Cardiovascular Actions and Therapeutic Potential of Tetramethylpyrazine (Active Component Isolated from Rhizoma Chuanxiong): Roles and Mechanisms (Q26744567)

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English	Cardiovascular Actions and Therapeutic Potential of Tetramethylpyrazine (Active Component Isolated from Rhizoma Chuanxiong): Roles and Mechanisms	scientific article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27314011%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

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Europe PubMed Central

30 July 2022

26 October 2022

Cardiovascular Actions and Therapeutic Potential of Tetramethylpyrazine (Active Component Isolated from Rhizoma Chuanxiong): Roles and Mechanisms (English)

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27314011%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

atherosclerosis

1 reference

22 October 2019

1 reference

17 September 2019

1 reference

22 October 2019

1 reference

22 October 2019

reperfusion injury

1 reference

PubMed publication ID

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27314011%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

author name string

Ming Guo

1

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27314011%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

Dazhuo Shi

3

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14 March 2020

language of work or name

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publication date

23 May 2016

7 references

22 March 2019

17 June 2019

17 September 2019

22 October 2019

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27314011%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

30 July 2022

26 October 2022

BioMed Research International

8 references

22 March 2019

17 June 2019

17 September 2019

22 October 2019

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27314011%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

30 July 2022

26 October 2022

2016

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27314011%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

2430329

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27314011%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

copyright license

Creative Commons Attribution 4.0 International

6 references

Europe PubMed Central

22 March 2019

Europe PubMed Central

17 June 2019

Europe PubMed Central

17 September 2019

Europe PubMed Central

22 October 2019

Europe PubMed Central

30 July 2022

Europe PubMed Central

26 October 2022

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0 references

on focus list of Wikimedia project

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Induction of human CYP3A4 by huperzine A, ligustrazine and oridonin through pregnane X receptor-mediated pathways

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28 September 2017

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Pharmacokinetics of ligustrazine ethosome patch in rats and anti-myocardial ischemia and anti-ischemic reperfusion injury effect

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Antioxidative effect of the herbal remedy Qin Huo Yi Hao and its active component tetramethylpyrazine on high glucose-treated endothelial cells.

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28 September 2017

Role of endothelin-1 in hypertension and vascular disease

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28 September 2017

Endogenous plasma endothelin concentrations and coronary circulation in patients with mild dilated cardiomyopathy

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Vascular biology of endothelin.

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28 September 2017

Inhibition of vasoconstriction by tetramethylpyrazine: does it act by blocking the voltage-dependent Ca channel?

1 reference

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28 September 2017

TMPDP, a tetramethylpyrazine derivative, protects vascular endothelial cells from oxidation damage by hydrogen peroxide.

1 reference

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31 May 2018

Antithrombotic/antiplatelet activity of tetramethylpyrazine

1 reference

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31 May 2018

Specific inhibiting characteristics of tetramethylpyrazine, one of the active ingredients of the Chinese herbal medicine 'Chuanxiong,' on platelet thrombus formation under high shear rates

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21 January 2018

Pharmacokinetics of tetramethylpyrazine in rat blood and brain using microdialysis

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21 January 2018

Brain microdialysate, CSF and plasma pharmacokinetics of ligustrazine hydrochloride in rats after intranasal and intravenous administration

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21 January 2018

An automated dual-gradient liquid chromatography-MS/MS method for the simultaneous determination of ferulic acid, ligustrazine and ligustilide in rat plasma and its application to a pharmacokinetic study.

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21 January 2018

Synergistic interaction between the Ligusticum chuanxiong constituent butylidenephthalide and the nitric oxide donor sodium nitroprusside in relaxing rat isolated aorta.

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21 January 2018

Inhibition of cyclic strain-induced endothelin-1 secretion by tetramethylpyrazine

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21 January 2018

Tetramethylpyrazine downregulates angiotensin II-induced endothelin-1 gene expression in vascular endothelial cells

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21 January 2018

Effects of tetramethylpyrazine on nitric oxide/cGMP signaling after cerebral vasospasm in rabbits

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21 January 2018

Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease

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21 January 2018

The effect of tetramethylpyrazine on hydrogen peroxide-induced oxidative damage in human umbilical vein endothelial cells

1 reference

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21 January 2018

Tetramethylpyrazine inhibits angiotensin II-increased NAD(P)H oxidase activity and subsequent proliferation in rat aortic smooth muscle cells

1 reference

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21 January 2018

Ligustrazine inhibits B16F10 melanoma metastasis and suppresses angiogenesis induced by Vascular Endothelial Growth Factor.

1 reference

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21 January 2018

Tetramethylpyrazine-eluting stents prevented in-stent restenosis in a porcine model.

