Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin L (Q24678337)

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V Stoka

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G Pungercic

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I Dolenc

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V Turk

Journal of Experimental Medicine

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language of work or name

English

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publication date

1 April 1996

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published in

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volume

183

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issue

4

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page(s)

1331-8

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cites work

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The segment of invariant chain that is critical for association with major histocompatibility complex class II molecules contains the sequence of a peptide eluted from class II polypeptides

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The chondroitin sulfate form of invariant chain can enhance stimulation of T cell responses through interaction with CD44.

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Proteolysis of the class II-associated invariant chain generates a peptide binding site in intracellular HLA-DR molecules

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Invariant chain can function as a chaperone protein for class II major histocompatibility complex molecules

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Delivery of nascent MHC class II-invariant chain complexes to lysosomal compartments and proteolysis of invariant chain by cysteine proteases precedes peptide binding in B-lymphoblastoid cells

28 September 2017

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Invariant chain induces a delayed transport from early to late endosomes

28 September 2017

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Transport properties of free and MHC class II-associated oligomers containing different isoforms of human invariant chain

28 September 2017

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Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding

30 May 2018

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The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route

30 May 2018

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Cathepsin B cleavage of Ii from class II MHC alpha- and beta-chains

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Invariant chain influences the immunological recognition of MHC class II molecules

30 May 2018

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Antigen presentation enhanced by the alternatively spliced invariant chain gene product p41.

30 May 2018

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In vivo competition between self peptides and foreign antigens in T-cell activation

28 November 2018

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12 December 2020

Effect of metabolic alterations on the density and the contents of cathepsins B, H and L of lysosomes in rat macrophages

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12 December 2020

Destructive proteolysis by cysteine proteases in antigen presentation of ovalbumin

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12 December 2020

Kinetics of the pH-induced inactivation of human cathepsin L

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12 December 2020

Participation of cathepsin B in processing of antigen presentation to MHC class II

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12 December 2020

Purification of the complex of cathepsin L and the MHC class II-associated invariant chain fragment from human kidney

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12 December 2020

Cathepsin D: rapid isolation by affinity chromatography on haemoglobin-agarose resin

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12 December 2020

Immunological significances of invariant chain from the aspect of its structural homology with the cystatin family

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12 December 2020