Science review: carnitine in the treatment of valproic acid-induced toxicity - what is the evidence? (Q24813193)

5 July 2017

1 reference

2 October 2023

Science review: carnitine in the treatment of valproic acid-induced toxicity - what is the evidence? (English)

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5 July 2017

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19 November 2019

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15 August 2020

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24 January 2021

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inferred from abstract

vitamin B

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vitamin B deficiency

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author

Philippe E R Lheureux

series ordinal

1

object named as

Philippe E R Lheureux

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5 July 2017

2

Andrea Penaloza

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5 July 2017

3

Soheil Zahir

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5 July 2017

4

Mireille Gris

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5 July 2017

language of work or name

English

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publication date

10 June 2005

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5 July 2017

5 October 2005

8 references

14 March 2019

19 March 2019

7 November 2019

19 November 2019

15 August 2020

24 January 2021

11 August 2023

2 October 2023

10 references

5 July 2017

14 March 2019

19 March 2019

7 November 2019

19 November 2019

4 June 2020

15 August 2020

24 January 2021

11 August 2023

2 October 2023

9

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5 July 2017

issue

5

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5 July 2017

page(s)

431-440

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Muscle Carnitine Palmityltransferase Deficiency and Myoglobinuria

5 July 2017

cites work

1 reference

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Mitochondrial metabolism of valproic acid

7 April 2017

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Comparison of clinical, magnetic resonance and evoked potentials data in a case of valproic-acid-related hyperammonemic coma

7 April 2017

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28 September 2017

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Valproate: past, present, and future.

28 September 2017

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Carnitine metabolism and deficit--when supplementation is necessary?

28 September 2017

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Valproate-induced hyperammonemic encephalopathy

28 September 2017

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Valproic acid toxicity: overview and management

28 September 2017

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Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy

28 September 2017

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Delayed valproic acid toxicity: a retrospective case series

28 September 2017

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Hyperammonemia and coma without hepatic dysfunction induced by valproate therapy

28 September 2017

1 reference

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Valproic acid overdose and haemodialysis

28 September 2017

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Multicenter case series of valproic acid ingestion: serum concentrations and toxicity

28 September 2017

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The role of carnitine supplementation during valproic acid therapy

28 September 2017

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Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action

28 September 2017

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Acute hepatic failure associated with valproic acid in children. Report of 3 cases

28 September 2017

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Valproic acid hepatic fatalities. III. U.S. experience since 1986.

28 September 2017

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Life threatening intoxication with sodium valproate

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297603

Plasma and hepatic carnitine and coenzyme A pools in a patient with fatal, valproate induced hepatotoxicity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297603

Clinical pharmacokinetics of valproic acid

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297603

Dicarboxylic acids and the lipid metabolism.

28 September 2017

1 reference

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Concentration-effect relationships of valproic acid

28 September 2017

1 reference

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Carnitine as an essential nutrient

28 September 2017

1 reference

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Valproate: an updated review.

28 September 2017

1 reference

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Carnitine, valproate, and toxicity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297603

Effect of valproate on the metabolism of the central nervous system.

28 September 2017

1 reference

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Valproate therapy does not deplete carnitine levels in otherwise healthy children.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297603

Effect of L-carnitine supplementation on acute valproate intoxication

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297603

Valproate (VPA) metabolites in various clinical conditions of probable VPA-associated hepatotoxicity.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297603

Severe hepatotoxicity during valproate therapy: an update and report of eight new fatalities.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297603

Valproate increases glutaminase and decreases glutamine synthetase activities in primary cultures of rat brain astrocytes.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297603

Fluorinated analogues as mechanistic probes in valproic acid hepatotoxicity: hepatic microvesicular steatosis and glutathione status

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297603

Decreased serum carnitine in valproate induced Reye syndrome

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297603

Valproate-induced hepatic injury: analyses of 23 fatal cases

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297603

Secondary hyperammonaemia: a possible mechanism for valproate encephalopathy

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297603

Hepatic and renal contributions to valproic acid-induced hyperammonemia

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297603

Serum carnitine during valproic acid therapy

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297603

Nutritional influence on serum ammonia in young patients receiving sodium valproate

