Th2 cytokines and asthma. The role of interleukin-5 in allergic eosinophilic disease (Q24791847)

2

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F M Cuss

3

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R W Chapman

4

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R W Egan

Interleukin 5 synthesis by eosinophils: association with granules and immunoglobulin-dependent secretion

5

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language of work or name

English

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publication date

2001

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8 March 2001

5 references

3 August 2019

9 August 2019

12 October 2019

18 October 2019

20 November 2019

5 references

3 August 2019

9 August 2019

12 October 2019

18 October 2019

20 November 2019

2

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issue

2

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page(s)

71-9

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cites work

1 reference

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Cloning of cDNA for human T-cell replacing factor (interleukin-5) and comparison with the murine homologue

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Molecular cloning and expression of the human interleukin 5 receptor

7 April 2017

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A novel dimer configuration revealed by the crystal structure at 2.4 A resolution of human interleukin-5

7 April 2017

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Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

7 April 2017

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A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific α chain and a β chain shared with the receptor for GM-CSF

7 April 2017

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Autocrine interaction between IL-5 and IL-1beta mediates altered responsiveness of atopic asthmatic sensitized airway smooth muscle

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Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines

7 April 2017

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Molecular organization of the cytokine gene cluster, involving the human IL-3, IL-4, IL-5, and GM-CSF genes, on human chromosome 5

7 April 2017

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TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties

7 April 2017

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Structural design and molecular evolution of a cytokine receptor superfamily

7 April 2017

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Effect of Sch 55700, a humanized monoclonal antibody to human interleukin-5, on eosinophilic responses and bronchial hyperreactivity

7 April 2017

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Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model

28 September 2017

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Mechanisms of eosinophil recruitment

28 September 2017

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Signaling by the cytokine receptor superfamily: JAKs and STATs.

28 September 2017

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Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis

28 September 2017

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Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs.

28 September 2017

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The eosinophilic leukocyte: structure and function

28 September 2017

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Neutrophils and host defense

28 September 2017

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Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II.

28 September 2017

1 reference

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Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma. Relationship to bronchial hyperreactivity.

28 September 2017

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28 September 2017

Asthma and inflammation

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Messenger RNA expression of the cytokine gene cluster, interleukin 3 (IL-3), IL-4, IL-5, and granulocyte/macrophage colony-stimulating factor, in allergen-induced late-phase cutaneous reactions in atopic subjects

28 September 2017

1 reference

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Characterization of the mouse granulocyte-macrophage colony-stimulating factor (GM-CSF) gene promoter: nuclear factors that interact with an element shared by three lymphokine genes--those for GM-CSF, interleukin-4 (IL-4), and IL-5.

28 September 2017

1 reference

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Molecular Events Mediating T Cell Activation

28 September 2017

1 reference

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The Molecular Biology of Eosinophil Granule Proteins

28 September 2017

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Interleukin-5 modulates eosinophil accumulation in allergic guinea pig lung

28 September 2017

1 reference

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G-protein-regulated phospholipases C, D and A2-mediated signalling in neutrophils

28 September 2017

1 reference

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Regulation of human eosinophil production and function by interleukin-5

28 September 2017

1 reference

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Eosinophils express interleukin 5 and granulocyte macrophage-colony-stimulating factor mRNA at sites of allergic inflammation in asthmatics

28 September 2017

1 reference

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Delineation of IL-5 domains predicted to engage the IL-5 receptor complex

28 September 2017

1 reference

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Attenuation of allergic airway inflammation in IL-4 deficient mice.

28 September 2017

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Role of interleukin-5 in enhanced migration of eosinophils from airways of immunized guinea-pigs

30 May 2018

1 reference

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Phenotype of cells expressing mRNA for TH2-type (interleukin 4 and interleukin 5) and TH1-type (interleukin 2 and interferon gamma) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatic and normal control subjects.

30 May 2018

1 reference

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Early and late-phase bronchoconstriction after allergen challenge of nonanesthetized guinea pigs. I. The association of disordered airway physiology to leukocyte infiltration

30 May 2018

1 reference

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Exclusive leukotriene C4 synthesis by purified human eosinophils induced by opsonized zymosan

30 May 2018

1 reference

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IgA-induced eosinophil degranulation

30 May 2018

1 reference

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Characterization of interleukin 5 receptors on eosinophilic sublines from human promyelocytic leukemia (HL-60) cells

30 May 2018

1 reference

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Role of carbohydrate moiety of IL-5. Effect of tunicamycin on the glycosylation of IL-5 and the biologic activity of deglycosylated IL-5.

