Drugs in development: bisphosphonates and metalloproteinase inhibitors (Q24795847)

28 December 2023

author name string

Jon B. Catterall

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12716443

28 December 2023

Tim E. Cawston

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12716443

full work available at URL

28 December 2023

language of work or name

English

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publication date

2003

0 references

8 November 2002

5 references

13 March 2019

17 June 2019

28 September 2019

2 October 2019

12 November 2019

https://arthritis-research.biomedcentral.com/track/pdf/10.1186/ar604

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12716443

https://europepmc.org/articles/PMC154424

28 December 2023

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12716443

https://europepmc.org/articles/PMC154424?pdf=render

28 December 2023

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12716443

Arthritis Research and Therapy

28 December 2023

published in

5 references

13 March 2019

17 June 2019

28 September 2019

2 October 2019

12 November 2019

5

0 references

issue

1

0 references

page(s)

12-24

0 references

cites work

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Clinical trials of a stromelysin inhibitor. Osteoarthritis, matrix metalloproteinase inhibition, cartilage loss, surrogate markers, and clinical implications

28 September 2017

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28 September 2017

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Residue 2 of TIMP-1 is a major determinant of affinity and specificity for matrix metalloproteinases but effects of substitutions do not correlate with those of the corresponding P1' residue of substrate

28 September 2017

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Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage

28 September 2017

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28 September 2017

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28 September 2017

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Randomized phase II trial comparing different doses of the bisphosphonate ibandronate in the treatment of hypercalcemia of malignancy

28 September 2017

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Synovial tissue macrophages and joint erosion in rheumatoid arthritis

28 September 2017

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28 September 2017

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Treatment of destructive arthritic disorders with MMP inhibitors. Potential role of tetracyclines

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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What holds us together? Why do some of us fall apart? What can we do about it?

30 May 2018

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Tiludronate inhibits protein tyrosine phosphatase activity in osteoclasts.

30 May 2018

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A possible mechanism of the specific action of bisphosphonates on osteoclasts: tiludronate preferentially affects polarized osteoclasts having ruffled borders

30 May 2018

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30 May 2018

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Effect of ethane-1-hydroxy-1,1-diphosphonate (EHDP) and dichloromethylene diphosphonate (Cl 2 MDP) on the calcification and resorption of cartilage and bone in the tibial epiphysis and metaphysis of rats

30 May 2018

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The binding of pyrophosphate and two diphosphonates by hydroxyapatite crystals

30 May 2018

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30 May 2018

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30 May 2018

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30 May 2018

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Effects of 4-amino-1-hydroxybutylidene bisphosphonate on bone biomechanics in rats.

30 May 2018

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Prevention of leaflet calcification of bioprosthetic heart valves with diphosphonate injection therapy. Experimental studies of optimal dosages and therapeutic durations.

30 May 2018

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30 May 2018

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28 November 2018

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28 November 2018

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28 November 2018

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Combined analysis of studies of the effects of the matrix metalloproteinase inhibitor marimastat on serum tumor markers in advanced cancer: selection of a biologically active and tolerable dose for longer-term studies.

28 November 2018

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Human cathepsin K cleaves native type I and II collagens at the N-terminal end of the triple helix

28 November 2018

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28 November 2018

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28 November 2018

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Kinetic studies of bone and mineral metabolism during treatment with (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate (APD) in rats

28 November 2018

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Effects of bisphosphonates on isolated rat osteoclasts as examined by reflected light microscopy

28 November 2018

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Ro 32-3555, an orally active collagenase selective inhibitor, prevents structural damage in the STR/ORT mouse model of osteoarthritis

28 November 2018

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12 December 2020

TNF-alpha converting enzyme (TACE) is inhibited by TIMP-3

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12 December 2020

The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway

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12 December 2020

Production of tissue inhibitor of metalloproteinases 3 is selectively enhanced by calcium pentosan polysulfate in human rheumatoid synovial fibroblasts

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12 December 2020

Differential expression pattern of membrane-type matrix metalloproteinases in rheumatoid arthritis

1 reference

12 December 2020

Effects of bisphosphonate on matrix metalloproteinase enzymes in human periodontal ligament cells

1 reference

12 December 2020

Synovial macrophage depletion with clodronate-containing liposomes in rheumatoid arthritis

1 reference

12 December 2020

Comparison of cathepsins K and S expression within the rheumatoid and osteoarthritic synovium

1 reference

12 December 2020

The influence of pyrophosphate analogues (diphosphonates) on the precipitation and dissolution

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12 December 2020

Diphosphonates inhibit hydroxyapatite dissolution in vitro and bone resorption in tissue culture and in vivo

1 reference

12 December 2020

Effect of diphosphonate on human supragingival calculus

1 reference

12 December 2020

The influence of pyrophosphate, condensed phosphates, phosphonates and other phosphate compounds on the dissolution of hydroxyapatite in vitro and on bone resorption induced by parathyroid hormone in tissue culture and in thyroparathyroidectomised r

