Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region (Q24685870)

ChEBI release 2020-05-28

N Kudo

1

N

Kudo

1 reference

19 October 2023

N Matsumori

2

N

Matsumori

1 reference

19 October 2023

M Yoshida

7

M

Yoshida

1 reference

19 October 2023

H Taoka

3

H

Taoka

1 reference

19 October 2023

D Fujiwara

4

D

Fujiwara

1 reference

19 October 2023

E P Schreiner

5

E P

Schreiner

1 reference

19 October 2023

B Wolff

6

B

Wolff

1 reference

19 October 2023

S Horinouchi

8

S

Proceedings of the National Academy of Sciences of the United States of America

Horinouchi

1 reference

19 October 2023

language of work or name

English

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publication date

3 August 1999

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published in

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volume

96

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issue

16

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page(s)

9112-7

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cites work

Molecular cloning and cell cycle-dependent expression of mammalian CRM1, a protein involved in nuclear export of proteins

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A novel class of RanGTP binding proteins

7 April 2017

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The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88

7 April 2017

1 reference

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Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins

7 April 2017

1 reference

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Transformation of intact yeast cells treated with alkali cations

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17741

CRM1 is an export receptor for leucine-rich nuclear export signals

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17741

The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17741

Exportin 1 (Crm1p) is an essential nuclear export factor

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17741

Nucleocytoplasmic transport: the soluble phase

7 April 2017

1 reference

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The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17741

Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17741

The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17741

Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17741

CRM1 is responsible for intracellular transport mediated by the nuclear export signal

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17741

Evidence for a role of CRM1 in signal-mediated nuclear protein export

7 April 2017

1 reference

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Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17741

Distinct functions for the two importin subunits in nuclear protein import

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17741

A cytosolic activity distinct from crm1 mediates nuclear export of protein kinase inhibitor in permeabilized cells.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17741

Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17741

Higher order chromosome structure is affected by cold-sensitive mutations in a Schizosaccharomyces pombe gene crm1+ which encodes a 115-kD protein preferentially localized in the nucleus and its periphery

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17741

Effects of leptomycin B on the cell cycle of fibroblasts and fission yeast cells

28 September 2017

1 reference

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Mutational definition of the human immunodeficiency virus type 1 Rev activation domain.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17741

Fission yeast pap1-dependent transcription is negatively regulated by an essential nuclear protein, crm1

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17741

Transport routes through the nuclear pore complex.

30 May 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.96.16.9112

A Novel Nuclear Export Signal Sensitive to Oxidative Stress in the Fission Yeast Transcription Factor Pap1

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.96.16.9112

Functional dissection of the HIV-1 Rev trans-activator—Derivation of a trans-dominant repressor of Rev function

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.96.16.9112

Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation, purification and characterization.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=17741

Caffeine-resistance in fission yeast is caused by mutations in a single essential gene, crm1+

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10430904

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.96.16.9112

1 reference

2381790

ADS bibcode

1999PNAS...96.9112K

0 references

2381790

1 reference

1 reference

1 reference