Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis (Q26269821)

19

0 references

Qiangjun Zhou

Qiangjun Zhou

1

0 references

Aina E Cohen

Aina E Cohen

10

0 references

Jiajie Diao

Jiajie Diao

18

0 references

William I Weis

William I Weis

17

0 references

Henrik T Lemke

Henrik T Lemke

14

0 references

Axel T. Brunger

Axel T Brunger

20

0 references

Taulant Bacaj

3

Taulant Bacaj

0 references

Nicholas K. Sauter

9

Nicholas K Sauter

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author name string

Ying Lai

2

0 references

Minglei Zhao

4

0 references

Artem Y Lyubimov

5

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Monarin Uervirojnangkoorn

6

0 references

Oliver B Zeldin

7

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Aaron S Brewster

8

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S Michael Soltis

11

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Roberto Alonso-Mori

12

0 references

Matthieu Chollet

13

0 references

Richard A Pfuetzner

15

0 references

Ucheor B Choi

Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution

16

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language of work or name

English

0 references

publication date

3 September 2015

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published in

Nature

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volume

525

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issue

7567

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page(s)

62-7

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cites work

1 reference

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Neurotransmitter release: the last millisecond in the life of a synaptic vesicle

7 April 2017

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Lipid-anchored SNAREs lacking transmembrane regions fully support membrane fusion during neurotransmitter release

7 April 2017

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Cell biology of Ca2+-triggered exocytosis

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Dynamic Ca2+-dependent stimulation of vesicle fusion by membrane-anchored synaptotagmin 1

7 April 2017

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MolProbity: all-atom structure validation for macromolecular crystallography

7 April 2017

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Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release

7 April 2017

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Augmenting neurotransmitter release by enhancing the apparent Ca2+ affinity of synaptotagmin 1

7 April 2017

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Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins

7 April 2017

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Goniometer-based femtosecond crystallography with X-ray free electron lasers

7 April 2017

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Accurate macromolecular structures using minimal measurements from X-ray free-electron lasers

7 April 2017

1 reference

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Natively Inhibited Trypanosoma brucei Cathepsin B Structure Determined by Using an X-ray Laser

7 April 2017

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The structure of an Arf-ArfGAP complex reveals a Ca2+ regulatory mechanism

7 April 2017

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Structure of human synaptotagmin 1 C2AB in the absence of Ca2+ reveals a novel domain association

7 April 2017

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High resolution structure, stability, and synaptotagmin binding of a truncated neuronal SNARE complex

7 April 2017

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Three-dimensional structure of the complexin/SNARE complex

7 April 2017

1 reference

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Three-dimensional structure of the synaptotagmin 1 C2B-domain: synaptotagmin 1 as a phospholipid binding machine

7 April 2017

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Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution

7 April 2017

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Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold

7 April 2017

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Overview of the CCP4 suite and current developments

7 April 2017

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7 April 2017

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Phasercrystallographic software

7 April 2017

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Version 1.2 of the Crystallography and NMR system

7 April 2017

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Inference of macromolecular assemblies from crystalline state

7 April 2017

1 reference

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Protein production by auto-induction in high density shaking cultures

7 April 2017

1 reference

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Coot: model-building tools for molecular graphics

7 April 2017

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UCSF Chimera--a visualization system for exploratory research and analysis

7 April 2017

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PHENIX: building new software for automated crystallographic structure determination

7 April 2017

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7 April 2017

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

21 January 2018

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How synaptotagmin promotes membrane fusion.

7 April 2017

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SNAREpins: minimal machinery for membrane fusion

7 April 2017

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A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis

7 April 2017

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Autonomous function of synaptotagmin 1 in triggering synchronous release independent of asynchronous release

7 April 2017

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Synaptotagmin I functions as a calcium regulator of release probability

7 April 2017

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A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding

7 April 2017

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Syntaxin: a synaptic protein implicated in docking of synaptic vesicles at presynaptic active zones

7 April 2017

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Synaptotagmin-mediated bending of the target membrane is a critical step in Ca(2+)-regulated fusion

7 April 2017

1 reference

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Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse

7 April 2017

1 reference

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Super-resolution biomolecular crystallography with low-resolution data

7 April 2017

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Enabling X-ray free electron laser crystallography for challenging biological systems from a limited number of crystals

7 April 2017

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Data Exploration Toolkit for serial diffraction experiments

28 September 2017

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Improved crystal orientation and physical properties from single-shot XFEL stills

28 September 2017

1 reference

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A distinct tethering step is vital for vacuole membrane fusion

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607316

Calcium sensitive ring-like oligomers formed by synaptotagmin

28 September 2017

1 reference

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Complexin inhibits spontaneous release and synchronizes Ca2+-triggered synaptic vesicle fusion by distinct mechanisms

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607316

Conformational dynamics of calcium-triggered activation of fusion by synaptotagmin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607316

Synaptotagmin interaction with SNAP-25 governs vesicle docking, priming, and fusion triggering.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607316

The synaptotagmin 1 linker may function as an electrostatic zipper that opens for docking but closes for fusion pore opening.

