Identification of a unique core domain of par-4 sufficient for selective apoptosis induction in cancer cells (Q24679137)

2

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Sushma Gurumurthy

3

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Ravshan Burikhanov

4

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Vivek M Rangnekar

Molecular and Cellular Biology

5

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language of work or name

English

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publication date

August 2003

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published in

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volume

23

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page(s)

5516-25

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issue

16

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cites work

p62 forms a ternary complex with PKCzeta and PAR-4 and antagonizes PAR-4-induced PKCzeta inhibition

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Par-4 drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression

7 April 2017

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7 April 2017

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A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1

7 April 2017

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Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor

7 April 2017

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A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain

7 April 2017

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Aberrant rel/nfkb genes and activity in human cancer

7 April 2017

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The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C

7 April 2017

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Evidence for the involvement of Par-4 in ischemic neuron cell death

7 April 2017

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Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosis

7 April 2017

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Prostate apoptosis response-4 production in synaptic compartments following apoptotic and excitotoxic insults: evidence for a pivotal role in mitochondrial dysfunction and neuronal degeneration

7 April 2017

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Immunohistochemical analysis of the proapoptotic protein Par-4 in normal rat tissues

7 April 2017

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Par-4 transcriptionally regulates Bcl-2 through a WT1-binding site on the bcl-2 promoter

7 April 2017

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Apoptosis by Par-4 in cancer and neurodegenerative diseases

28 September 2017

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Apoptosis: a link between cancer genetics and chemotherapy

28 September 2017

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pH-induced folding of an apoptotic coiled coil

28 September 2017

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The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression

28 September 2017

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Mapping of the human PAWR (par-4) gene to chromosome 12q21.

28 September 2017

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Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras.

28 September 2017

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Positioning atypical protein kinase C isoforms in the UV-induced apoptotic signaling cascade

28 September 2017

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Expression and function of the leucine zipper protein Par-4 in apoptosis

28 September 2017

1 reference

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Commonality of the gene programs induced by effectors of apoptosis in androgen-dependent and -independent prostate cells.

28 September 2017

1 reference

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Oncogenic Ras sensitizes cells to apoptosis by Par-4.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=166354

Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease.

30 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=166354

A novel domain within the 55 kd TNF receptor signals cell death

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=166354

A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=166354

Role of protein kinase C zeta isoform in Fas resistance of immature myeloid KG1a leukemic cells.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=166354

Inactivation of the inhibitory kappaB protein kinase/nuclear factor kappaB pathway by Par-4 expression potentiates tumor necrosis factor alpha-induced apoptosis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=166354

The prostate apoptosis response-4 protein participates in motor neuron degeneration in amyotrophic lateral sclerosis

28 November 2018

1 reference

12 December 2020

Participation of par-4 in the degeneration of striatal neurons induced by metabolic compromise with 3-nitropropionic acid

1 reference

12 December 2020

Identification of two common regions of allelic loss in chromosome arm 12q in human pancreatic cancer

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12 December 2020

Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis

1 reference

12 December 2020

Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma

1 reference

12 December 2020