Phosphodiesterase type 4 expression and anti-proliferative effects in human pulmonary artery smooth muscle cells (Q25255769)

6 July 2017

Phosphodiesterase type 4 expression and anti-proliferative effects in human pulmonary artery smooth muscle cells (English)

1 reference

6 July 2017

Ellena J Growcott

1

1 reference

6 July 2017

Karen G Spink

2

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6 July 2017

Xiaohui Ren

3

1 reference

6 July 2017

Saliha Afzal

4

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6 July 2017

Kathy H Banner

5

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6 July 2017

John Wharton

6

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6 July 2017

language of work or name

English

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publication date

19 January 2006

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6 July 2017

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6 July 2017

7

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6 July 2017

1

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page(s)

9

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https://scigraph.springernature.com/pub.10.1186/1465-9921-7-9

6 July 2017

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cites work

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Cyclic nucleotide phosphodiesterase activity, expression, and targeting in cells of the cardiovascular system

7 April 2017

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Cyclic AMP inhibited proliferation of human aortic vascular smooth muscle cells, accompanied by induction of p53 and p21

7 April 2017

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AKAP signalling complexes: focal points in space and time

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Reversal of experimental pulmonary hypertension by PDGF inhibition

7 April 2017

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Prednisolone inhibits proliferation of cultured pulmonary artery smooth muscle cells of patients with idiopathic pulmonary arterial hypertension

28 September 2017

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Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension

28 September 2017

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Cellular and molecular mechanisms of pulmonary vascular remodeling: role in the development of pulmonary hypertension

28 September 2017

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Matrix metalloproteinase-2 cleavage of adrenomedullin produces a vasoconstrictor out of a vasodilator

28 September 2017

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28 September 2017

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Modulation of matrix metalloproteinase production from human lung fibroblasts by type 4 phosphodiesterase inhibitors

28 September 2017

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Prostacyclin and its analogues in the treatment of pulmonary hypertension

28 September 2017

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PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization

28 September 2017

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In vivo efficacy in airway disease models of roflumilast, a novel orally active PDE4 inhibitor

28 September 2017

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Elevation of intracellular cAMP inhibits growth factor-mediated matrix metalloproteinase-9 induction and keratinocyte migration.

28 September 2017

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Inhibition of platelet-derived growth factor-induced mitogenesis by phosphodiesterase 3 inhibitors: role of protein kinase A in vascular smooth muscle cell mitogenesis

28 September 2017

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Ursolic acid-induced down-regulation of MMP-9 gene is mediated through the nuclear translocation of glucocorticoid receptor in HT1080 human fibrosarcoma cells

28 September 2017

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Cyclic nucleotide phosphodiesterases and vascular smooth muscle

28 September 2017

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Prostacyclin induces apoptosis of vascular smooth muscle cells by a cAMP-mediated inhibition of extracellular signal-regulated kinase activity and can counteract the mitogenic activity of endothelin-1 or basic fibroblast growth factor

28 September 2017

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Cyclic AMP-mobilizing agents and glucocorticoids modulate human smooth muscle cell migration

31 May 2018

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NF-Y and Sp1 cooperate for the transcriptional activation and cAMP response of human tissue inhibitor of metalloproteinases-2.

31 May 2018

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Phosphodiesterase isozymes: molecular targets for novel antiasthma agents

31 May 2018

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Tailoring cAMP-signalling responses through isoform multiplicity

31 May 2018

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Differential effects of stable prostacyclin analogs on smooth muscle proliferation and cyclic AMP generation in human pulmonary artery

31 May 2018

1 reference

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cAMP phosphodiesterase inhibitors potentiate effects of prostacyclin analogs in hypoxic pulmonary vascular remodeling

21 January 2018

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Characterisation of cyclic nucleotide phosphodiesterase isoforms in the media layer of the main pulmonary artery

21 January 2018

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Gelatinase expression in pulmonary arteries during experimental pulmonary hypertension

21 January 2018

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Inhibition of matrix metalloproteinases by lung TIMP-1 gene transfer limits monocrotaline-induced pulmonary vascular remodeling in rats

