The PEST sequence does not contribute to the stability of the cystic fibrosis transmembrane conductance regulator (Q24791598)

5 July 2017

title

The PEST sequence does not contribute to the stability of the cystic fibrosis transmembrane conductance regulator (English)

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5 July 2017

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transmembrane protein

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author name string

Eva Y Chen

series ordinal

1

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5 July 2017

David M Clarke

series ordinal

2

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5 July 2017

language of work or name

English

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publication date

2 October 2002

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5 July 2017

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5 July 2017

volume

3

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5 July 2017

issue

1

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page(s)

29

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Covalent modification of the homeodomain-interacting protein kinase 2 (HIPK2) by the ubiquitin-like protein SUMO-1

5 July 2017

cites work

1 reference

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Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome

7 April 2017

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The mechanism underlying cystic fibrosis transmembrane conductance regulator transport from the endoplasmic reticulum to the proteasome includes Sec61beta and a cytosolic, deglycosylated intermediary

7 April 2017

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A novel, specific interaction involving the Csk SH3 domain and its natural ligand

7 April 2017

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7 April 2017

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High-efficiency transformation of mammalian cells by plasmid DNA

7 April 2017

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Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA

7 April 2017

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Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

7 April 2017

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Participation of the endoplasmic reticulum chaperone calnexin (p88, IP90) in the biogenesis of the cystic fibrosis transmembrane conductance regulator

7 April 2017

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Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis

7 April 2017

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The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation

7 April 2017

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PEST sequences and regulation by proteolysis

7 April 2017

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The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B

7 April 2017

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Degradation of CFTR by the ubiquitin-proteasome pathway

7 April 2017

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A role for mammalian Ubc6 homologues in ER-associated protein degradation.

7 April 2017

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Introduction of the most common cystic fibrosis mutation (Delta F508) into human P-glycoprotein disrupts packing of the transmembrane segments.

28 September 2017

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Elusive recognition determinants for ubiquitination

28 September 2017

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A principal role for the proteasome in endoplasmic reticulum-associated degradation of misfolded intracellular cystic fibrosis transmembrane conductance regulator

28 September 2017

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Cystic fibrosis: a brief look at some highlights of a decade of research focused on elucidating and correcting the molecular basis of the disease

28 September 2017

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Covalent attachment of the SUMO-1 protein to the negative regulatory domain of the c-Myb transcription factor modifies its stability and transactivation capacity

28 September 2017

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Hsp70 molecular chaperone facilitates endoplasmic reticulum-associated protein degradation of cystic fibrosis transmembrane conductance regulator in yeast

28 September 2017

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Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by its R domain

28 September 2017

1 reference

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Severed channels probe regulation of gating of cystic fibrosis transmembrane conductance regulator by its cytoplasmic domains

28 September 2017

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A functional R domain from cystic fibrosis transmembrane conductance regulator is predominantly unstructured in solution

28 September 2017

1 reference

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Cystic fibrosis transmembrane conductance regulator has an altered structure when its maturation is inhibited

28 September 2017

1 reference

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Conformation, independent of charge, in the R domain affects cystic fibrosis transmembrane conductance regulator channel openings

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=130031

Proteolysis and the cell cycle: with this RING I do thee destroy

28 September 2017

1 reference

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Cystic fibrosis as a disease of misprocessing of the cystic fibrosis transmembrane conductance regulator glycoprotein

28 September 2017

1 reference

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Quality control by proteases in the endoplasmic reticulum. Removal of a protease-sensitive site enhances expression of human P-glycoprotein.

28 September 2017

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Efficient expression of CFTR function with adeno-associated virus vectors that carry shortened CFTR genes

28 September 2017

1 reference

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Superfolding of the partially unfolded core-glycosylated intermediate of human P-glycoprotein into the mature enzyme is promoted by substrate-induced transmembrane domain interactions.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=130031

Function of the R domain in the cystic fibrosis transmembrane conductance regulator chloride channel

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=130031

Cytoplasmic loop three of cystic fibrosis transmembrane conductance regulator contributes to regulation of chloride channel activity.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=130031

Cystic fibrosis gene encodes a cAMP-dependent chloride channel in heart

28 September 2017

1 reference

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Functional consequences of proline mutations in the predicted transmembrane domain of P-glycoprotein

28 September 2017

1 reference

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Microinjected ribonuclease A as a probe for lysosomal pathways of intracellular protein degradation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=130031

Cloning the mouse homolog of the human cystic fibrosis transmembrane conductance regulator gene.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=130031

ER quality control: the cytoplasmic connection

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=130031

Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=130031

P-glycoprotein. Associations between domains and between domains and molecular chaperones

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=130031

Genomic DNA sequence of Rhesus (M. mulatta) cystic fibrosis (CFTR) gene

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=130031

Cotranslational ubiquitination of cystic fibrosis transmembrane conductance regulator in vitro

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=130031

Effect of deletion mutations on the function of CFTR chloride channels

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=130031

A cross-species analysis of the cystic fibrosis transmembrane conductance regulator. Potential functional domains and regulatory sites

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=130031

Biosynthesis and degradation of CFTR.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=130031

Characterization of 19 disease-associated missense mutations in the regulatory domain of the cystic fibrosis transmembrane conductance regulator

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=130031

Disease-Associated Mutations in Cytoplasmic Loops 1 and 2 of Cystic Fibrosis Transmembrane Conductance Regulator Impede Processing or Opening of the Channel†

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=130031

Functional consequences of phenylalanine mutations in the predicted transmembrane domain of P-glycoprotein.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=130031

Multiple proteolytic systems, including the proteasome, contribute to CFTR processing

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=130031

The human multidrug resistance P-glycoprotein is inactive when its maturation is inhibited: potential for a role in cancer chemotherapy

28 November 2018

1 reference

12 December 2020

Functional characterization of the CFTR R domain using CFTR/MDR1 hybrid and deletion constructs

1 reference

12 December 2020

In vitro study of proteolytic degradation of rat histidine decarboxylase

1 reference

12 December 2020

Detection of a surface-exposed PEST like sequence in the metabotropic glutamate receptor mGluR1 alpha

1 reference

12 December 2020

Monoclonal antibodies to the Ca2+ + Mg2+-dependent ATPase of sarcoplasmic reticulum identify polymorphic forms of the enzyme and indicate the presence in the enzyme of a classical high-affinity Ca2+ binding site

1 reference

12 December 2020

Effect of Deleting the R Domain on CFTR-Generated Chloride Channels

1 reference

12 December 2020

Correction of Defective Protein Kinesis of Human P-glycoprotein Mutants by Substrates and Modulators

1 reference

12 December 2020

Evidence that endoplasmic reticulum (ER)-associated degradation of cystic fibrosis transmembrane conductance regulator is linked to retrograde translocation from the ER membrane

1 reference

12 December 2020

Removal of multiple arginine-framed trafficking signals overcomes misprocessing of delta F508 CFTR present in most patients with cystic fibrosis

1 reference

12 December 2020

Chaperoning the maturation of the cystic fibrosis transmembrane conductance regulator

1 reference

12 December 2020

Identifiers

DOI

10.1186/1471-2091-3-29

1 reference

Dimensions Publication ID

5 July 2017

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/1471-2091-3-29

PMC publication ID

130031

1 reference

5 July 2017

1 reference