limited proteolytic sites

30 May 2018

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Hereditary pancreatitis in a kinship associated with portal vein thrombosis

30 May 2018

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Surgical management of pancreatitis in childhood.

30 May 2018

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Pseudocyst formation in hereditary pancreatitis

30 May 2018

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Two human trypsinogens. Purification, molecular properties, and N-terminal sequences

30 May 2018

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30 May 2018

Genes means pancreatitis

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Identification, culture, and characterization of pancreatic stellate cells in rats and humans.

28 November 2018

1 reference

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Course of alcoholic chronic pancreatitis: a prospective clinicomorphological long-term study

28 November 2018

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12 December 2020

Acute pancreatitis is not a cause of chronic pancreatitis in the absence of residual duct strictures

1 reference

12 December 2020

An exceptional genealogy for hereditary chronic pancreatitis

1 reference

12 December 2020

Heterogeneity in hereditary pancreatitis

1 reference

12 December 2020

A gene for hereditary pancreatitis maps to chromosome 7q35

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12 December 2020

The activation of trypsinogen by cathepsin B

1 reference

12 December 2020

Proliferation kinetics of macrophage subpopulations in a rat experimental pancreatitis model

1 reference

12 December 2020

Clinical characteristics of hereditary pancreatitis in a large family, based on high-risk haplotype. The Midwest Multicenter Pancreatic Study Group (MMPSG)

1 reference

12 December 2020

Premature trypsin activation in hereditary pancreatitis

1 reference

12 December 2020

Possible lysosomal activation of pancreatic zymogens. Activation of both human trypsinogens by cathepsin B and spontaneous acid. Activation of human trypsinogen 1

1 reference

12 December 2020

The hereditary pancreatitis gene maps to long arm of chromosome 7

1 reference

12 December 2020

Localization of transforming growth factor beta 1 and its latent binding protein in human chronic pancreatitis

1 reference

12 December 2020

Acute hypercalcemia causes acute pancreatitis and ectopic trypsinogen activation in the rat

1 reference

12 December 2020

Acute hemorrhagic pancreatic necrosis in mice. Intraparenchymal activation of zymogens, and other enzyme changes in pancreas and serum

1 reference

12 December 2020

Genotype and phenotype in cystic fibrosis

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12 December 2020

Pseudocysts in chronic pancreatitis: a morphological analysis of 57 resection specimens and 9 autopsy pancreata

1 reference

12 December 2020

Chronic relapsing pancreatitis. A study of twenty-nine cases without associated disease of the biliary or gastro-intestinal tract

1 reference

12 December 2020

Proteolysis of human trypsinogen 1. Pathogenic implication in chronic pancreatitis

1 reference

12 December 2020

Pancreatitis and mutations of the cystic fibrosis gene

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12 December 2020

Comparative studies on the mechanism of activation of the two human trypsinogens

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12 December 2020

New chronic pancreatitis model with diabetes induced by cerulein plus stress in rats

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12 December 2020

Early trypsinogen activation in acute pancreatitis

1 reference

12 December 2020

The First International Symposium on Hereditary Pancreatitis

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12 December 2020

Hereditary pancreatitis

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12 December 2020

New concepts in understanding the pathophysiology of chronic pancreatitis

1 reference

12 December 2020

Diagnose einer »hereditären Pankreatitis« durch Nachweis der Mutation im kationischen Trypsinogen-Gen

1 reference

12 December 2020