28 September 2017

1 reference

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New Python-based methods for data processing

28 September 2017

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Processive ATP-driven substrate disassembly by the N-ethylmaleimide-sensitive factor (NSF) molecular machine

28 September 2017

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Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion

28 September 2017

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Studying calcium-triggered vesicle fusion in a single vesicle-vesicle content and lipid-mixing system

28 September 2017

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Controlling synaptotagmin activity by electrostatic screening

28 September 2017

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Single reconstituted neuronal SNARE complexes zipper in three distinct stages

28 September 2017

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Energetics of stalk intermediates in membrane fusion are controlled by lipid composition

28 September 2017

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Reconstituted synaptotagmin I mediates vesicle docking, priming, and fusion

28 September 2017

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Post-translational modifications and lipid binding profile of insect cell-expressed full-length mammalian synaptotagmin 1

28 September 2017

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In vitro system capable of differentiating fast Ca2+-triggered content mixing from lipid exchange for mechanistic studies of neurotransmitter release

28 September 2017

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Distinct roles for two synaptotagmin isoforms in synchronous and asynchronous transmitter release at zebrafish neuromuscular junction

28 September 2017

1 reference

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Single-molecule FRET-derived model of the synaptotagmin 1-SNARE fusion complex

28 September 2017

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Crystallographic model quality at a glance

28 September 2017

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The Janus-faced nature of the C(2)B domain is fundamental for synaptotagmin-1 function.

28 September 2017

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Electrostatic interaction of internal Mg2+ with membrane PIP2 Seen with KCNQ K+ channels

28 September 2017

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Membrane-bound orientation and position of the synaptotagmin C2B domain determined by site-directed spin labeling

28 September 2017

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Potential for biomolecular imaging with femtosecond X-ray pulses

28 September 2017

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Synaptotagmin C2B domain regulates Ca2+-triggered fusion in vitro: critical residues revealed by scanning alanine mutagenesis

28 September 2017

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A quaternary SNARE-synaptotagmin-Ca2+-phospholipid complex in neurotransmitter release

31 May 2018

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Conserved prefusion protein assembly in regulated exocytosis

31 May 2018

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Linker length and composition influence the flexibility of Oct-1 DNA binding

31 May 2018

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Synaptotagmin: a calcium sensor on the synaptic vesicle surface

31 May 2018

1 reference

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The principle of membrane fusion in the cell (Nobel lecture).

31 May 2018

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Synaptotagmin-1, -2, and -9: Ca(2+) sensors for fast release that specify distinct presynaptic properties in subsets of neurons

21 January 2018

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Synaptotagmin I functions as a calcium sensor to synchronize neurotransmitter release.

21 January 2018

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Synaptotagmin increases the dynamic range of synapses by driving Ca²+-evoked release and by clamping a near-linear remaining Ca²+ sensor.

21 January 2018

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A gain-of-function mutation in synaptotagmin-1 reveals a critical role of Ca2+-dependent soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex binding in synaptic exocytosis.

21 January 2018

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Ca(2+)-independent syntaxin binding to the C(2)B effector region of synaptotagmin

21 January 2018

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Imaging biological specimens with high-intensity soft x rays

21 January 2018

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Synaptotagmin-1 Docks Secretory Vesicles to Syntaxin-1/SNAP-25 Acceptor Complexes

21 January 2018

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Monitoring synaptic transmission in primary neuronal cultures using local extracellular stimulation

21 January 2018

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Mutations in the second C2 domain of synaptotagmin disrupt synaptic transmission at Drosophila neuromuscular junctions

21 January 2018

1 reference

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Mechanism of phospholipid binding by the C2A-domain of synaptotagmin I

28 November 2018

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12 December 2020

Close membrane-membrane proximity induced by Ca(2+)-dependent multivalent binding of synaptotagmin-1 to phospholipids

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12 December 2020

Synaptotagmin has an essential function in synaptic vesicle positioning for synchronous release in addition to its role as a calcium sensor

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PubMed

12 December 2020

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12 December 2020

Identifiers

DOI

10.1038/NATURE14975

1 reference

Dimensions Publication ID

1052202020

0 references

1 reference

1 reference

PubMed publication ID

26280336

1 reference