30 May 2018

1 reference

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Structural comparison of murine T-cell (B151K12)-derived T-cell-replacing factor (IL-5) with rIL-5: dimer formation is essential for the expression of biological activity.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=59571

Activation of phospholipase D in normodense human eosinophils

30 May 2018

1 reference

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Glucocorticoids inhibit cytokine-mediated eosinophil survival.

30 May 2018

1 reference

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Mutated interleukin-5 monomers are biologically inactive

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=59571

Role of the C-terminus in the biological activity of human interleukin 5

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=59571

Enhancement of human basophil histamine release by interleukin 5

30 May 2018

1 reference

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The effect of recombinant human interleukin-5 on eosinophil accumulation and degranulation in human nasal mucosa

30 May 2018

1 reference

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Antigen-induced acute and late-phase responses in primates

30 May 2018

1 reference

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Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response.

30 May 2018

1 reference

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Interleukin-5 mRNA in mucosal bronchial biopsies from asthmatic subjects

19 June 2018

1 reference

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Pharmacokinetics and pharmacodynamics of SB-240563, a humanized monoclonal antibody directed to human interleukin-5, in monkeys.

19 June 2018

1 reference

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Effects of cyclosporin A and dinactin on T-cell proliferation, interleukin-5 production, and murine pulmonary inflammation.

28 November 2018

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IL-5-deficient mice have a developmental defect in CD5+ B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses.

28 November 2018

1 reference

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T cells are necessary for Th2 cytokine production and eosinophil accumulation in airways of antigen-challenged allergic mice.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=59571

Inhibitory effect of the TRFK-5 anti-IL-5 antibody in a guinea pig model of asthma

28 November 2018

1 reference

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Cytotoxic effects of the guinea pig eosinophil major basic protein on tracheal epithelium

28 November 2018

1 reference

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Inhibition of antigen-induced airway hyperresponsiveness, but not acute hypoxia nor airway eosinophilia, by an antagonist of platelet-activating factor.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=59571

Effects of an antibody to interleukin-5 in a monkey model of asthma

28 November 2018

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12 December 2020

Involvement of IL-5 in a murine model of allergic pulmonary inflammation: prophylactic and therapeutic effect of an anti-IL-5 antibody

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12 December 2020

Characterization of the human IL-5 receptors on eosinophils

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12 December 2020

Immediate and Late Airway Response of Allergic Rhinitis Patients to Segmental Antigen Challenge: Characterization of Eosinophil and Mast Cell Mediators

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12 December 2020

Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma

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12 December 2020

Regulation of human eosinophil precursor production by cytokines: a comparison of recombinant human interleukin-1 (rhIL-1), rhIL-3, rhIL-5, rhIL-6, and rh granulocyte-macrophage colony-stimulating factor

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12 December 2020

Structure of recombinant human interleukin 5 produced by Chinese hamster ovary cells

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12 December 2020

Inflammatory cells and eosinophilic activity in asthmatics investigated by bronchoalveolar lavage. The effects of antiasthmatic treatment with budesonide or terbutaline

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12 December 2020

Allergen-induced asthmatic responses. Relationship between increases in airway responsiveness and increases in circulating eosinophils, basophils, and their progenitors

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12 December 2020

Activation of CD4+ T cells, increased TH2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma

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12 December 2020

Relationships among numbers of bronchoalveolar lavage cells expressing messenger ribonucleic acid for cytokines, asthma symptoms, and airway methacholine responsiveness in atopic asthma

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12 December 2020

Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects. The mast cell as a source of IL-4, IL-5, and IL-6 in human allergic mucosal inflammation

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12 December 2020

Analysis of cytokine transcripts in the bronchoalveolar lavage cells of patients with asthma

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12 December 2020

sVCAM-1 levels after segmental antigen challenge correlate with eosinophil influx, IL-4 and IL-5 production, and the late phase response

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12 December 2020

Cytokine receptors and signal transduction

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12 December 2020

Release of granule proteins from eosinophils cultured with IL-5

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12 December 2020

Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage

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12 December 2020

Analysis of the survival of mature human eosinophils: interleukin-5 prevents apoptosis in mature human eosinophils

