Separation of mAbs molecular variants by analytical hydrophobic interaction chromatography HPLC: overview and applications (Q26824543)

Mengisen S

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2

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Shameem M

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Ambrogelly A

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4

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language of work or name

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2014

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published in

Monoclonal Antibodies

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27 September 2019

20 November 2019

27 November 2019

13 December 2019

6

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issue

4

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page(s)

852-8

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Creative Commons Attribution-NonCommercial 3.0 Unported

copyright license

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27 September 2019

20 November 2019

27 November 2019

Fast identification of folded human protein domains expressed in E. coli suitable for structural analysis

13 December 2019

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1 reference

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Developability studies before initiation of process development: improving manufacturability of monoclonal antibodies

7 April 2017

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Chromatographic analysis of the acidic and basic species of recombinant monoclonal antibodies

28 September 2017

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Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars

28 September 2017

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Conformational stability and aggregation of therapeutic monoclonal antibodies studied with ANS and Thioflavin T binding

28 September 2017

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Classification and characterization of therapeutic antibody aggregates

28 September 2017

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Analytical methods for physicochemical characterization of antibody drug conjugates

28 September 2017

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Separation of oxidized variants of a monoclonal antibody by anion-exchange

28 September 2017

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Design of therapeutic proteins with enhanced stability.

28 September 2017

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Separation and characterization of an IgG2 antibody containing a cyclic imide in CDR1 of light chain by hydrophobic interaction chromatography and mass spectrometry

28 September 2017

1 reference

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Liquid chromatography of recombinant proteins and protein drugs

28 September 2017

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Natural expansion of the genetic code

28 September 2017

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Characterizing biological products and assessing comparability following manufacturing changes.

28 September 2017

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Structure-immunogenicity relationships of therapeutic proteins

28 September 2017

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Hydrophobic interaction chromatography of proteins.

28 September 2017

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Comparison of the in vitro and in vivo stability of a succinimide intermediate observed on a therapeutic IgG1 molecule

28 September 2017

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HIC resolution of an IgG1 with an oxidized Trp in a complementarity determining region.

31 May 2018

1 reference

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Separation of populations of antibody variants by fine tuning of hydrophobic-interaction chromatography operating conditions.

21 January 2018

1 reference

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O-fucosylation of an antibody light chain: characterization of a modification occurring on an IgG1 molecule

21 January 2018

1 reference

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Aspartate isomerization in the complementarity-determining regions of two closely related monoclonal antibodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.28693

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.28693

Impact of short range hydrophobic interactions and long range electrostatic forces on the aggregation kinetics of a monoclonal antibody and a dual-variable domain immunoglobulin at low and high concentrations.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.28693

Aggregation-prone motifs in human immunoglobulin G.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.28693

Structure-based engineering of a monoclonal antibody for improved solubility

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.28693

Heterogeneity of recombinant antibodies: linking structure to function

21 January 2018

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Effects of drug loading on the antitumor activity of a monoclonal antibody drug conjugate

28 November 2018

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12 December 2020

Microheterogeneity of a purified IgG1, due to asymmetric fab glycosylation

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12 December 2020

Single-step purification of F(ab')2 mu fragments of mouse monoclonal antibodies (immunoglobulins M) by hydrophobic interaction high-performance liquid chromatography using TSKgel ether-5PW

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12 December 2020

Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists

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12 December 2020

An adaptation of hydrophobic interaction chromatography for estimation of protein solubility optima

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12 December 2020

The effects of arginine on protein binding and elution in hydrophobic interaction and ion-exchange chromatography

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12 December 2020

Developability index: a rapid in silico tool for the screening of antibody aggregation propensity

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12 December 2020

Aggregation-resistant domain antibodies engineered with charged mutations near the edges of the complementarity-determining regions

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12 December 2020

Identifiers

DOI

10.4161/MABS.28693

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PubMed publication ID

24751784

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