21 January 2018

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Monocyte membrane type 1-matrix metalloproteinase. Prostaglandin-dependent regulation and role in metalloproteinase-2 activation

21 January 2018

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Antiproliferative effects of phosphodiesterase type 5 inhibition in human pulmonary artery cells

21 January 2018

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Roflumilast--an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trial

21 January 2018

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Antiremodeling effects of iloprost and the dual-selective phosphodiesterase 3/4 inhibitor tolafentrine in chronic experimental pulmonary hypertension

21 January 2018

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Inhaled iloprost reverses vascular remodeling in chronic experimental pulmonary hypertension

21 January 2018

1 reference

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The effect of selective phosphodiesterase isoenzyme inhibition on neutrophil function in vitro

21 January 2018

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Phosphodiesterase 4 inhibitor cilomilast inhibits fibroblast-mediated collagen gel degradation induced by tumor necrosis factor-alpha and neutrophil elastase

21 January 2018

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Evidence for a role of phosphodiesterase 4 in lipopolysaccharide-stimulated prostaglandin E2 production and matrix metalloproteinase-9 activity in human amniochorionic membranes.

21 January 2018

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Anti-inflammatory and immunomodulatory potential of the novel PDE4 inhibitor roflumilast in vitro.

21 January 2018

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Phosphodiesterase isoforms in the pulmonary arterial circulation of the rat: changes in pulmonary hypertension

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1386664

Immunohistochemical study of endothelin-1 and matrix metalloproteinases in plexogenic pulmonary arteriopathy

28 November 2018

1 reference

12 December 2020

Primary pulmonary hypertension

1 reference

12 December 2020

Differential type 4 cAMP-specific phosphodiesterase (PDE4) expression and functional sensitivity to PDE4 inhibitors among rats, monkeys and humans

1 reference

12 December 2020

Identification of PDE isozymes in human pulmonary artery and effect of selective PDE inhibitors

1 reference

12 December 2020

Phosphodiesterase inhibition improves agonist-induced relaxation of hypertensive pulmonary arteries

1 reference

12 December 2020

cAMP involvement in the expression of MMP-2 and MT-MMP1 metalloproteinases in human endothelial cells

1 reference

12 December 2020

Low-dose Systemic Phosphodiesterase Inhibitors Amplify the Pulmonary Vasodilatory Response to Inhaled Prostacyclin in Experimental Pulmonary Hypertension

1 reference

12 December 2020

Subthreshold doses of specific phosphodiesterase type 3 and 4 inhibitors enhance the pulmonary vasodilatory response to nebulized prostacyclin with improvement in gas exchange

1 reference

12 December 2020

Expression of phosphodiesterase 4D (PDE4D) is regulated by both the cyclic AMP-dependent protein kinase and mitogen-activated protein kinase signaling pathways. A potential mechanism allowing for the coordinated regulation of PDE4D activity and expr

1 reference

12 December 2020

Prostacyclin Analogues Differentially Inhibit Growth of Distal and Proximal Human Pulmonary Artery Smooth Muscle Cells

1 reference

12 December 2020

Synergistic inhibition of vascular smooth muscle cell migration by phosphodiesterase 3 and phosphodiesterase 4 inhibitors

1 reference

12 December 2020

Regression of hypertrophied rat pulmonary arteries in organ culture is associated with suppression of proteolytic activity, inhibition of tenascin-C, and smooth muscle cell apoptosis

1 reference

12 December 2020

Phosphodiesterase 4B2 is the predominant phosphodiesterase species and undergoes differential regulation of gene expression in human monocytes and neutrophils

1 reference

12 December 2020

Smooth muscle cell matrix metalloproteinases in idiopathic pulmonary arterial hypertension

1 reference

12 December 2020

Cl- current activation in choroid plexus epithelial cells involves a G protein and protein kinase A.

1 reference

https://api.crossref.org/works/10.1186%2F1465-9921-7-9

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1186/1465-9921-7-9

1 reference

Dimensions Publication ID

6 July 2017

1 reference

https://scigraph.springernature.com/pub.10.1186/1465-9921-7-9

9 September 2019

1 reference

6 July 2017

1 reference