Pharmacological disruption of insulin-like growth factor 1 binding to IGF-binding proteins restores anabolic responses in human osteoarthritic chondrocytes (Q24796505)

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English	Pharmacological disruption of insulin-like growth factor 1 binding to IGF-binding proteins restores anabolic responses in human osteoarthritic chondrocytes	scientific article

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Pharmacological disruption of insulin-like growth factor 1 binding to IGF-binding proteins restores anabolic responses in human osteoarthritic chondrocytes (English)

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author name string

Frédéric De Ceuninck

1

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Audrey Caliez

2

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Laurent Dassencourt

3

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Philippe Anract

4

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Pierre Renard

5

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publication date

2004

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Arthritis Research and Therapy

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6

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5

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R393-403

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Structure-function analysis of a phage display-derived peptide that binds to insulin-like growth factor binding protein 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=546277

7 April 2017

A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=546277

28 September 2017

Cartilage regeneration by gene therapy

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=546277

28 September 2017

Insulin-like growth factor binding protein proteolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=546277

28 September 2017

Structural biology of insulin and IGF1 receptors: implications for drug design

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=546277

28 September 2017

Identification of a nonpeptide ligand that releases bioactive insulin-like growth factor-I from its binding protein complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=546277

28 September 2017

Insulin-like growth factor binding protein (IGFBP) displacers: relevance to the treatment of renal disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=546277

28 September 2017

Molecular mimics of insulin-like growth factor 1 (IGF-1) for inhibiting IGF-1: IGF-binding protein interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=546277

28 September 2017

Displacement of insulin-like growth factors from their binding proteins as a potential treatment for stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=546277

28 September 2017

Chondrocytes from osteoarthritic cartilage have increased expression of insulin-like growth factor I (IGF-I) and IGF-binding protein-3 (IGFBP-3) and -5, but not IGF-II or IGFBP-4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=546277

28 September 2017

The roles of tyrosines 24, 31, and 60 in the high affinity binding of insulin-like growth factor-I to the type 1 insulin-like growth factor receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=546277

28 September 2017

Upregulation of insulin-like growth factor I gene expression in the lesions of osteoarthritic human articular cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=546277

28 September 2017

Regulation of insulin-like growth factor (IGF)-I action by matrix metalloproteinase-3 involves selective disruption of IGF-I/IGF-binding protein-3 complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=546277

30 May 2018

Discovery of a series of nonpeptide small molecules that inhibit the binding of insulin-like growth factor (IGF) to IGF-binding proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=546277

30 May 2018

Overexpression of human insulin-like growth factor-I promotes new tissue formation in an ex vivo model of articular chondrocyte transplantation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=546277

30 May 2018

IGF/IGFBP axis in cartilage and bone in osteoarthritis pathogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=546277

30 May 2018

Comparison of in vivo effects of insulin-like growth factors I and II and of growth hormone in hypophysectomized rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=546277

30 May 2018

Stimulation of proteoglycan biosynthesis by serum and insulin-like growth factor-I in cultured bovine articular cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=546277

30 May 2018

Insulin-like growth factors maintain steady-state metabolism of proteoglycans in bovine articular cartilage explants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=546277

30 May 2018

Production of insulin-like growth factors and their binding proteins by rabbit articular chondrocytes: relationships with cell multiplication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=546277

30 May 2018

Neuroprotective Effects of Insulin-Like Growth Factor-Binding Protein Ligand Inhibitors in Vitro and in Vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=546277

28 November 2018

Quinoline-carboxylic acids are potent inhibitors that inhibit the binding of insulin-like growth factor (IGF) to IGF-binding proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=546277

28 November 2018

6,7-dihydroxyisoquinoline-3-carboxylic acids are potent inhibitors on the binding of insulin-like growth factor (IGF) to IGF-binding proteins: optimization of the 1-position benzoyl side chain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=546277

28 November 2018

In silico and NMR identification of inhibitors of the IGF-I and IGF-binding protein-5 interaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=546277

28 November 2018

The insulin-like growth factor binding proteins in uncultured human cartilage: increases in insulin-like growth factor binding protein 3 during osteoarthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=546277

