Bedaquiline for the treatment of multidrug-resistant tuberculosis: great promise or disappointment? (Q26824413)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26137207%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

review article

1 reference

title

Bedaquiline for the treatment of multidrug-resistant tuberculosis: great promise or disappointment? (English)

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26137207%20AND%20SRC:MED&resulttype=core&format=json

multidrug-resistant tuberculosis

18 February 2020

main subject

multiple drug resistance

0 references

tuberculosis

0 references

1 reference

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26137207%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

author name string

S. K. Field

series ordinal

1

1 reference

language of work or name

1 reference

1 July 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26137207%20AND%20SRC:MED&resulttype=core&format=json

Therapeutic advances in chronic disease

18 February 2020

published in

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26137207%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

volume

6

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26137207%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

issue

4

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26137207%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

page(s)

170-184

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26137207%20AND%20SRC:MED&resulttype=core&format=json

Approval of a Tuberculosis Drug Based on a Paradoxical Surrogate Measure

18 February 2020

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7 April 2017

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The diarylquinoline TMC207 for multidrug-resistant tuberculosis

7 April 2017

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Treatment of multidrug-resistant tuberculosis

7 April 2017

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7 April 2017

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Rapid evaluation in whole blood culture of regimens for XDR-TB containing PNU-100480 (sutezolid), TMC207, PA-824, SQ109, and pyrazinamide

7 April 2017

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Probing the interaction of the diarylquinoline TMC207 with its target mycobacterial ATP synthase

7 April 2017

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Sterilizing activity of second-line regimens containing TMC207 in a murine model of tuberculosis

7 April 2017

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Diarylquinolines target subunit c of mycobacterial ATP synthase

7 April 2017

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Acquired resistance of Mycobacterium tuberculosis to bedaquiline

7 April 2017

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Efflux inhibition with verapamil potentiates bedaquiline in Mycobacterium tuberculosis

7 April 2017

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A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis

7 April 2017

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Preliminary Results of Bedaquiline as Salvage Therapy for Patients With Nontuberculous Mycobacterial Lung Disease

7 April 2017

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Rifampicin and rifapentine significantly reduce concentrations of bedaquiline, a new anti-TB drug

28 September 2017

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Verapamil increases the bactericidal activity of bedaquiline against Mycobacterium tuberculosis in a mouse model

28 September 2017

1 reference

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Multidrug-resistant tuberculosis and culture conversion with bedaquiline.

28 September 2017

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FDA approval of bedaquiline--the benefit-risk balance for drug-resistant tuberculosis

28 September 2017

1 reference

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Impact of lopinavir-ritonavir or nevirapine on bedaquiline exposures and potential implications for patients with tuberculosis-HIV coinfection

28 September 2017

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Population pharmacokinetics of bedaquiline (TMC207), a novel antituberculosis drug.

28 September 2017

1 reference

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Cross-resistance between clofazimine and bedaquiline through upregulation of MmpL5 in Mycobacterium tuberculosis

28 September 2017

1 reference

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Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism.

28 September 2017

1 reference

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Verapamil, and its metabolite norverapamil, inhibit macrophage-induced, bacterial efflux pump-mediated tolerance to multiple anti-tubercular drugs

28 September 2017

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Bedaquiline metabolism: enzymes and novel metabolites

28 September 2017

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Novel regimens identified in mice for treatment of latent tuberculosis infection in contacts of patients with multidrug-resistant tuberculosis

28 September 2017

1 reference

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A review of tuberculosis: Focus on bedaquiline

28 September 2017

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Provisional CDC guidelines for the use and safety monitoring of bedaquiline fumarate (Sirturo) for the treatment of multidrug-resistant tuberculosis

28 September 2017

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Bedaquiline for the treatment of pulmonary, multidrug-resistant tuberculosis in adults

28 September 2017

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Model-based estimates of the effects of efavirenz on bedaquiline pharmacokinetics and suggested dose adjustments for patients coinfected with HIV and tuberculosis

28 September 2017

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Randomized dose-ranging study of the 14-day early bactericidal activity of bedaquiline (TMC207) in patients with sputum microscopy smear-positive pulmonary tuberculosis

28 September 2017

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28 September 2017

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28 September 2017

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Sterilizing activities of novel combinations lacking first- and second-line drugs in a murine model of tuberculosis

28 September 2017

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Randomized pilot trial of eight weeks of bedaquiline (TMC207) treatment for multidrug-resistant tuberculosis: long-term outcome, tolerability, and effect on emergence of drug resistance.

