Animal models of copper-associated liver disease (Q24799557)

Localization of a recessive gene for North American Indian childhood cirrhosis to chromosome region 16q22-and identification of a shared haplotype

Europe PubMed Central

title

Animal models of copper-associated liver disease (English)

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I Carmen Fuentealba

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Enrique M Aburto

series ordinal

2

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publication date

3 April 2003

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published in

Comparative Hepatology

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volume

2

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issue

1

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page(s)

5

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cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

hCTR1: a human gene for copper uptake identified by complementation in yeast

7 April 2017

1 reference

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Identification of a new copper metabolism gene by positional cloning in a purebred dog population

7 April 2017

1 reference

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Identification and functional expression of HAH1, a novel human gene involved in copper homeostasis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Morphologic and chemical studies on a murine mutation (toxic milk mice) resulting in hepatic copper toxicosis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

The LEC rat has a deletion in the copper transporting ATPase gene homologous to the Wilson disease gene

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Autoimmune hepatitis and overlap syndromes

7 April 2017

1 reference

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The molecular basis of copper homeostasis copper-related disorders

28 September 2017

1 reference

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Induction, regulation, degradation, and biological significance of mammalian metallothioneins.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

A perspective on copper and liver disease in the dog.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Localization of the Wilson's disease protein in human liver.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Non-Indian childhood cirrhosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

A delicate balance: homeostatic control of copper uptake and distribution

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Early childhood cirrhoses (ECC) in Germany between 1982 and 1994 with special consideration of copper etiology.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

The Fifth Carlos E. Rubio Memorial Lecture. Sclerosing cholangitis: pathogenesis, pathology, and practice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

New knowledge of genetic pathogenesis of hemochromatosis and Wilson's disease.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Idiopathic copper toxicosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Role of copper in Indian childhood cirrhosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Haplotype and mutation analysis in Japanese patients with Wilson disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Chronic hepatitis: a retrospective study in 34 dogs.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Hepatic iron deprivation prevents spontaneous development of fulminant hepatitis and liver cancer in Long-Evans Cinnamon rats

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Wilson disease: genetic basis of copper toxicity and natural history

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Wilson disease and idiopathic copper toxicosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Genetic and molecular basis for copper toxicity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Liver copper storage and transport during development: implications for cytotoxicity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Copper biochemistry and molecular biology

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Copper-associated hepatopathies in dogs

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Feline cholangiohepatitis complex

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Wilson's disease: a new gene and an animal model for an old disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Chronic copper poisoning in sheep. A review of the literature

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Absorption, transport, and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Biliary copper excretion by hepatocyte lysosomes in the rat. Major excretory pathway in experimental copper overload

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Spontaneous hepatic copper accumulation in Long-Evans Cinnamon rats with hereditary hepatitis. A model of Wilson's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Copper transport: an overview

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

69 Overview of metallothionein

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Hepatocellular carcinoma in a case of Wilson's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Wilson's disease. A treatable liver disease in children

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

How does copper get into bile? New insights into the mechanism(s) of hepatobiliary copper transport

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Copper transport and its alterations in Menkes and Wilson diseases.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

The copper chaperone Atox1 in canine copper toxicosis in Bedlington terriers

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Metal (molybdenum, copper) accumulation and retention in brain, pituitary and other organs of ammonium tetrathiomolybdate-treated sheep.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Copper toxicosis in sheep: a case report.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Copper toxicity in confinement-housed ram lambs

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Wilson's disease in patients presenting with liver disease: a diagnostic challenge.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

The toxic milk mouse is a murine model of Wilson disease

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

The LEC rat: a model for human hepatitis, liver cancer, and much more.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

An ultrastructural and morphometric study of the liver of normal and copper-poisoned sheep

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Experimental chronic copper toxicity in sheep. Histological and histochemical changes during the development of the lesions in the liver.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Chronic active hepatitis in 26 Doberman pinschers.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

An ultrastructural study of the kidney of normal, copper poisoned and thiomolybdate-treated sheep

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

A study of the role of metallothionein in the inherited copper toxicosis of dogs

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Regulation of aortic CuZn-superoxide dismutase with copper. Caeruloplasmin and albumin re-activate and transfer copper to the enzyme in culture

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

The role of glutathione in copper metabolism and toxicity.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Histochemical study of the accumulation of copper in the liver of sheep

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Experimental chronic copper toxicity in sheep. Changes that follow the cessation of dosing at the onset of haemolysis

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Clinical characteristics of primary biliary cirrhosis: a report of 45 cases

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Copper-associated liver disease in North Ronaldsay sheep: a possible animal model for non-Wilsonian hepatic copper toxicosis of infancy and childhood

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

ATP6H, a subunit of vacuolar ATPase involved in metal transport: evaluation in canine copper toxicosis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Liver transplantation in the Nordic countries, 1982-1998: changes of indications and improving results

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Biliary excretion of copper in LEC rat after introduction of copper transporting P-type ATPase, ATP7B.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Genetic mapping of the copper toxicosis locus in Bedlington terriers to dog chromosome 10, in a region syntenic to human chromosome region 2p13-p16.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

The LEC Rat Possesses Reduced Hepatic Selenium, Contributing to the Severity of Spontaneous Hepatitis and Sensitivity to Carcinogenesis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Development of intralobular bile ductules after spontaneous hepatitis in Long-Evans mutant rats.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Treatment of Wilson's disease with ammonium tetrathiomolybdate. I. Initial therapy in 17 neurologically affected patients.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

