The Insulin/IGF System in Colorectal Cancer Development and Resistance to Therapy (Q26777125)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26528439%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Elena Tirrò

2

1 reference

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6 June 2020

Michele Massimino

4

1 reference

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6 June 2020

Stefania Stella

5

1 reference

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6 June 2020

author name string

Maria Stella Pennisi

3

1 reference

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6 June 2020

Chiara Romano

6

1 reference

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6 June 2020

Livia Manzella

7

1 reference

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6 June 2020

language of work or name

English

0 references

publication date

2015

0 references

published in

Frontiers in Oncology

2 references

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6 June 2020

volume

5

1 reference

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6 June 2020

page(s)

230

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26528439%20AND%20SRC:MED&resulttype=core&format=json

Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer

6 June 2020

cites work

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7 April 2017

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Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab

7 April 2017

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A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer

7 April 2017

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Cellular actions of the insulin-like growth factor binding proteins

7 April 2017

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A prospective study of plasma insulin-like growth factor-1 and binding protein-3 and risk of colorectal neoplasia in women

7 April 2017

1 reference

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The insulin receptor substrate 1 (IRS1) in intestinal epithelial differentiation and in colorectal cancer

7 April 2017

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Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis

7 April 2017

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A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations

7 April 2017

1 reference

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Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer

7 April 2017

1 reference

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Knockdown of type I insulin-like growth factor receptor inhibits human colorectal cancer cell growth and downstream PI3K/Akt, WNT/β-catenin signal pathways

7 April 2017

1 reference

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Association of circulating insulin-like growth factor 1 and insulin-like growth factor binding protein 3 with the risk of ovarian cancer: A systematic review and meta-analysis

28 September 2017

1 reference

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The Role of the Insulin/IGF System in Cancer: Lessons Learned from Clinical Trials and the Energy Balance-Cancer Link

28 September 2017

1 reference

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The role of the insulin-like growth factor-1 system in breast cancer

28 September 2017

1 reference

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MiR-143 and MiR-145 regulate IGF1R to suppress cell proliferation in colorectal cancer

28 September 2017

1 reference

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Resistance to anti-EGFR therapy in colorectal cancer: from heterogeneity to convergent evolution

28 September 2017

1 reference

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Detection of phosphorylated insulin receptor in colorectal adenoma and adenocarcinoma: implications for prognosis and clinical outcome

28 September 2017

1 reference

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Randomized phase Ib/II trial of rilotumumab or ganitumab with panitumumab versus panitumumab alone in patients with wild-type KRAS metastatic colorectal cancer

28 September 2017

1 reference

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Insulin receptor isoform switching in intestinal stem cells, progenitors, differentiated lineages and tumors: evidence that IR-B limits proliferation

28 September 2017

1 reference

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Novel insulin receptor substrate 1 and 2 variants in breast and colorectal cancer

28 September 2017

1 reference

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IRS2 is a candidate driver oncogene on 13q34 in colorectal cancer.

28 September 2017

1 reference

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Inhibition of IGF-IR increases chemosensitivity in human colorectal cancer cells through MRP-2 promoter suppression

28 September 2017

1 reference

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Insulin-like growth factor: current concepts and new developments in cancer therapy

28 September 2017

1 reference

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Signalling by insulin and IGF receptors: supporting acts and new players

28 September 2017

1 reference

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Germline polymorphisms in genes involved in the IGF1 pathway predict efficacy of cetuximab in wild-type KRAS mCRC patients

28 September 2017

1 reference

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Randomized, phase II study of the insulin-like growth factor-1 receptor inhibitor IMC-A12, with or without cetuximab, in patients with cetuximab- or panitumumab-refractory metastatic colorectal cancer

28 September 2017

1 reference

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Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease.

28 September 2017

1 reference

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Novel mechanism of IGF-binding protein-3 action on prostate cancer cells: inhibition of proliferation, adhesion, and motility

28 September 2017

1 reference

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Mechanism of growth inhibition by MicroRNA 145: the role of the IGF-I receptor signaling pathway

28 September 2017

1 reference

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Chemoresistant colorectal cancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition

28 September 2017

1 reference

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Insulin, the insulin-like growth factor axis, and mortality in patients with nonmetastatic colorectal cancer

28 September 2017

1 reference

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Acquired resistance to EGFR tyrosine kinase inhibitors in cancer cells is mediated by loss of IGF-binding proteins

28 September 2017

1 reference

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The p53-family members p63 and p73 inhibit insulin-like growth factor-I receptor gene expression in colon cancer cells

28 September 2017

1 reference

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28 September 2017

1 reference

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Insulin-like growth factor 1 receptor enhances invasion and induces resistance to apoptosis of colon cancer cells through the Akt/Bcl-x(L) pathway.

