Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity (Q24670363)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12486102%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

title

Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity (English)

1 reference

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15 December 2019

8

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15 December 2019

author name string

Margaret L Hibbs

1

1 reference

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15 December 2019

Kenneth W Harder

2

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15 December 2019

Jane Armes

3

1 reference

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15 December 2019

Nicole Kountouri

4

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15 December 2019

Cathy Quilici

5

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15 December 2019

Franca Casagranda

6

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15 December 2019

Ashley R Dunn

7

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15 December 2019

language of work or name

English

0 references

publication date

1 December 2002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12486102%20AND%20SRC:MED&resulttype=core&format=json

Journal of Experimental Medicine

15 December 2019

published in

1 reference

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15 December 2019

volume

196

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15 December 2019

issue

12

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15 December 2019

page(s)

1593-1604

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A double-edged kinase Lyn: a positive and negative regulator for antigen receptor-mediated signals

15 December 2019

cites work

1 reference

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Inhibition of the B cell by CD22: a requirement for Lyn

7 April 2017

1 reference

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Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage

7 April 2017

1 reference

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Stem cell factor induces phosphatidylinositol 3'-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196073

Src homology region 2 (SH2) domain-containing phosphatase-1 dephosphorylates B cell linker protein/SH2 domain leukocyte protein of 65 kDa and selectively regulates c-Jun NH2-terminal kinase activation in B cells

7 April 2017

1 reference

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Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor

7 April 2017

1 reference

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Paired immunoglobulin-like receptor B (PIR-B) inhibits BCR-induced activation of Syk and Btk by SHP-1

7 April 2017

1 reference

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Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196073

Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection

7 April 2017

1 reference

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CD22 is a negative regulator of B-cell receptor signalling

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196073

Hyperresponsive B cells in CD22-deficient mice

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196073

Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196073

Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196073

Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45

7 April 2017

1 reference

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Proximal protein tyrosine kinases in immunoreceptor signaling

7 April 2017

1 reference

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Generation, expansion, migration and activation of mouse B1 cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196073

Regulation of B-cell activation and differentiation by the phosphatidylinositol 3-kinase and phospholipase Cgamma pathway

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196073

Cytoplasmic protein tyrosine phosphatases SHP-1 and SHP-2: regulators of B cell signal transduction.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196073

Constitutive tyrosine phosphorylation of the inhibitory paired Ig-like receptor PIR-B.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196073

Regulation of B cell antigen receptor signaling by the Lyn/CD22/SHP1 pathway.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196073

Signal transduction from the B cell antigen-receptor

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196073

MFR, a putative receptor mediating the fusion of macrophages

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196073

Positive versus negative signaling by lymphocyte antigen receptors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196073

CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196073

Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fc(gamma)RIIB.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196073

The regulation of self-reactive B cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196073

The fate of self-reactive B cells depends primarily on the degree of antigen receptor engagement and availability of T cell help.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196073

Distinctive developmental origins and specificities of murine CD5+ B cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196073

Anergic self-reactive B cells present self antigen and respond normally to CD40-dependent T-cell signals but are defective in antigen-receptor-mediated functions.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196073

Clonal anergy: persistence in tolerant mice of antigen-binding B lymphocytes incapable of responding to antigen or mitogen

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196073

Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196073

Characterization of murine colony-forming B cells. I. Distribution, resistance to anti-immunoglobulin antibodies, and expression of Ia antigens

28 September 2017

1 reference

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Motheaten, an immunodeficient mutant of the mouse. II. Depressed immune competence and elevated serum immunoglobulins

28 September 2017

1 reference

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Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.

28 September 2017

1 reference

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The unique antigen receptor signaling phenotype of B-1 cells is influenced by locale but induced by antigen

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196073

The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196073

Different nuclear signals are activated by the B cell receptor during positive versus negative signaling.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196073

Bcl-2 increases memory B cell recruitment but does not perturb selection in germinal centers.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196073

Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2196073

Functional and molecular characterization of single, (4-hydroxy-3-nitrophenyl)acetyl (NP)-specific, IgG1+ B cells from antibody-secreting and memory B cell pathways in the C57BL/6 immune response to NP.

30 May 2018

1 reference

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CD22 regulates thymus-independent responses and the lifespan of B cells.

30 May 2018

1 reference

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CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice.

19 June 2018

1 reference

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Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene.

21 January 2018

1 reference

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Heterotrimeric G protein signaling: roles in immune function and fine-tuning by RGS proteins

21 January 2018

1 reference

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Antigen-induced exclusion from follicles and anergy are separate and complementary processes that influence peripheral B cell fate

21 January 2018

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The site and stage of anti-DNA B-cell deletion.

21 January 2018

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Reduced life span of anergic self-reactive B cells in a double-transgenic model

21 January 2018

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Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells

21 January 2018

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Expansion and functional activity of Ly-1+ B cells upon transfer of peritoneal cells into allotype-congenic, newborn mice

21 January 2018

1 reference

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Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

21 January 2018

1 reference

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Induction of self-tolerance in mature peripheral B lymphocytes

21 January 2018

1 reference

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Spontaneous autoimmune disease in Fc(gamma)RIIB-deficient mice results from strain-specific epistasis

21 January 2018

1 reference

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Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene

21 January 2018

1 reference

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Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease

21 January 2018

1 reference

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Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice

21 January 2018

1 reference

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Novel roles for Lyn in B cell migration and lipopolysaccharide responsiveness revealed using anti-double-stranded DNA Ig transgenic mice

21 January 2018

1 reference

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Development and follicular localization of tolerant B lymphocytes in lysozyme/anti-lysozyme IgM/IgD transgenic mice

21 January 2018

1 reference

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Expression of a bcl-2 transgene reduces proliferation and slows turnover of developing B lymphocytes in vivo

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12486102

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Genetic evidence for Lyn as a negative regulator of IL-4 signaling

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12486102

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1084/JEM.20020515

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12486102%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12486102%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

2 references