1 reference

12 December 2020

Reduction of Dental Calculus in Humans Through the Use of a Dentifrice Containing a Crystal-Growth Inhibitor

1 reference

12 December 2020

The effects of diphosphonates, polyphosphates, and calcitonin on "immobilisation osteoporosis" in rats

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12 December 2020

The effects of various diphosphonates on a rat model of cardiac calciphylaxis

1 reference

12 December 2020

Effect of dichloromethane diphosphonate on cortisol-induced bone loss in young adult rabbits

1 reference

12 December 2020

Efficacy of amino-hydroxypropylidene bisphosphonate in hypercalcemia: observations on regulation of serum calcium

1 reference

12 December 2020

Results of the administration of diphosphonate for the prevention of heterotopic ossification after total hip arthroplasty

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12 December 2020

The effects of dichloromethylene biphosphonate on osteoporotic femora of adult castrate male rats

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12 December 2020

Structural requirements for bisphosphonate actions in vitro

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12 December 2020

Pamidronate: an unrecognized problem in gastrointestinal tolerability

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12 December 2020

Effects of the bisphosphonate YM175 on bone mineral density, strength, structure, and turnover in ovariectomized beagles on concomitant dietary calcium restriction

1 reference

12 December 2020

Long-term amelioration of rat adjuvant arthritis following systemic elimination of macrophages by clodronate-containing liposomes

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12 December 2020

New collagenolytic enzymes/cascade identified at the pannus-hard tissue junction in rheumatoid arthritis: destruction from above

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12 December 2020

Prevention of steroid-induced osteoporosis with (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate (APD)

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12 December 2020

Application of an in vitro model and a clinical protocol in the assessment of the potency of a new bisphosphonate

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12 December 2020

Effects of the bisphosphonate tiludronate on bone resorption, calcium balance, and bone mineral density

1 reference

12 December 2020

Continuous therapy with pamidronate, a potent bisphosphonate, in postmenopausal osteoporosis

1 reference

12 December 2020

Comparison of new biochemical markers of bone turnover in late postmenopausal osteoporotic women in response to alendronate treatment

1 reference

12 December 2020

The effect of free and liposome-encapsulated clodronate on the hepatic mononuclear phagocyte system in the rat

1 reference

12 December 2020

Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo

1 reference

12 December 2020

Synovial tissue macrophage populations and articular damage in rheumatoid arthritis

1 reference

12 December 2020

Wanted--the collagenase responsible for the destruction of the collagen network in human cartilage!

1 reference

12 December 2020

Cyclical intravenous clodronate in postmenopausal osteoporosis: results of a long-term clinical trial

1 reference

12 December 2020

Bisphosphonates induce apoptosis in mouse macrophage-like cells in vitro by a nitric oxide-independent mechanism

1 reference

12 December 2020

The bisphosphonate tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase

1 reference

12 December 2020

Efficacy of pamidronate in reducing skeletal complications in patients with breast cancer and lytic bone metastases. Protocol 19 Aredia Breast Cancer Study Group

1 reference

12 December 2020

Matrix metalloproteinase 13 (collagenase 3) in human rheumatoid synovium

1 reference

12 December 2020

Human neutrophil collagenase MMP-8 in peri-implant sulcus fluid and its inhibition by clodronate

1 reference

12 December 2020

Alendronate inhibition of protein-tyrosine-phosphatase-meg1

1 reference

12 December 2020

Comparative immunolocalization studies of collagenase 1 and collagenase 3 production in the rheumatoid lesion, and by human chondrocytes and synoviocytes in vitro

1 reference

12 December 2020

Bisphosphonates: mechanisms of action

1 reference

12 December 2020

Collagenase-1 and collagenase-3 synthesis in normal and early experimental osteoarthritic canine cartilage: an immunohistochemical study

1 reference

12 December 2020

MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover

1 reference

12 December 2020

Intermittent cyclical etidronate treatment of postmenopausal osteoporosis

1 reference

12 December 2020

Inhibition of bone mineral loss during lactation by Cl2MBP

1 reference

12 December 2020

Degradation of collagen in the bone-resorbing compartment underlying the osteoclast involves both cysteine-proteinases and matrix metalloproteinases

1 reference

12 December 2020

Metabolism of halogenated bisphosphonates by the cellular slime mould dictyostelium discoideum

1 reference

12 December 2020

Protective effects of disodium etidronate and pamidronate against the biomechanical repercussion of betamethasone-induced osteopenia in growing rat femurs

1 reference

12 December 2020

Reversible depletion of synovial lining cells after intra-articular treatment with liposome-encapsulated dichloromethylene diphosphonate

1 reference

12 December 2020

Lipophilic 1,1-bisphosphonates are potent squalene synthase inhibitors and orally active cholesterol lowering agents in vivo

1 reference

12 December 2020