K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association (Q24684879)

2

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Ruiwu Wang

3

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Wenqian Chen

4

0 references

Jeff Bolstad

5

0 references

Keyun Chen

6

0 references

Yakhin Shimoni

7

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S R Wayne Chen

Ryanodine receptor mutations associated with stress-induced ventricular tachycardia mediate increased calcium release in stimulated cardiomyocytes

8

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language of work or name

English

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publication date

15 June 2007

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published in

Biochemical Journal

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volume

404

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issue

3

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page(s)

431-8

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cites work

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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Enhanced store overload-induced Ca2+ release and channel sensitivity to luminal Ca2+ activation are common defects of RyR2 mutations linked to ventricular tachycardia and sudden death

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RyR2 mutations linked to ventricular tachycardia and sudden death reduce the threshold for store-overload-induced Ca2+ release (SOICR)

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Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy.

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Characterization of Recombinant Skeletal Muscle (Ser-2843) and Cardiac Muscle (Ser-2809) Ryanodine Receptor Phosphorylation Mutants

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Cellular calcium fluctuations in mammalian heart: direct evidence from noise analysis of aequorin signals in Purkinje fibers

28 September 2017

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Characterization of a novel PKA phosphorylation site, serine-2030, reveals no PKA hyperphosphorylation of the cardiac ryanodine receptor in canine heart failure.

30 May 2018

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Gender-dependent attenuation of cardiac potassium currents in type 2 diabetic db/db mice

28 November 2018

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FKBP12.6-mediated stabilization of calcium-release channel (ryanodine receptor) as a novel therapeutic strategy against heart failure

28 November 2018

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Abnormal Ca2+ release, but normal ryanodine receptors, in canine and human heart failure

28 November 2018

1 reference

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A new cardioprotective agent, JTV519, improves defective channel gating of ryanodine receptor in heart failure

28 November 2018

1 reference

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Protective effect of JTV519, a new 1,4-benzothiazepine derivative, on prolonged myocardial preservation.

28 November 2018

1 reference

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Altered interaction of FKBP12.6 with ryanodine receptor as a cause of abnormal Ca(2+) release in heart failure

28 November 2018

1 reference

12 December 2020

Antiarrhythmic effects of JTV-519, a novel cardioprotective drug, on atrial fibrillation/flutter in a canine sterile pericarditis model

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12 December 2020

Arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia: insights from a RyR2 R4496C knock-in mouse model

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12 December 2020

The cardioprotective effects of a new 1,4-benzothiazepine derivative, JTV519, on ischemia/reperfusion-induced Ca2+ overload in isolated rat hearts

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12 December 2020