Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance (Q26776393)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26660431%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

title

Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26660431%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

0 references

1 reference

acute myeloid leukemia

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author

Brian Huntly

series ordinal

3

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2 March 2020

author name string

David Grimwade

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26660431%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Adam Ivey

series ordinal

2

1 reference

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2 March 2020

language of work or name

English

0 references

publication date

10 December 2015

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2 March 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26660431%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

volume

127

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2 March 2020

issue

1

1 reference

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2 March 2020

page(s)

29-41

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Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions

2 March 2020

cites work

1 reference

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The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers

7 April 2017

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Recurring mutations found by sequencing an acute myeloid leukemia genome

7 April 2017

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Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia

7 April 2017

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AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation

7 April 2017

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Defining minimal residual disease in acute myeloid leukemia: which platforms are ready for "prime time"?

7 April 2017

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Cohesin mutations in myeloid malignancies: underlying mechanisms

7 April 2017

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FLT3 mutations in acute myeloid leukemia: what is the best approach in 2013?

7 April 2017

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Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis

7 April 2017

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Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

7 April 2017

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DNMT3A Mutations in Acute Myeloid Leukemia

7 April 2017

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Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype

7 April 2017

1 reference

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Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia

7 April 2017

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Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts

7 April 2017

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TET2 mutation is an unfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogenetics

7 April 2017

1 reference

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The prognostic significance of IDH2 mutations in AML depends on the location of the mutation

7 April 2017

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RUNX1 mutations in acute myeloid leukemia: results from a comprehensive genetic and clinical analysis from the AML study group

7 April 2017

1 reference

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Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis

7 April 2017

1 reference

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WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation

7 April 2017

1 reference

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DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia

7 April 2017

1 reference

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Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence

7 April 2017

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7 April 2017

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7 April 2017

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Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia

7 April 2017

1 reference

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Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia

7 April 2017

1 reference

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The origin and evolution of mutations in acute myeloid leukemia

7 April 2017

1 reference

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Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

7 April 2017

1 reference

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Frequent pathway mutations of splicing machinery in myelodysplasia

7 April 2017

1 reference

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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

7 April 2017

1 reference

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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

7 April 2017

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Epigenetics and approaches to targeted epigenetic therapy in acute myeloid leukemia

7 April 2017

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Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation

28 September 2017

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Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms

28 September 2017

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Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia

28 September 2017

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Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo

28 September 2017

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SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition

28 September 2017

1 reference

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Simpson's Paradox and the Impact of Different DNMT3A Mutations on Outcome in Younger Adults With Acute Myeloid Leukemia.

28 September 2017

1 reference

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Downregulation of the Wnt inhibitor CXXC5 predicts a better prognosis in acute myeloid leukemia

28 September 2017

1 reference

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Dasatinib in high-risk core binding factor acute myeloid leukemia in first complete remission: a French Acute Myeloid Leukemia Intergroup trial.

28 September 2017

1 reference

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Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia

28 September 2017

1 reference

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Acute myeloid leukemia ontogeny is defined by distinct somatic mutations

28 September 2017

1 reference

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Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia.

28 September 2017

1 reference

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Mutational spectrum of myeloid malignancies with inv(3)/t(3;3) reveals a predominant involvement of RAS/RTK signaling pathways

28 September 2017

1 reference

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Targeting FLT3 to treat leukemia

28 September 2017

1 reference

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Genetic alterations of the cohesin complex genes in myeloid malignancies.

28 September 2017

1 reference

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Frequent ASXL2 mutations in acute myeloid leukemia patients with t(8;21)/RUNX1-RUNX1T1 chromosomal translocations.

28 September 2017

1 reference

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Requirement for CDK6 in MLL-rearranged acute myeloid leukemia

28 September 2017

1 reference

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Expression profiling of leukemia patients: key lessons and future directions

28 September 2017

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Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission

28 September 2017

1 reference

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Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

28 September 2017

1 reference

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New agents: great expectations not realized

28 September 2017

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UKALLXII/ECOG2993: addition of imatinib to a standard treatment regimen enhances long-term outcomes in Philadelphia positive acute lymphoblastic leukemia

28 September 2017

1 reference

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Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemia

28 September 2017

1 reference

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The genetic basis of myelodysplasia and its clinical relevance

28 September 2017

1 reference

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Clinical and biological implications of driver mutations in myelodysplastic syndromes

28 September 2017

1 reference

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Retinoic acid and arsenic trioxide for acute promyelocytic leukemia

28 September 2017

1 reference

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The MLL recombinome of acute leukemias in 2013.

28 September 2017

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An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia

28 September 2017

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The European LeukemiaNet AML Working Party consensus statement on allogeneic HSCT for patients with AML in remission: an integrated-risk adapted approach

28 September 2017

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Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia.