28 September 2017

1 reference

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Distinct and overlapping functions of insulin and IGF-I receptors

28 September 2017

1 reference

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Insulin, insulin-like growth factors and colon cancer: a review of the evidence

28 September 2017

1 reference

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Possible mechanisms relating diet and risk of colon cancer

28 September 2017

1 reference

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Elevated serum insulin-like growth factor (IGF)-II and IGF binding protein-2 in patients with colorectal cancer

28 September 2017

1 reference

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Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells.

28 September 2017

1 reference

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Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3.

28 September 2017

1 reference

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Epidemiology of colorectal cancer revisited: are serum triglycerides and/or plasma glucose associated with risk?

28 September 2017

1 reference

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Colorectal cancer: the natural history of disseminated disease - a review

28 September 2017

1 reference

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Functionally distinct insulin receptors generated by tissue-specific alternative splicing

28 September 2017

1 reference

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Structure and function of the mannose 6-phosphate/insulinlike growth factor II receptors

28 September 2017

1 reference

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Heterogeneity of receptor function in colon carcinoma cells determined by cross-talk between type I insulin-like growth factor receptor and epidermal growth factor receptor

28 September 2017

1 reference

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Intracellular presence of insulin and its phosphorylated receptor in non-small cell lung cancer.

31 May 2018

1 reference

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Serum C-peptide, insulin-like growth factor (IGF)-I, IGF-binding proteins, and colorectal cancer risk in women.

21 January 2018

1 reference

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Plasma insulin-like growth factor-binding protein-2 levels as diagnostic and prognostic biomarker of colorectal cancer.

21 January 2018

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The role of insulin-like growth factor 1 and its receptor in the formation and development of colorectal carcinoma

21 January 2018

1 reference

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Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study

21 January 2018

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Insulin-like growth factor 1 expression correlates with clinical outcome in K-RAS wild type colorectal cancer patients treated with cetuximab and irinotecan.

21 January 2018

1 reference

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MMP7 and activation of IGF-1R: a new insight into anti-EGFR therapeutic resistance in metastatic colorectal cancer.

21 January 2018

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Associations among IRS1, IRS2, IGF1, and IGFBP3 genetic polymorphisms and colorectal cancer.

21 January 2018

1 reference

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Serum insulin-like growth factor-I and breast cancer.

28 November 2018

1 reference

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IGF-I and IGF-II in relation to colorectal cancer

28 November 2018

1 reference

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Blockade of the insulin-like growth-factor-I receptor inhibits growth of human colorectal cancer cells: evidence of a functional IGF-II-mediated autocrine loop

28 November 2018

1 reference

12 December 2020

Functional responses and in vivo anti-tumour activity of h7C10: a humanised monoclonal antibody with neutralising activity against the insulin-like growth factor-1 (IGF-1) receptor and insulin/IGF-1 hybrid receptors

1 reference

12 December 2020

Type 2 diabetes mellitus as risk factor for colorectal cancer

1 reference

12 December 2020

Insulin–Insulin-Like Growth Factor Axis and Colon Cancer

1 reference

12 December 2020

Plasma insulin-like growth factor-I, insulin-like growth factor-binding proteins, and prostate cancer risk: a prospective study

1 reference

12 December 2020

Insulin therapy and colorectal cancer risk among type 2 diabetes mellitus patients

1 reference

12 December 2020

The role of insulin receptors and IGF-I receptors in cancer and other diseases

1 reference

12 December 2020

Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: evidence for a second mechanism of IGF-I signaling

1 reference

12 December 2020

Colorectal cancer: the modern treatment of disseminated disease - a review

1 reference

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7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.3389/FONC.2015.00230

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26528439%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26528439%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26528439%20AND%20SRC:MED&resulttype=core&format=json