The Wilson disease gene: spectrum of mutations and their consequences

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=156612

Primary biliary cirrhosis

28 November 2018

1 reference

12 December 2020

Copper in plasma reflects its status and subsequent toxicity in the liver of LEC rats

1 reference

12 December 2020

Effects of cyclosporin-A and D-penicillamine on the development of hepatitis and the production of antibody to protein disulfide isomerase in LEC rats

1 reference

12 December 2020

Chronic lymphocytic cholangitis in three cats

1 reference

12 December 2020

Pathobiology of copper-induced injury in Bedlington terriers: ultrastructural and microanalytical studies

1 reference

12 December 2020

Copper associated acute hepatic failure in a dog

1 reference

12 December 2020

Physiologic function of the Wilson disease gene product, ATP7B

1 reference

12 December 2020

Hepatopathy associated with excessive hepatic copper in a Siamese cat

1 reference

12 December 2020

Initial therapy of patients with Wilson's disease with tetrathiomolybdate

1 reference

12 December 2020

Polioencephalomalacia associated with chronic copper poisoning in a Suffolk ram lamb

1 reference

12 December 2020

Diagnosis and treatment of Wilson's disease

1 reference

12 December 2020

Hereditary copper toxicosis in West Highland white terriers

1 reference

12 December 2020

Histomorphological and immunohistochemical studies of chronic active hepatitis in Doberman Pinschers

1 reference

12 December 2020

The canine copper toxicosis locus is not syntenic with ATP7B or ATX1 and maps to a region showing homology to human 2p21

1 reference

12 December 2020

Hepatitis and Increased Copper Levels in a Dalmatian

1 reference

12 December 2020

Autoimmune tests in primary biliary cirrhosis

1 reference

12 December 2020

1 reference

12 December 2020

Zinc treatment of Wilson's disease

1 reference

12 December 2020

Cytochemical detection of inherited copper toxicosis of Bedlington terriers

1 reference

12 December 2020

Lesions of subclinical doberman hepatitis

1 reference

12 December 2020

Survey of copper granules in liver biopsy specimens from various liver abnormalities other than Wilson's disease and biliary diseases

1 reference

12 December 2020

The toxic milk mutation, tx, which results in a condition resembling Wilson disease in humans, is linked to mouse chromosome 8

1 reference

12 December 2020

Use of zinc acetate to treat copper toxicosis in dogs

1 reference

12 December 2020

The effectiveness of using supplementary zinc and molybdenum to reduce the copper content in the liver of hypercuprotic sheep

1 reference

12 December 2020

Pleiotropic effect of LEC mutation: a rodent model of Wilson's disease

1 reference

12 December 2020

Copper toxicosis in sibling ferrets

1 reference

12 December 2020

Copper in ruminants. Review

1 reference

12 December 2020

Occurrence of autoimmune antibodies to liver microsomal proteins associated with lethal hepatitis in LEC rats: effects of TJN-101 ((+)-(6S,7S,R-biar)- 5,6,7,8-tetrahydro-1,2,3,12-tetramethoxy-6,7-dimethyl-10,11- methylenedioxy-6-dibenzo[a,c]cyclooct

1 reference

12 December 2020

Metallothionein and copper in liver disease with copper retention--a histopathological study

1 reference

12 December 2020

Value of histochemical stains for copper in the diagnosis of Wilson's disease

1 reference

12 December 2020

Intravenous administration of thiomolybdate for the prevention and treatment of chronic copper poisoning in sheep

1 reference

12 December 2020

Hereditary hepatitis of LEC rats is controlled by a single autosomal recessive gene

1 reference

12 December 2020

Hepatic copper content is normal in early primary biliary cirrhosis and primary sclerosing cholangitis

1 reference

12 December 2020

An array of mitochondrial alterations in the hepatocytes of Long-Evans Cinnamon rats

1 reference

12 December 2020

Clinical, morphologic, and chemical studies on copper toxicosis of Bedlington Terriers

1 reference

12 December 2020

The Long Evans Cinnamon (LEC) rat develops hepatocellular damage in the absence of antimicrosomal antibodies

1 reference

12 December 2020

The liver in the inherited copper disease of Bedlington terriers

1 reference

12 December 2020

Primary biliary cirrhosis

1 reference

12 December 2020

Clinico-pathological studies of LEC rats with hereditary hepatitis and hepatoma in the acute phase of hepatitis

1 reference

12 December 2020

Experimental chronic copper toxicity in sheep. Biochemical and haematological studies during the development of lesions in the liver

1 reference

12 December 2020

Copper poisoning in sheep from North Ronaldsay maintained on a diet of terrestrial herbage

1 reference

12 December 2020

Use of 2,3,2-tetramine as a hepatic copper chelating agent for treatment of copper hepatotoxicosis in Bedlington terriers

1 reference

12 December 2020

Hepatic copper concentrations in purebred and mixed-breed dogs

1 reference

12 December 2020

Efficacy of liver transplantation in patients with primary biliary cirrhosis

1 reference

12 December 2020

Hepatitis and copper accumulation in Skye terriers

1 reference

12 December 2020

Intracellular distribution of the Wilson's disease gene product (ATPase7B) after in vitro and in vivo exogenous expression in hepatocytes from the LEC rat, an animal model of Wilson's disease

1 reference

12 December 2020

1 reference

12 December 2020

In vitro modeling of liver membrane copper transport

1 reference

12 December 2020

Chronic active hepatitis in Doberman pinschers

1 reference

12 December 2020

Toxicity of penicillamine

1 reference

12 December 2020

The use of trientine in preventing the effects of interrupting penicillamine therapy in Wilson's disease

1 reference

12 December 2020