Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor (Q24673178)

2

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S Boyce

3

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C Brideau

4

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S Charleson

5

0 references

W Cromlish

6

0 references

D Ethier

7

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J Evans

8

0 references

J P Falgueyret

9

0 references

A W Ford-Hutchinson

10

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R Gordon

11

0 references

G Greig

12

0 references

M Gresser

13

0 references

J Guay

14

0 references

S Kargman

15

0 references

S Léger

16

0 references

J A Mancini

17

0 references

G O'Neill

18

0 references

M Ouellet

19

0 references

I W Rodger

20

0 references

M Thérien

21

0 references

Z Wang

22

0 references

J K Webb

23

0 references

E Wong

24

0 references

C C Chan

British Journal of Pharmacology

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language of work or name

English

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publication date

May 1997

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published in

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volume

121

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issue

1

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page(s)

105-17

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cites work

Gastrointestinal damage associated with the use of nonsteroidal antiinflammatory drugs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

A human whole blood assay for clinical evaluation of biochemical efficacy of cyclooxygenase inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

Comparison of the systemic inhibition of thromboxane synthesis, anti-inflammatory activity and gastro-intestinal toxicity of non-steroidal anti-inflammatory drugs in the rat

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

Antinociceptive effects of non-steroidal anti-inflammatory drugs in a rat model of unilateral hindpaw inflammation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

Mechanism of selective inhibition of the inducible isoform of prostaglandin G/H synthase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

High-level expression of active human cyclooxygenase-2 in insect cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

Anti-inflammatory, analgesic, antipyretic and related properties of meloxicam, a new non-steroidal anti-inflammatory agent with favourable gastrointestinal tolerance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

Meloxicam: influence on arachidonic acid metabolism. Part 1. In vitro findings

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

Selective inhibition of NS-398 on prostanoid production in inflamed tissue in rat carrageenan-air-pouch inflammation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

Etodolac selectively inhibits human prostaglandin G/H synthase 2 (PGHS-2) versus human PGHS-1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

Constitutive cyclooxygenase (COX-1) and inducible cyclooxygenase (COX-2): rationale for selective inhibition and progress to date

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

Role of prostaglandin H synthase-2 in prostaglandin E2 formation in rat carrageenin-induced pleurisy.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

The kinetic factors that determine the affinity and selectivity for slow binding inhibition of human prostaglandin H synthase 1 and 2 by indomethacin and flurbiprofen

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

Prostaglandin synthase 2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

Characterization of Prostaglandin G/H Synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

Selective inhibition of cyclooxygenase 2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

A randomized double-blind comparison of placebo, etodolac, and naproxen on gastrointestinal injury and prostaglandin production

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

Novel terphenyls as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

The effect of nimesulide on prostanoid formation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

Renal toxicity of the nonsteroidal anti-inflammatory drugs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

1 reference

7 January 2021

Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

Purification and characterization of recombinant human cyclooxygenase-2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

Selective cyclooxygenase inhibitors: novel 1,2-diarylcyclopentenes are potent and orally active COX-2 inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

Structural requirements for time-dependent inhibition of prostaglandin biosynthesis by anti-inflammatory drugs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

New insights into the mode of action of anti-inflammatory drugs.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

The 1994 Merck Frosst Award. Mechanisms of nonsteroidal anti-inflammatory drug (NSAID) induced gastrointestinal damage--potential for development of gastrointestinal tract safe NSAIDs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

The pharmacological profile of CGP 28238, a highly potent anti-inflammatory compound

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

Antiinflammatory 4,5-diarylpyrroles. 2. Activity as a function of cyclooxygenase-2 inhibition

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

Human whole blood assays for inhibition of prostaglandin G/H synthases-1 and -2 using A23187 and lipopolysaccharide stimulation of thromboxane B2 production

1 reference

https://api.crossref.org/works/10.1038%2FSJ.BJP.0701076

7 January 2021

Identifiers

DOI

10.1038/SJ.BJP.0701076

1 reference

2094997

2094997

1 reference

1 reference

1 reference