Integrated allosteric regulation in the S. cerevisiae carbamylphosphate synthetase - aspartate transcarbamylase multifunctional protein (Q24795316)

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Bernadette Penverne

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Jean-Luc Souciet

3

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Serge Potier

4

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Hedeel Guy

5

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David Evans

6

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Patrick Vicart

7

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Guy Hervé

Protein measurement with the Folin phenol reagent

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language of work or name

English

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publication date

5 May 2004

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published in

BMC Biochemistry

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volume

5

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issue

1

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page(s)

6

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cites work

1 reference

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The binding of inosine monophosphate to Escherichia coli carbamoyl phosphate synthetase

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The structure of carbamoyl phosphate synthetase determined to 2.1 A resolution

7 April 2017

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Complex of N-phosphonacetyl-L-aspartate with aspartate carbamoyltransferase. X-ray refinement, analysis of conformational changes and catalytic and allosteric mechanisms

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SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

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A general method applicable to the search for similarities in the amino acid sequence of two proteins

7 April 2017

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The N-acetylglutamate synthase/N-acetylglutamate kinase metabolon of Saccharomyces cerevisiae allows co-ordinated feedback regulation of the first two steps in arginine biosynthesis

7 April 2017

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Half of Saccharomyces cerevisiae carbamoyl phosphate synthetase produces and channels carbamoyl phosphate to the fused aspartate transcarbamoylase domain

7 April 2017

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Yeast carbamyl phosphate synthetase. Structure of the yeast gene and homology to Escherichia coli carbamyl phosphate synthetase

7 April 2017

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The aspartate transcarbamylase and carbamoyl phosphate synthetase of yeast: A multi-functional enzyme complex

7 April 2017

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Evidence for an Activated Form of Carbon Dioxide in the Reaction Catalyzed by Escherichia coli Carbamyl Phosphate Synthetase*

7 April 2017

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Aggregation states and catalytic properties of the multienzyme complex catalyzing the initial steps of pyrimidine biosynthesis in rat liver

7 April 2017

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Pressure-induced dissociation of carbamoyl-phosphate synthetase domains. The catalytically active form is dimeric

7 April 2017

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The carbamoyl phosphate synthetase-aspartate transcarbamoylase complex of Saccharomyces cerevisiae: molecular and cellular aspects

28 September 2017

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Proteolytically induced changes in the molecular form of the carbamyl phosphate synthetase-uracil-aspartate transcarbamylase complex coded for by the URA2 locus in Saccharomyces cerevisiae.

28 September 2017

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The carB gene of Escherichia coli: a duplicated gene coding for the large subunit of carbamoyl-phosphate synthetase

28 September 2017

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The gene coding for carbamoyl-phosphate synthetase I was formed by fusion of an ancestral glutaminase gene and a synthetase gene

28 September 2017

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Escherichia coli carbamoyl-phosphate synthetase: domains of glutaminase and synthetase subunit interaction

28 September 2017

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Mechanism and regulation of the glutamine-dependent carbamyl phosphate synthetase of Escherichia coli

28 September 2017

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In the presence of CTP, UTP becomes an allosteric inhibitor of aspartate transcarbamoylase

28 September 2017

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Kinetics and Reaction Mechanism of the Carbamylphosphate Synthetase of a Multienzyme Aggregate from Yeast

28 September 2017

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Purification from hamster cells of the multifunctional protein that initiates de novo synthesis of pyrimidine nucleotides

28 September 2017

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Conversion of carbamoyl phosphate to hydroxyurea. An assay for carbamoylphosphate synthetase.

28 September 2017

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The rudimentary gene of Drosophila melanogaster encodes four enzymic functions

30 May 2018

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Organization of the yeast URA2 gene: identification of a defective dihydroorotase-like domain in the multifunctional carbamoylphosphate synthetase-aspartate transcarbamylase complex

30 May 2018

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The primary structure of the aspartate transcarbamylase region of the URA2 gene product in Saccharomyces cerevisiae. Features involved in activity and nuclear localization

30 May 2018

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Domain structure of the large subunit of Escherichia coli carbamoyl phosphate synthetase. Location of the binding site for the allosteric inhibitor UMP in the COOH-terminal domain.

30 May 2018

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Quantifying the allosteric properties of Escherichia coli carbamyl phosphate synthetase: determination of thermodynamic linked-function parameters in an ordered kinetic mechanism

30 May 2018

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Allosteric regulation and substrate channeling in multifunctional pyrimidine biosynthetic complexes: analysis of isolated domains and yeast-mammalian chimeric proteins

30 May 2018

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Structural modeling and electrostatic properties of aspartate transcarbamylase from Saccharomyces cerevisiae.

28 November 2018

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Superproduction and rapid purification of Escherichia coli aspartate transcarbamylase and its catalytic subunit under extreme derepression of the pyrimidine pathway.

28 November 2018

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Genetic analysis of yeast strains lacking negative feedback control: a one-step method for positive selection and cloning of carbamoylphosphate synthetase-aspartate transcarbamoylase mutants unable to respond to UTP

28 November 2018

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Uridylic acid synthesis in Ehrlich ascites carcinoma. Properties, subcellular distribution, and nature of enzyme complexes of the six biosynthetic enzymes

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In situ behavior of the pyrimidine pathway enzymes in Saccharomyces cerevisiae. I. Catalytic and regulatory properties of aspartate transcarbamylase

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Molecular characterization of a Dictyostelium discoideum gene encoding a multifunctional enzyme of the pyrimidine pathway

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Identification of the regulatory domain of the mammalian multifunctional protein CAD by the construction of an Escherichia coli hamster hybrid carbamyl-phosphate synthetase

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Homology and mutagenesis studies of hamster dihydroorotase

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Function of the major synthetase subdomains of carbamyl-phosphate synthetase

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Serine 948 and threonine 1042 are crucial residues for allosteric regulation of Escherichia coli carbamoylphosphate synthetase and illustrate coupling effects of activation and inhibition pathways

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A study of the aspartate transcarbamylase activity of yeast

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In situ behavior of the pyrimidine pathway enzymes in Saccharomyces cerevisiae. 4. The channeling of carbamylphosphate to aspartate transcarbamylase and its partition in the pyrimidine and arginine pathways

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