Lefty blocks a subset of TGFbeta signals by antagonizing EGF-CFC coreceptors (Q24796038)

GOA release 2020-03-11

Activin receptor IIB

1 reference

GOA release 2020-03-11

author name string

Simon K Cheng

1

0 references

Felix Olale

2

0 references

Ali H Brivanlou

3

0 references

Alexander F Schier

Creative Commons Attribution 4.0 International

4

0 references

language of work or name

English

0 references

publication date

February 2004

0 references

published in

PLOS Biology

0 references

volume

2

0 references

issue

2

0 references

page(s)

E30

0 references

copyright license

start time

17 February 2004

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo

7 April 2017

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lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal

7 April 2017

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Left-right asymmetric expression of the TGF beta-family member lefty in mouse embryos

7 April 2017

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Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation

7 April 2017

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Characterization of type I receptors for transforming growth factor-beta and activin

7 April 2017

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A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse

7 April 2017

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Expression cloning of an activin receptor, a predicted transmembrane serine kinase

7 April 2017

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Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors

7 April 2017

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Structure of the zebrafish snail1 gene and its expression in wild-type, spadetail and no tail mutant embryos

7 April 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=340941

A transcriptional partner for MAD proteins in TGF-beta signalling

7 April 2017

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Nodal Signaling in Vertebrate Development

7 April 2017

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Decrypting the role of Cripto in tumorigenesis

28 September 2017

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Cripto forms a complex with activin and type II activin receptors and can block activin signaling

28 September 2017

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EGF-CFC proteins are essential coreceptors for the TGF-beta signals Vg1 and GDF1.

28 September 2017

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The zebrafish Nodal signal Squint functions as a morphogen

28 September 2017

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28 September 2017

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The EGF-CFC family: novel epidermal growth factor-related proteins in development and cancer.

28 September 2017

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Feedback control of intercellular signalling in development

28 September 2017

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Expression cloning of Xantivin, a Xenopus lefty/antivin-related gene, involved in the regulation of activin signaling during mesoderm induction

28 September 2017

1 reference

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The EGF-CFC gene family in vertebrate development.

28 September 2017

1 reference

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Nodal signalling in vertebrate development.

28 September 2017

1 reference

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Specificity, diversity, and regulation in TGF-beta superfamily signaling.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=340941

The Drosophila activin receptor baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=340941

Antivin, a novel and divergent member of the TGFbeta superfamily, negatively regulates mesoderm induction.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=340941

A differential display strategy identifies Cryptic, a novel EGF-related gene expressed in the axial and lateral mesoderm during mouse gastrulation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=340941

Patterning activities of vertebrate hedgehog proteins in the developing eye and brain.

28 September 2017

1 reference

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A novel retrovirally induced embryonic lethal mutation in the mouse: assessment of the developmental fate of embryonic stem cells homozygous for the 413.d proviral integration

28 September 2017

1 reference

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Transfection with a CRIPTO anti-sense plasmid suppresses endogenous CRIPTO expression and inhibits transformation in a human embryonal carcinoma cell line

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=340941

Identification of two amino acids in activin A that are important for biological activity and binding to the activin type II receptors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=340941

Zebrafish organizer development and germ-layer formation require nodal-related signals.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=340941

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=340941

Inhibition of CRIPTO expression and tumorigenicity in human colon cancer cells by antisense RNA and oligodeoxynucleotides.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=340941

Nodal induces ectopic goosecoid and lim1 expression and axis duplication in zebrafish.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=340941

Expression of zebrafish goosecoid and no tail gene products in wild-type and mutant no tail embryos

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=340941

Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=340941

Activin-like factor from a Xenopus laevis cell line responsible for mesoderm induction

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=340941

Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=340941

Expression of cripto, a novel gene of the epidermal growth factor gene family, leads to in vitro transformation of a normal mouse mammary epithelial cell line

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=340941

Embryonic expression and functional analysis of a Xenopus activin receptor

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=340941

Cloning of a Second Type of Activin Receptor and Functional Characterization in Xenopus Embryos

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=340941

The zebrafishnodal-related genesouthpawis required for visceral and diencephalic left-right asymmetry

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=340941

Lefty-dependent inhibition of Nodal- and Wnt-responsive organizer gene expression is essential for normal gastrulation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=340941

Lefty antagonism of Squint is essential for normal gastrulation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=340941

Lefty proteins are long-range inhibitors of squint-mediated nodal signaling.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=340941

Inhibition of Nodal signalling by Lefty mediated through interaction with common receptors and efficient diffusion

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=340941

Diffusion of nodal signaling activity in the absence of the feedback inhibitor Lefty2.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=340941

Simultaneous blockage of different EGF-like growth factors results in efficient growth inhibition of human colon carcinoma xenografts.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=340941

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=340941

Asymmetric expression of antivin/lefty1 in the early chick embryo.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=340941

A role of the cryptic gene in the correct establishment of the left-right axis.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=340941

Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=340941

Regulation of midline development by antagonism of lefty and nodal signaling.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=340941

Positional cloning identifies zebrafish one-eyed pinhead as a permissive EGF-related ligand required during gastrulation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=340941

A Xenopus type I activin receptor mediates mesodermal but not neural specification during embryogenesis.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=340941

The DVR-1 (Vg1) transcript of zebrafish is maternally supplied and distributed throughout the embryo.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=340941

Lithium perturbation and goosecoid expression identify a dorsal specification pathway in the pregastrula zebrafish.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=340941

The EGF-CFC protein one-eyed pinhead is essential for nodal signaling

28 November 2018

1 reference

12 December 2020

Activin- and Nodal-related factors control antero–posterior patterning of the zebrafish embryo

1 reference

12 December 2020

Morpholino knock-down of antivin1 and antivin2 upregulates nodal signaling

1 reference

12 December 2020

Regulation of gut and heart left-right asymmetry by context-dependent interactions between xenopus lefty and BMP4 signaling

1 reference

12 December 2020

A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos

1 reference

12 December 2020

Zebrafish nodal-related 2 encodes an early mesendodermal inducer signaling from the extraembryonic yolk syncytial layer

1 reference

12 December 2020

10.1371/JOURNAL.PBIO.0020030

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DOI

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release_tog5sqyebfeqjjhjrlsy6cqine

2415779

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24 November 2022

mapped directly with Wikidata item

2415779

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1 reference