28 September 2017

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Molecular markers in acute myeloid leukaemia

28 September 2017

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GATA2 zinc finger 1 mutations associated with biallelic CEBPA mutations define a unique genetic entity of acute myeloid leukemia

28 September 2017

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Clonal architecture of secondary acute myeloid leukemia

28 September 2017

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RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis

28 September 2017

1 reference

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Diagnostic and prognostic value of cytogenetics in acute myeloid leukemia

28 September 2017

1 reference

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MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.

28 September 2017

1 reference

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Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.

28 September 2017

1 reference

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Independent prognostic variables in acute myeloid leukaemia

28 September 2017

1 reference

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Hematopoietic stem cell expansion precedes the generation of committed myeloid leukemia-initiating cells in C/EBPalpha mutant AML.

28 September 2017

1 reference

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Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome

28 September 2017

1 reference

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Advances in molecular genetics and treatment of core-binding factor acute myeloid leukemia

28 September 2017

1 reference

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Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification?

28 September 2017

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Genetics of myeloid leukemias

28 September 2017

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Characterization of acute promyelocytic leukemia cases lacking the classic t(15;17): results of the European Working Party. Groupe Français de Cytogénétique Hématologique, Groupe de Français d'Hematologie Cellulaire, UK Cancer Cytogenetics [...]

28 September 2017

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Identificaton of a translocation with quinacrine fluorescence in a patient with acute leukemia.

28 September 2017

1 reference

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Arsenic trioxide and all-trans retinoic acid treatment for acute promyelocytic leukaemia in all risk groups (AML17): results of a randomised, controlled, phase 3 trial

28 September 2017

1 reference

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A powerful molecular synergy between mutant Nucleophosmin and Flt3-ITD drives acute myeloid leukemia in mice

31 May 2018

1 reference

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Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice

31 May 2018

1 reference

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Mass Cytometric Functional Profiling of Acute Myeloid Leukemia Defines Cell-Cycle and Immunophenotypic Properties That Correlate with Known Responses to Therapy

31 May 2018

1 reference

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Arsenic trioxide and all-trans retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in NPM1-mutated AML cells.

28 November 2018

1 reference

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Mutations in the cohesin complex in acute myeloid leukemia: clinical and prognostic implications

28 November 2018

1 reference

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Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4705608

Monitoring of residual disease by next-generation deep-sequencing of RUNX1 mutations can identify acute myeloid leukemia patients with resistant disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4705608

Integration of cytogenetic and molecular alterations in risk stratification of 318 patients with de novo non-M3 acute myeloid leukemia.

28 November 2018

1 reference

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Identification of patients with acute myeloblastic leukemia who benefit from the addition of gemtuzumab ozogamicin: results of the MRC AML15 trial.

28 November 2018

1 reference

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Prognostic significance of CEBPA mutations in a large cohort of younger adult patients with acute myeloid leukemia: impact of double CEBPA mutations and the interaction with FLT3 and NPM1 mutations.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4705608

Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4705608

AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4705608

Novel TET2 mutations associated with UPD4q24 in myelodysplastic syndrome.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4705608

The favorable impact of CEBPA mutations in patients with acute myeloid leukemia is only observed in the absence of associated cytogenetic abnormalities and FLT3 internal duplication.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4705608

Modeling of C/EBPα Mutant Acute Myeloid Leukemia Reveals a Common Expression Signature of Committed Myeloid Leukemia-Initiating Cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4705608

Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4705608

Fusion of the homeobox gene HLXB9 and the ETV6 gene in infant acute myeloid leukemias with the t(7;12)(q36;p13).

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4705608

TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome

28 November 2018

1 reference

12 December 2020

Association between acquired uniparental disomy and homozygous gene mutation in acute myeloid leukemias

1 reference

12 December 2020

Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: further evidence for CEBPA double mutant AML as a distinctive disease entity

1 reference

12 December 2020

15/17 translocation, a consistent chromosomal change in acute promyelocytic leukaemia

1 reference

12 December 2020

RUNX1 mutations are frequent in de novo AML with noncomplex karyotype and confer an unfavorable prognosis

1 reference

12 December 2020

Relationship between FLT3 mutation status, biologic characteristics, and response to targeted therapy in acute promyelocytic leukemia

1 reference

12 December 2020

FLT3 tyrosine kinase domain mutations are biologically distinct from and have a significantly more favorable prognosis than FLT3 internal tandem duplications in patients with acute myeloid leukemia

1 reference

12 December 2020

Differential prognosis impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia

1 reference

12 December 2020

Retinoic acid and arsenic trioxide trigger degradation of mutated NPM1, resulting in apoptosis of AML cells

1 reference

12 December 2020

Monosomal karyotype in acute myeloid leukemia: a better indicator of poor prognosis than a complex karyotype

1 reference

12 December 2020

A panoramic view of acute myeloid leukemia

1 reference

12 December 2020

10.1182/BLOOD-2015-07-604496

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26660431%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26660431%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

2 references