Attenuation of cardiac fibrosis by pirfenidone and amiloride in DOCA-salt hypertensive rats (Q24673267)

2

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Andrew Fenning

3

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Anna Strachan

4

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Solomon B Margolin

5

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Stephen M Taylor

6

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Lindsay Brown

British Journal of Pharmacology

7

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language of work or name

English

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publication date

February 2002

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published in

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volume

135

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issue

4

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page(s)

961-8

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cites work

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Dietary intake of pirfenidone ameliorates bleomycin-induced lung fibrosis in hamsters

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Anti-inflammatory effect of pirfenidone in the bleomycin-hamster model of lung inflammation

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Effects of pirfenidone on transforming growth factor-beta gene expression at the transcriptional level in bleomycin hamster model of lung fibrosis

30 May 2018

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Pirfenidone attenuates bleomycin-induced changes in pulmonary functions in hamsters

30 May 2018

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Compensated cardiac hypertrophy: arrhythmogenicity and the new myocardial phenotype. I. Fibrosis

30 May 2018

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Amiloride analogues induce responses in isolated rat cardiovascular tissues by inhibition of Na+/Ca2+ exchange

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Impaired diastolic function and coronary reserve in genetic hypertension. Role of interstitial fibrosis and medial thickening of intramyocardial coronary arteries

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Reduction in myocardial collagen cross-linking parallels left ventricular dilatation in rat models of systolic chamber dysfunction

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Reduction in Left Ventricular Messenger RNA for Transforming Growth Factor β 1 Attenuates Left Ventricular Fibrosis and Improves Survival Without Lowering Blood Pressure in the Hypertensive TGR(mRen2)27 Rat

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Modulation of airway remodeling-associated mediators by the antifibrotic compound, pirfenidone, and the matrix metalloproteinase inhibitor, batimastat, during acute lung injury in mice

21 January 2018

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A phase II trial of pirfenidone (5-methyl-1-phenyl-2-[1H]-pyridone), a novel anti-fibrosing agent, in myelofibrosis with myeloid metaplasia

28 November 2018

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Pirfenidone inhibits dimethylnitrosamine-induced hepatic fibrosis in rats

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Prevention of Cardiac Necrosis by Amiloride

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Comparison of inotropic and chronotropic responses in rat isolated atria and ventricles

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Myocardial fibrosis in the rat with mineralocorticoid excess. Prevention of scarring by amiloride

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Increased cardiac types I and III collagen mRNAs in aldosterone-salt hypertension

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Collagen metabolism in cultured adult rat cardiac fibroblasts: response to angiotensin II and aldosterone

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Determinants of cardiac fibrosis in experimental hypermineralocorticoid states

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Pirfenidone prevents collagen accumulation in the remnant kidney in rats with partial nephrectomy

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Energy metabolism and mechanical recovery after cardioplegia in moderately hypertrophied rats

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Rat models of hypertension, cardiac hypertrophy and failure

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Reversal of cardiac fibrosis in deoxycorticosterone acetate-salt hypertensive rats by inhibition of the renin-angiotensin system

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Lisinopril-mediated regression of myocardial fibrosis in patients with hypertensive heart disease

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12 December 2020