1 reference

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21 January 2018

Tetramethylpyrazine attenuates atherosclerosis development and protects endothelial cells from ox-LDL.

1 reference

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21 January 2018

Tetramethylpyrazine as potassium channel opener to lower calcium influx into cultured aortic smooth muscle cells

1 reference

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21 January 2018

Effect of tetramethyl pyrazine on L-type calcium channel in rat ventricular myocytes

1 reference

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21 January 2018

Tetramethylpyrazine suppresses interleukin-8 expression in LPS-stimulated human umbilical vein endothelial cell by blocking ERK, p38 and nulear factor-kappaB signaling pathways.

1 reference

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21 January 2018

The protective effects of ligustrazine on ischemia-reperfusion and DPPH free radical-induced myocardial injury in isolated rat hearts

1 reference

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21 January 2018

Angiogenic effects of the extracts from Chinese herbs: Angelica and Chuanxiong.

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21 January 2018

Effects of tetramethylpyrazine on fibrosis of atrial tissue and atrial fibrillation in a canine model of congestive heart failure induced by ventricular tachypacing

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21 January 2018

Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the Definition and Classification of cardiomyopathies.

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21 January 2018

Ginsenoside-Rb1 and tetramethylpyrazine phosphate act synergistically to prevent dilated cardiomyopathy in cTnTR141W transgenic mice.

1 reference

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21 January 2018

Tetramethylpyrazine inhibits angiotensin II-induced cardiomyocyte hypertrophy and tumor necrosis factor-α secretion through an NF-κB-dependent mechanism

1 reference

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21 January 2018

[Effect of danshen chuanxiongqin injection on the myocardial damage of unstable angina patients undergoing percutaneous coronary intervention].

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28 November 2018

Determination of plasma protein binding rate of tetramethylpyrazine phosphate by ultrafiltration

1 reference

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28 November 2018

Protective effects of tetramethylpyrazine on rat myocardial cells infected by Coxsackie virus B3 and its signal transduction mechanism

1 reference

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28 November 2018

Effect of tetramethylpyrazine on platelet activation and vascular endothelial function in patients with acute coronary syndrome undergoing percutaneous coronary intervention

1 reference

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28 November 2018

Protective effect of tetramethylpyrazine and L-arginine on rats with acute myocardial infarction

1 reference

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28 November 2018

Ligustrazine and Salvia miltiorrhiza injection solution in complementary therapy of pregnancy-induced hypertension: clinical analysis of 60 cases

1 reference

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28 November 2018

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28 November 2018

[The pharmacokinetics and disposition of tetramethylpyrazine phosphate in dogs and rats]

1 reference

https://pubmed.ncbi.nlm.nih.gov/27314011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effect of ligustrazine against myocardial ischaemia reperfusion in rats: the role of endothelial nitric oxide synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/27314011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of ligustrazine on L-type calcium current, calcium transient and contractility in rabbit ventricular myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/27314011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ligustrazine improves atherosclerosis in rat via attenuation of oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/27314011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tetramethylpyrazine induces heme oxygenase-1 expression and attenuates myocardial ischemia/reperfusion injury in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/27314011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Clinical study on ligustrazine in treating myocardial ischemia and reperfusion injury]

1 reference

https://pubmed.ncbi.nlm.nih.gov/27314011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms involved in the antiplatelet activity of tetramethylpyrazine in human platelets

1 reference

https://pubmed.ncbi.nlm.nih.gov/27314011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effects of ligustrazine on TNF-α-induced endothelial dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/27314011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of antioxidant and immunity function of tetramethylpyrazine phosphate tablets in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/27314011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Study on metabolism of tetramethylpyrazine in system of rat liver microsomes]

1 reference

https://pubmed.ncbi.nlm.nih.gov/27314011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Investigation of metabolic kinetics and reaction phenotyping of ligustrazin by using liver microsomes and recombinant human enzymes]

1 reference

https://pubmed.ncbi.nlm.nih.gov/27314011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tetramethylpyrazine, a calcium antagonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/27314011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The antiplatelet activity of tetramethylpyrazine is mediated through activation of NO synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/27314011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[The pharmacological effect of ligustrazine on human platelets]

1 reference

https://pubmed.ncbi.nlm.nih.gov/27314011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The protective mechanism of ligustrazine against renal ischemia/reperfusion injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/27314011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of tetramethylpyrazine on the incidence of arrhythmias and the release of PGI2 and TXA2 in the ischemic rat heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/27314011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1155/2016/2430329

2 references

Consolidated OpenCitations Corpus – April 2017

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27314011%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27314011%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

PubMed publication ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27314011%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

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