Cytoplasmic p21WAF1/CIP1 expression is correlated with HER-2/ neu in breast cancer and is an independent predictor of prognosis (Q24802985)

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object named as

Adrian L Harris

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author name string

Zoë E Winters

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Russell D Leek

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Chris J Norbury

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

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language of work or name

English

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publication date

2003

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published in

Breast Cancer Research

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volume

5

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issue

6

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page(s)

R242-9

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cites work

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p21(waf) correlates with DNA replication but not with prognosis in invasive breast cancer

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Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase

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Cellular survival: a play in three Akts

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Radiation-induced cell cycle arrest compromised by p21 deficiency

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Correlation between immunohistochemistry (HercepTest) and fluorescence in situ hybridization (FISH) for HER-2 in 426 breast carcinomas from 37 centres.

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p21WAF1 expression in invasive breast cancer and its association with p53, AP-2, cell proliferation, and prognosis

28 September 2017

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HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

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Overexpression of HER-2 as a resistance mechanism to hormonal therapy for breast cancer

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Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

28 September 2017

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Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation

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Cytoplasmic displacement of cyclin E-cdk2 inhibitors p21Cip1 and p27Kip1 in anchorage-independent cells

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Expression of a novel form of p21Cip1/Waf1 in UV-irradiated and transformed cells

28 September 2017

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Nuclear accumulation of p21Cip1 at the onset of mitosis: a role at the G2/M-phase transition

28 September 2017

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The cyclin-dependent kinase inhibitor p21CIP/WAF is a positive regulator of insulin-like growth factor I-induced cell proliferation in MCF-7 human breast cancer cells

28 September 2017

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Mechanisms and consequences of activation of protein kinase B/Akt

30 May 2018

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Increased level of p21 in human ovarian tumors is associated with increased expression of cdk2, cyclin A and PCNA.

30 May 2018

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Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin).

21 January 2018

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p21WAF1 and p53 immunohistochemical expression in breast carcinoma may predict therapeutic response to adjuvant treatment

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p53 regulates Cdc2 independently of inhibitory phosphorylation to reinforce radiation-induced G2 arrest in human cells

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Evaluation of HER-2/neu immunohistochemical assay sensitivity and scoring on formalin-fixed and paraffin-processed cell lines and breast tumors: a comparative study involving results from laboratories in 21 countries

21 January 2018

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Multiple imputation of missing blood pressure covariates in survival analysis

21 January 2018

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WAF1/CIP1 protein expression in human breast tumors

21 January 2018

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The phosphatidylinositol 3-kinase/AKT signal transduction pathway plays a critical role in the expression of p21WAF1/CIP1/SDI1 induced by cisplatin and paclitaxel

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/14580260