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297603

Valproic acid associated abnormalities of carnitine metabolism

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297603

Metabolic changes during treatment with valproate in humans: implication for untoward weight gain

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297603

Cerebral edema following acute sodium valproate overdose

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297603

Successful use of hemodialysis in acute valproic acid intoxication

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297603

Haemodialysis, L-carnitine therapy and valproic acid overdose

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297603

Metabolic viability and pharmaco-toxicological reactivity of cryopreserved human precision-cut renal cortical slices

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297603

Hyperammonemic encephalopathy induced by a combination of valproate and pivmecillinam

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297603

Carnitine level in Chinese epileptic patients taking sodium valproate

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297603

Effect of L-carnitine treatment for valproate-induced hepatotoxicity

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297603

Effect of L-carnitine treatment for valproate-induced hepatotoxicity

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1297603

Diet- and valproate-induced transient hyperammonemia: effect of L-carnitine.

28 November 2018

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Biochemical basis of sodium valproate hepatotoxicity and renal tubular disorder: time dependence of peroxidative injury

28 November 2018

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The renal origin of sodium valproate-induced hyperammonemia in fasting humans.

28 November 2018

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Sodium valproate-induced hyperammonemia in the rat: role of the kidney.

28 November 2018

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Successful treatment by direct hemoperfusion of coma possibly resulting from mitochondrial dysfunction in acute valproate intoxication

28 November 2018

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12 December 2020

l-Carnitine Supplementation in Childhood Epilepsy: Current Perspectives

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12 December 2020

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12 December 2020

[Hepatic diseases caused by drugs]

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12 December 2020

Reduction in blood free carnitine levels in association with changes in sodium valproate (VPA) disposition in epileptic patients treated with VPA and other anti-epileptic drugs

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12 December 2020

The effect of carnitine supplementation in valproate-induced hyperammonaemia

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12 December 2020

Delayed toxicity following ingestion of enteric-coated divalproex sodium (Epival)

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12 December 2020

Acute valproate intoxication: biochemical investigations and hemodialysis treatment

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12 December 2020

Carnitine deficiency: a possible mechanism for valproate hepatotoxicity

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12 December 2020

Hepatotoxicity of sodium valproate

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12 December 2020

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12 December 2020

Study of reasons for cessation of therapy with perhexiline maleate, sodium valproate and labetalol in the intensified adverse reaction reporting scheme

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12 December 2020

Muscle carnitine deficiency in patients using valproic acid

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12 December 2020

Influence of valproic acid on hepatic carbohydrate and lipid metabolism

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12 December 2020

Alteration of renal carnitine metabolism by anticonvulsant treatment

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12 December 2020

Reversal of valproic acid-associated impairment of carnitine uptake in cultured human skin fibroblasts

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12 December 2020

Valproate metabolites in high-dose valproate plus phenytoin therapy

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12 December 2020

Valproate treatment and carnitine deficiency

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12 December 2020

Carnitine deficiency with valproate therapy

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12 December 2020

The hepatotoxicity of valproic acid and its metabolites in rats. I. Toxicologic, biochemical and histopathologic studies

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12 December 2020

Valproic acid overdose and L-carnitine therapy

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12 December 2020

Valproylcarnitine: a novel drug metabolite identified by fast atom bombardment and thermospray liquid chromatography-mass spectrometry

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12 December 2020

Fatal hepatotoxicity in child on phenobarbitone and sodium valproate

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12 December 2020

Carnitine status in Reye and Reye-like syndromes

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12 December 2020

Valproate metabolites and hepatotoxicity in an epileptic population

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12 December 2020

Sodium valproate in the induction of unusual hepatotoxicity

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12 December 2020

A case of valproate-associated hepatotoxicity treated with L-carnitine

1 reference

12 December 2020

Carnitine deficiency and hyperammonemia associated with valproic acid therapy

1 reference

12 December 2020

Delayed peak serum valproic acid in massive divalproex overdose--treatment with charcoal hemoperfusion

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12 December 2020

Identifiers

DOI

10.1186/CC3742

1 reference

Dimensions Publication ID

5 July 2017

0 references

1 reference

5 July 2017

1 reference