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12 December 2020

Modulation of eosinophil chemotaxis by interleukin-5

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12 December 2020

Increases in activated T lymphocytes, eosinophils, and cytokine mRNA expression for interleukin-5 and granulocyte/macrophage colony-stimulating factor in bronchial biopsies after allergen inhalation challenge in atopic asthmatics

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12 December 2020

Inhibition of interleukin-5 gene expression by dexamethasone

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12 December 2020

CD4 T-lymphocyte activation in asthma is accompanied by increased serum concentrations of interleukin-5. Effect of glucocorticoid therapy

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12 December 2020

IL-5 is the predominant eosinophil-active cytokine in the antigen-induced pulmonary late-phase reaction

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12 December 2020

Effects of interleukin 5-induced pulmonary eosinophilia on airway reactivity in the guinea pig

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12 December 2020

Interleukin-5 mRNA stability in human T cells is regulated differently than interleukin-2, interleukin-3, interleukin-4, granulocyte/macrophage colony-stimulating factor, and interferon-gamma

1 reference

12 December 2020

Mapping and characterization of the epitope(s) of Sch 55700, a humanized mAb, that inhibits human IL-5

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12 December 2020

The Effect of IL-5 and Eotaxin Expression in the Lung on Eosinophil Trafficking and Degranulation and the Induction of Bronchial Hyperreactivity

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12 December 2020

Integrated signals between IL-13, IL-4, and IL-5 regulate airways hyperreactivity

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12 December 2020

Bronchoalveolar eosinophilia during allergen-induced late asthmatic reactions

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12 December 2020

Eosinophils, bronchial hyperreactivity and late-phase asthmatic reactions

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12 December 2020

Respiratory burst of normal human eosinophils

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12 December 2020

Eosinophils do respond to fMLP

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12 December 2020

Recombinant human interleukin 5 is an eosinophil differentiation factor but has no activity in standard human B cell growth factor assays

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12 December 2020

Human interleukin-5 (IL-5) regulates the production of eosinophils in human bone marrow cultures: comparison and interaction with IL-1, IL-3, IL-6, and GMCSF

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12 December 2020

T cells are the principal source of interleukin-5 mRNA in allergen-induced rhinitis

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12 December 2020

Eosinophil survival activity identified as interleukin-5 is associated with eosinophil recruitment and degranulation and lung injury twenty-four hours after segmental antigen lung challenge

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12 December 2020

The influence of IL-3, IL-5, and GM-CSF on normal human eosinophil and neutrophil C3b-induced degranulation

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12 December 2020

Interleukin-5 Preferentially Recruits Eosinophils from Vessels in Nasal Mucosa

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12 December 2020

Clinical significance of measuring levels of sputum and serum ECP and serum IL-5 in bronchial asthma

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12 December 2020

TCR-dependent and -independent signaling mechanisms differentially regulate lymphokine gene expression in the murine T helper clone D10.G4.1.

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12 December 2020

The regulation of interleukin 5 and interleukin 3 gene expression in human T cells

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12 December 2020

Eosinophil granule proteins increase microvascular macromolecular transport in the hamster cheek pouch

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12 December 2020

Detection of interleukin-5 messenger RNA and interleukin-5 protein in bronchial biopsies from asthma by nonradioactive in situ hybridization and immunohistochemistry

1 reference

12 December 2020

Characterization of a murine model of allergic pulmonary inflammation

1 reference

12 December 2020

Activated T cells and cytokines in bronchoalveolar lavages from patients with various lung diseases associated with eosinophilia

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12 December 2020

Interleukin-5 Messenger RNA and Immunoreactive Protein Expression by Activated Eosinophils in Lesional Atopic Dermatitis Skin

1 reference

12 December 2020

Allergen-induced changes in bone marrow progenitors and airway responsiveness in dogs and the effect of inhaled budesonide on these parameters

1 reference

12 December 2020

Mechanisms of allergic pulmonary eosinophilia in the mouse

1 reference

12 December 2020

Pretreatment with an antibody to interleukin-5 prevents loss of pulmonary M2 muscarinic receptor function in antigen-challenged guinea pigs

1 reference

12 December 2020

Mast cells modulate allergic pulmonary eosinophilia in mice

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12 December 2020

Identifiers

DOI

10.1186/RR41

1 reference

Dimensions Publication ID

2452842

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/rr41

2452842

1 reference

1 reference

1 reference