Resistance to gemcitabine in a human follicular lymphoma cell line is due to partial deletion of the deoxycytidine kinase gene (Q24794747)

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28 December 2019

title

Resistance to gemcitabine in a human follicular lymphoma cell line is due to partial deletion of the deoxycytidine kinase gene (English)

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28 December 2019

1 reference

3

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28 December 2019

John R. Mackey

6

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28 December 2019

Charles Dumontet

7

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28 December 2019

author name string

Carlos María Galmarini

1

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28 December 2019

Marilyn L Clarke

2

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28 December 2019

Cheryl L Santos

4

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28 December 2019

Emeline Cros

5

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28 December 2019

language of work or name

English

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publication date

24 May 2004

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28 December 2019

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28 December 2019

volume

4

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28 December 2019

issue

1

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page(s)

8

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Bim: a novel member of the Bcl-2 family that promotes apoptosis

28 December 2019

cites work

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Differential transport of cytosine-containing nucleosides by recombinant human concentrative nucleoside transporter protein hCNT1

7 April 2017

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Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2',2'-difluorodeoxycytidine

7 April 2017

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Cytosolic and mitochondrial deoxyribonucleotidases: activity with substrate analogs, inhibitors and implications for therapy

7 April 2017

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Drug resistance to cytotoxic nucleoside analogues

28 September 2017

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Nucleoside analogues and nucleobases in cancer treatment.

28 September 2017

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Determinants of resistance to 2',2'-difluorodeoxycytidine (gemcitabine).

28 September 2017

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Expression of a non-functional p53 affects the sensitivity of cancer cells to gemcitabine.

28 September 2017

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Tumor uptake and elimination of 2',2'-difluoro-2'-deoxycytidine (gemcitabine) after deoxycytidine kinase gene transfer: correlation with in vivo tumor response.

28 September 2017

1 reference

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Mechanisms of uptake and resistance to troxacitabine, a novel deoxycytidine nucleoside analogue, in human leukemic and solid tumor cell lines.

28 September 2017

1 reference

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Nucleoside analogues: mechanisms of drug resistance and reversal strategies.

28 September 2017

1 reference

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Activation of deoxycytidine kinase by inhibition of DNA synthesis in human lymphocytes.

28 September 2017

1 reference

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Cross-resistance in the 2',2'-difluorodeoxycytidine (gemcitabine)-resistant human ovarian cancer cell line AG6000 to standard and investigational drugs

28 September 2017

1 reference

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Treatment of normal and malignant cells with nucleoside analogues and etoposide enhances deoxycytidine kinase activity

28 September 2017

1 reference

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Overexpression of ribonucleotide reductase as a mechanism of resistance to 2,2-difluorodeoxycytidine in the human KB cancer cell line

28 September 2017

1 reference

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Prodrugs of Ara-CMP and Ara-AMP with a S-acyl-2-thioethyl (SATE) biolabile phosphate protecting group: synthesis and biological evaluation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=428575

Decreased resistance to gemcitabine (2',2'-difluorodeoxycitidine) of cytosine arabinoside-resistant myeloblastic murine and rat leukemia cell lines: role of altered activity and substrate specificity of deoxycytidine kinase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=428575

Lack of cross-resistance with gemcitabine and cytarabine in cladribine-resistant HL60 cells with elevated 5'-nucleotidase activity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=428575

Cross-resistance of the gemcitabine resistant human ovarian cancer cell line AG6000 to standard and investigational drugs.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=428575

Molecular identification of the equilibrative NBMPR-sensitive (es) nucleoside transporter and demonstration of an equilibrative NBMPR-insensitive (ei) transport activity in human erythroleukemia (K562) cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=428575

Forced expression of cytidine deaminase confers resistance to cytosine arabinoside and gemcitabine

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=428575

Preclinical characteristics of gemcitabine.

28 September 2017

1 reference

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Bcl-2 and the regulation of programmed cell death

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=428575

Gemcitabine: metabolism, mechanisms of action, and self-potentiation.

28 September 2017

1 reference

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Development and molecular characterization of a 2',2'-difluorodeoxycytidine-resistant variant of the human ovarian carcinoma cell line A2780.

28 September 2017

1 reference

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Activation of deoxycytidine kinase by gamma-irradiation and inactivation by hyperosmotic shock in human lymphocytes

28 September 2017

1 reference

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Growth inhibition of human lymphoma cell lines by the marine products, dolastatins 10 and 15.

30 May 2018

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2',2'-Difluoro-deoxycytidine (gemcitabine) incorporation into RNA and DNA of tumour cell lines

30 May 2018

1 reference

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Resistance to 1-beta-D-arabinofuranosylcytosine in human T-lymphoblasts mediated by mutations within the deoxycytidine kinase gene

30 May 2018

1 reference

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A non-organic and non-enzymatic extraction method gives higher yields of genomic DNA from whole-blood samples than do nine other methods tested

30 May 2018

1 reference

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Sensitization of ara-C-resistant lymphoma cells by a pronucleotide analogue.

30 May 2018

1 reference

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Deletion mutants of human deoxycytidine kinase mRNA in cells resistant to antitumor cytosine nucleosides

28 November 2018

1 reference

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High incidence of alternatively spliced forms of deoxycytidine kinase in patients with resistant acute myeloid leukemia.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=428575

Common resistance mechanisms to deoxynucleoside analogues in variants of the human erythroleukaemic line K562.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=428575

Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=428575

Synthesis and study of a new series of phosphoramidate derivatives as mononucleotide prodrugs

28 November 2018

1 reference

12 December 2020

The role of deoxycytidine kinase in gemcitabine cytotoxicity

1 reference

12 December 2020

Separation of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate and 9-beta-D-arabinofuranosyl-2-fluoroadenine 5'-triphosphate in human leukemia cells by high-performance liquid chromatography

1 reference

12 December 2020

2'-Deoxy-2'-methylenecytidine and 2'-deoxy-2',2'-difluorocytidine 5'-diphosphates: potent mechanism-based inhibitors of ribonucleotide reductase

1 reference

12 December 2020

Action of 2',2'-difluorodeoxycytidine on DNA synthesis

1 reference

12 December 2020

Kinetic studies on 2',2'-difluorodeoxycytidine (Gemcitabine) with purified human deoxycytidine kinase and cytidine deaminase

1 reference

12 December 2020

Gemcitabine: a modulator of intracellular nucleotide and deoxynucleotide metabolism

1 reference

12 December 2020

Ribonucleotide reductases: radical enzymes with suicidal tendencies

1 reference

12 December 2020

Bcl-2 overexpression is associated with resistance to paclitaxel, but not gemcitabine, in multiple myeloma cells.

1 reference

12 December 2020

Activation of deoxycytidine kinase during inhibition of DNA synthesis by 2-chloro-2'-deoxyadenosine (Cladribine) in human lymphocytes

1 reference

12 December 2020

Identifiers

DOI

10.1186/1471-2210-4-8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15157282%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

28 December 2019

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/1471-2210-4-8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15157282%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

PubMed publication ID

15157282

1 reference