The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Galpha-interaction face (Q24673940)

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2 January 2020

title

The RGS protein inhibitor CCG-4986 is a covalent modifier of the RGS4 Galpha-interaction face (English)

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2 January 2020

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6

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2 January 2020

author name string

Adam J Kimple

1

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2 January 2020

Francis S Willard

2

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2 January 2020

Patrick M Giguère

3

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2 January 2020

Christopher A Johnston

4

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2 January 2020

Viorel Mocanu

5

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2 January 2020

language of work or name

English

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publication date

29 June 2007

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Biochimica et Biophysica Acta

2 January 2020

published in

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2 January 2020

volume

1774

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2 January 2020

issue

9

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2 January 2020

page(s)

1213-1220

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The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits

2 January 2020

cites work

1 reference

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NMR structure of free RGS4 reveals an induced conformational change upon binding Galpha

7 April 2017

1 reference

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Solution structure of human GAIP (Galpha interacting protein): a regulator of G protein signaling

7 April 2017

1 reference

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Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis

7 April 2017

1 reference

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Improved methods for building protein models in electron density maps and the location of errors in these models

7 April 2017

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How many drug targets are there?

7 April 2017

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Identification of small-molecule inhibitors of RGS4 using a high-throughput flow cytometry protein interaction assay

7 April 2017

1 reference

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Chemical genetics reveals an RGS/G-protein role in the action of a compound

7 April 2017

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Clopidogrel and ticlopidine: P2Y12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis

7 April 2017

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GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins

7 April 2017

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GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits

7 April 2017

1 reference

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A new family of regulators of G-protein-coupled receptors?

7 April 2017

1 reference

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A new vector for high-throughput, ligation-independent cloning encoding a tobacco etch virus protease cleavage site

7 April 2017

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G-protein signaling: back to the future

7 April 2017

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Regulators of G protein signaling & drugs of abuse.

28 September 2017

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RIC-8 is required for GPR-1/2-dependent Galpha function during asymmetric division of C. elegans embryos

28 September 2017

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Fluorescence-based assays for RGS box function

28 September 2017

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The G betagamma dimer as a novel source of selectivity in G-protein signaling: GGL-ing at convention.

28 September 2017

1 reference

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RGS proteins: G protein-coupled receptors meet their match

28 September 2017

1 reference

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Regulators of G-protein signalling as new central nervous system drug targets.

28 September 2017

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Aspirin and human platelets: from clinical trials to acetylation of cyclooxygenase and back

28 September 2017

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A direct fluorescence-based assay for RGS domain GTPase accelerating activity

28 September 2017

1 reference

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The GTPase-activating protein RGS4 stabilizes the transition state for nucleotide hydrolysis

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17660054

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Differential G-alpha interaction capacities of the GoLoco motifs in Rap GTPase activating proteins

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17660054

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.BBAPAP.2007.06.002

1 reference

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2 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17660054%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

PubMed publication ID

17660054

1 reference