28 September 2017

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Pharmacokinetics and pharmacodynamics of TMC207 and its N-desmethyl metabolite in a murine model of tuberculosis

28 September 2017

1 reference

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Safety, tolerability, and pharmacokinetic interactions of the antituberculous agent TMC207 (bedaquiline) with efavirenz in healthy volunteers: AIDS Clinical Trials Group Study A5267.

28 September 2017

1 reference

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Sterilizing activity of novel TMC207- and PA-824-containing regimens in a murine model of tuberculosis

28 September 2017

1 reference

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Short-course chemotherapy with TMC207 and rifapentine in a murine model of latent tuberculosis infection

28 September 2017

1 reference

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Activities of TMC207, rifampin, and pyrazinamide against Mycobacterium tuberculosis infection in guinea pigs

28 September 2017

1 reference

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Bactericidal activity of the diarylquinoline TMC207 against Mycobacterium tuberculosis outside and within cells

28 September 2017

1 reference

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Bactericidal potencies of new regimens are not predictive of their sterilizing potencies in a murine model of tuberculosis

28 September 2017

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28 September 2017

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ATP synthase inhibition of Mycobacterium avium is not bactericidal

28 September 2017

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Selectivity of TMC207 towards mycobacterial ATP synthase compared with that towards the eukaryotic homologue

28 September 2017

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A once-weekly R207910-containing regimen exceeds activity of the standard daily regimen in murine tuberculosis

28 September 2017

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28 September 2017

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Early bactericidal activity and pharmacokinetics of the diarylquinoline TMC207 in treatment of pulmonary tuberculosis

28 September 2017

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In vitro antimycobacterial spectrum of a diarylquinoline ATP synthase inhibitor

28 September 2017

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28 September 2017

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Combinations of R207910 with drugs used to treat multidrug-resistant tuberculosis have the potential to shorten treatment duration

28 September 2017

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In vitro and in vivo activities of rifampin, streptomycin, amikacin, moxifloxacin, R207910, linezolid, and PA-824 against Mycobacterium ulcerans.

28 September 2017

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Bactericidal activities of R207910 and other newer antimicrobial agents against Mycobacterium leprae in mice

28 September 2017

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Noncompliance with directly observed therapy for tuberculosis. Epidemiology and effect on the outcome of treatment

28 September 2017

1 reference

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Compassionate use of bedaquiline for the treatment of multidrug-resistant and extensively drug-resistant tuberculosis: interim analysis of a French cohort

28 September 2017

1 reference

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In vitro combination studies of benzothiazinone lead compound BTZ043 against Mycobacterium tuberculosis

31 May 2018

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New mutations in the mycobacterial ATP synthase: new insights into the binding of the diarylquinoline TMC207 to the ATP synthase C-ring structure

31 May 2018

1 reference

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Rates and mechanisms of resistance development in Mycobacterium tuberculosis to a novel diarylquinoline ATP synthase inhibitor

31 May 2018

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The diarylquinoline R207910 is bactericidal against Mycobacterium leprae in mice at low dose and administered intermittently

31 May 2018

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Genetic basis for natural and acquired resistance to the diarylquinoline R207910 in mycobacteria

31 May 2018

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Clinical Access Program for Bedaquiline for the treatment of drug-resistant tuberculosis

31 May 2018

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Sterilizing activity of R207910 (TMC207)-containing regimens in the murine model of tuberculosis.

21 January 2018

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https://api.crossref.org/works/10.1177%2F2040622315582325

Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F2040622315582325

In vivo evaluation of antibiotic activity against Mycobacterium abscessus

21 January 2018

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https://api.crossref.org/works/10.1177%2F2040622315582325

Clinical access to Bedaquiline Programme for the treatment of drug-resistant tuberculosis

21 January 2018

1 reference

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Cost of tuberculosis in the era of multidrug resistance: will it become unaffordable?

28 November 2018

1 reference

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Dose-ranging activity of the newly registered antituberculosis drug bedaquiline (TMC207)

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/26137207

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1177/2040622315582325

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26137207%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26137207%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

2 references