Recoupling the cardiac nitric oxide synthases: tetrahydrobiopterin synthesis and recycling (Q26822833)

main subject

heterocyclic compound

1 reference

17 September 2019

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28 September 2019

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4 November 2019

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18 November 2019

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Matthew S. Alkaitis

1

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Mark J. Crabtree

series ordinal

2

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language of work or name

1 reference

September 2012

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Current heart failure reports

1 September 2012

4 references

17 September 2019

28 September 2019

4 November 2019

18 November 2019

5 references

17 September 2019

28 September 2019

4 November 2019

18 November 2019

9

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issue

3

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page(s)

200-10

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Uncoupled cardiac nitric oxide synthase mediates diastolic dysfunction

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GTP cyclohydrolase I phosphorylation and interaction with GTP cyclohydrolase feedback regulatory protein provide novel regulation of endothelial tetrahydrobiopterin and nitric oxide

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28 September 2017

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Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression

28 September 2017

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GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function

28 September 2017

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Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin: efficacy of recoupling nitric oxide synthase as a therapeutic strategy

28 September 2017

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28 September 2017

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Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS.

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Endogenous methylarginines modulate superoxide as well as nitric oxide generation from neuronal nitric-oxide synthase: differences in the effects of monomethyl- and dimethylarginines in the presence and absence of tetrahydrobiopterin

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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31 May 2018

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Macrophage oxidation of L-arginine to nitric oxide, nitrite, and nitrate. Tetrahydrobiopterin is required as a cofactor

31 May 2018

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N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine

31 May 2018

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Generation of superoxide by purified brain nitric oxide synthase

31 May 2018

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Endothelium-specific GTP cyclohydrolase I overexpression attenuates blood pressure progression in salt-sensitive low-renin hypertension

31 May 2018

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A tetrahydrobiopterin radical forms and then becomes reduced during Nomega-hydroxyarginine oxidation by nitric-oxide synthase

21 January 2018

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Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo: insights from transgenic mice with endothelial-targeted GTP cyclohydrolase 1 and eNOS overexpression

21 January 2018

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Altered plasma versus vascular biopterins in human atherosclerosis reveal relationships between endothelial nitric oxide synthase coupling, endothelial function, and inflammation

21 January 2018

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21 January 2018

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Reaction of tetrahydrobiopterin with superoxide: EPR-kinetic analysis and characterization of the pteridine radical

21 January 2018

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21 January 2018

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Effects of neuronal nitric oxide synthase on human coronary artery diameter and blood flow in vivo.

21 January 2018

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Endogenous nitric oxide mechanisms mediate the stretch dependence of Ca2+ release in cardiomyocytes

21 January 2018

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Spontaneous myocardial infarction in mice lacking all nitric oxide synthase isoforms

21 January 2018

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Supplementation with tetrahydrobiopterin prevents the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress

21 January 2018

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Role of tetrahydrobiopterin in adrenocorticotropic hormone-induced hypertension in the rat.

21 January 2018

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Novel cardioprotective effects of tetrahydrobiopterin after anoxia and reoxygenation: Identifying cellular targets for pharmacologic manipulation

21 January 2018

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Beneficial effect of tetrahydrobiopterin on ischemia-reperfusion injury in isolated perfused rat hearts

21 January 2018

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Regulation of eNOS-derived superoxide by endogenous methylarginines

21 January 2018

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Mechanism of 4-HNE mediated inhibition of hDDAH-1: implications in no regulation.

21 January 2018

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Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis

21 January 2018

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L-arginine supplementation in peripheral arterial disease: no benefit and possible harm

21 January 2018

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L-arginine therapy in acute myocardial infarction: the Vascular Interaction With Age in Myocardial Infarction (VINTAGE MI) randomized clinical trial

21 January 2018

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Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertensive individuals

21 January 2018

1 reference

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Chronic treatment with tetrahydrobiopterin reverses endothelial dysfunction and oxidative stress in hypercholesterolaemia

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11897-012-0097-5

Tetrahydrobiopterin: a novel antihypertensive therapy

21 January 2018

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Efficacy of sapropterin dihydrochloride (tetrahydrobiopterin, 6R-BH4) for reduction of phenylalanine concentration in patients with phenylketonuria: a phase III randomised placebo-controlled study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11897-012-0097-5

Formation of a Pterin Radical in the Reaction of the Heme Domain of Inducible Nitric Oxide Synthase with Oxygen†

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11897-012-0097-5

Induction of tetrahydrobiopterin synthesis in rat cardiac myocytes: impact on cytokine-induced NO generation

21 January 2018

1 reference

12 December 2020

Basal release of nitric oxide augments the Frank-Starling response in the isolated heart

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12 December 2020

Superoxide generation from endothelial nitric-oxide synthase. A Ca2+/calmodulin-dependent and tetrahydrobiopterin regulatory process

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12 December 2020

5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling

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12 December 2020

Evidence for the pathophysiological role of endogenous methylarginines in regulation of endothelial NO production and vascular function

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12 December 2020

Oral administration of tetrahydrobiopterin slows the progression of atherosclerosis in apolipoprotein E-knockout mice

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12 December 2020

Macrophage nitric oxide synthase subunits. Purification, characterization, and role of prosthetic groups and substrate in regulating their association into a dimeric enzyme

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12 December 2020

Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes. Characterization and regulation of iNOS expression and detection of iNOS activity in single cardiac myocytes in vitro

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12 December 2020

Nitric oxide-dependent parasympathetic signaling is due to activation of constitutive endothelial (type III) nitric oxide synthase in cardiac myocytes

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12 December 2020

Myocardial redox state predicts in-hospital clinical outcome after cardiac surgery effects of short-term pre-operative statin treatment

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12 December 2020

Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus

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12 December 2020

Downregulation of Endocardial Nitric Oxide Synthase Expression and Nitric Oxide Production in Atrial Fibrillation

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12 December 2020

10.1007/S11897-012-0097-5

Identifiers

DOI

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Dimensions Publication ID

1049529611

0 references

Fatcat ID

release_wpjvcffd4bbxhal5x2vt5pn7se

0 references

1 reference

1 reference

PubMed publication ID

22711313

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