Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism (Q24674309)

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English	Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism	scientific article

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scholarly article

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Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism (English)

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author name string

D M O'Leary

1

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V Movsesyan

2

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S Vicini

3

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A I Faden

4

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language of work or name

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publication date

December 2000

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British Journal of Pharmacology

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131

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7

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1429-37

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2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572472

7 April 2017

SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572472

7 April 2017

Neuroprotective effects of group III mGluR in traumatic neuronal injury

1 reference

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7 April 2017

Activation of metabotropic glutamate receptors coupled to inositol phospholipid hydrolysis amplifies NMDA-induced neuronal degeneration in cultured cortical cells

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The metabotropic glutamate receptors: structure and functions

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7 April 2017

Pharmacology and functions of metabotropic glutamate receptors

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7 April 2017

Pharmacological agents acting at subtypes of metabotropic glutamate receptors

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28 September 2017

Factors affecting excitatory amino acid release following severe human head injury

1 reference

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28 September 2017

New in vitro model of traumatic neuronal injury: evaluation of secondary injury and glutamate receptor-mediated neurotoxicity

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Comparing the role of metabotropic glutamate receptors in long-term potentiation and in learning and memory

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Metabotropic glutamate receptors: a new target for the therapy of neurodegenerative disorders?

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Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1.

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Metabotropic glutamate receptors: novel targets for drug development

1 reference

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N-methyl-D-aspartate antagonist MK801 improves outcome following traumatic spinal cord injury in rats: behavioral, anatomic, and neurochemical studies

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Massive increases in extracellular potassium and the indiscriminate release of glutamate following concussive brain injury

1 reference

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28 September 2017

Mechanical injury to neuronal/glial cultures in microplates: role of NMDA receptors and pH in secondary neuronal cell death.

1 reference

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30 May 2018

mGluR modulation of post-traumatic neuronal death: role of NMDA receptors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572472

30 May 2018

Cloning and expression of rat metabotropic glutamate receptor 8 reveals a distinct pharmacological profile.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572472

30 May 2018

Activation of group III metabotropic glutamate receptors is neuroprotective in cortical cultures.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572472

30 May 2018

Metabotropic glutamate antagonist, MCPG, treatment of traumatic brain injury in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572472

30 May 2018

Pharmacological analysis of 4-carboxyphenylglycine derivatives: comparison of effects on mGluR1 alpha and mGluR5a subtypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572472

30 May 2018

Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572472

30 May 2018

Pretreatment with NMDA antagonists limits release of excitatory amino acids following traumatic brain injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572472

30 May 2018

Metabotropic glutamate receptor activation and blockade: their role in long-term potentiation, learning and neurotoxicity.

1 reference

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28 November 2018

Role of Group I Metabotropic Glutamate Receptors in Traumatic Spinal Cord White Matter Injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572472

28 November 2018

Antagonists for group I mGluRs attenuate excitotoxic neuronal death in cortical cultures.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572472

28 November 2018

Activation of metabotropic glutamate receptor subtype mGluR1 contributes to post-traumatic neuronal injury.

1 reference

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28 November 2018

The effect of NMDA, AMPA/kainate, and calcium channel antagonists on traumatic cortical neuronal injury in culture.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1572472

28 November 2018

The role of excitatory amino acids and NMDA receptors in traumatic brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/11090117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Excitatory and inhibitory amino acids and peptide-induced responses in acutely isolated rat spinal dorsal horn neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/11090117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3,5-dihydroxyphenylglycine is a highly selective agonist for phosphoinositide-linked metabotropic glutamate receptors in the rat hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/11090117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabotropic glutamate receptors: electrophysiological properties and role in plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11090117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 r

1 reference

https://pubmed.ncbi.nlm.nih.gov/11090117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phenylglycine derivatives discriminate between mGluR1- and mGluR5-mediated responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/11090117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Latest eruptions in metabotropic glutamate receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11090117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(RS)-2-chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but no mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/11090117

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/SJ.BJP.0703715

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