28 November 2018

Insulin-like growth factor-I enhances cell-based repair of articular cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=546277

28 November 2018

IGF and IGF-binding protein system in the synovial fluid of osteoarthritic and rheumatoid arthritic patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=546277

28 November 2018

Insulinlike growth factor-I gene therapy applications for cartilage repair.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=546277

28 November 2018

Production and hormonal regulation of insulin-like growth factor binding proteins in bovine chondrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=546277

28 November 2018

Synthesis of insulin-like growth factor binding protein 3 in vitro in human articular cartilage cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/15380039

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in the local regulation of insulin-like growth factors I and II and insulin-like growth factor-binding proteins in osteoarthritis of the canine stifle joint secondary to cruciate ligament rupture

1 reference

https://pubmed.ncbi.nlm.nih.gov/15380039

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signaling mechanisms leading to the regulation of differentiation and apoptosis of articular chondrocytes by insulin-like growth factor-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/15380039

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assays of proteoglycan and collagen degradation in cultures of rabbit cartilage explants

1 reference

https://pubmed.ncbi.nlm.nih.gov/15380039

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Local injections of human or rat growth hormone or of purified human somatomedin-C stimulate unilateral tibial epiphyseal growth in hypophysectomized rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15380039

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of serum insulin-like growth factor binding proteins using western blotting: use of the method for titration of the binding proteins and competitive binding studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/15380039

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of somatomedin-C/insulin-like growth factor I and growth hormone on cultured growth plate and articular chondrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15380039

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of specific insulin-like growth factor (IGF)-I and IGF-II receptors on cultured rabbit articular chondrocyte membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15380039

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discrete alterations of the insulin-like growth factor I molecule which alter its affinity for insulin-like growth factor-binding proteins result in changes in bioactivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15380039

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor (IGF) binding proteins and insulin-like growth factor secretion by cultured chondrocyte cells: identification, characterization and ontogeny during cell differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15380039

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factors counteract the effect of interleukin 1β on type II phospholipase A2 expression and arachidonic acid release by rabbit articular chondrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15380039

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human osteoarthritic chondrocytes possess an increased number of insulin-like growth factor 1 binding sites but are unresponsive to its stimulation. Possible role of IGF-1-binding proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/15380039

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor binding proteins (IGF-BPs) in bovine articular and ovine growth-plate chondrocyte cultures: their regulation by IGFs and modulation of proteoglycan synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15380039

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and characterization of insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), and IGFBP proteases in human synovial fluid

1 reference

https://pubmed.ncbi.nlm.nih.gov/15380039

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-like growth factor (IGF) receptor, IGF-I, interleukin-1 beta (IL-1 beta), and IL-6 mRNA expression in osteoarthritic and normal human cartilage

1 reference

https://pubmed.ncbi.nlm.nih.gov/15380039

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Normal expression of type 1 insulin-like growth factor receptor by human osteoarthritic chondrocytes with increased expression and synthesis of insulin-like growth factor binding proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/15380039

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Production of binding proteins and role of the insulin-like growth factor I binding protein 3 in human articular cartilage explants

1 reference

https://pubmed.ncbi.nlm.nih.gov/15380039

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Local disruption of the insulin-like growth factor system in the arthritic joint

1 reference

https://pubmed.ncbi.nlm.nih.gov/15380039

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related decline in chondrocyte response to insulin-like growth factor-I: the role of growth factor binding proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/15380039

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced repair of extensive articular defects by insulin-like growth factor-I-laden fibrin composites

1 reference

https://pubmed.ncbi.nlm.nih.gov/15380039

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The insulin-like growth factors (IGFs) I and II bind to articular cartilage via the IGF-binding proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/15380039

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autocrine stimulation by insulin-like growth factor 1 and insulin-like growth factor 2 mediates chondrocyte survival in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/15380039

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical objectives for cartilage repair

1 reference

https://pubmed.ncbi.nlm.nih.gov/15380039

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of the expression of matrix metalloproteinase and tissue inhibitors of metalloproteinases by TGF-beta1 and IGF-1 in primary human articular and bovine nasal chondrocytes stimulated with TNF-alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/15380039

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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