Novel derivatives of polymyxins (Q26824934)

language of work or name

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June 2013

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Journal of Antimicrobial Chemotherapy

published in

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volume

68

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issue

6

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page(s)

1213-9

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Discovery research: the scientific challenge of finding new antibiotics

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Fourteen years in resistance

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Improving known classes of antibiotics: an optimistic approach for the future

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Dosing of colistin-back to basic PK/PD.

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Polymyxins and their novel derivatives

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Molecular basis of bacterial outer membrane permeability

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Nephrotoxicity of colistin: new insight into an old antibiotic

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Population pharmacokinetics of colistin methanesulfonate and formed colistin in critically ill patients from a multicenter study provide dosing suggestions for various categories of patients

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Increased substitution of phosphate groups in lipopolysaccharides and lipid A of the polymyxin-resistant pmrA mutants of Salmonella typhimurium: a 31P-NMR study

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Lipid A modification systems in gram-negative bacteria

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Ability of cecropin B to penetrate the enterobacterial outer membrane

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A pmrA constitutive mutant sensitizes Escherichia coli to deoxycholic acid

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PhoPQ-mediated regulation produces a more robust permeability barrier in the outer membrane of Salmonella enterica serovar typhimurium.

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Colistin resistance in Acinetobacter baumannii is mediated by complete loss of lipopolysaccharide production

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Impaired virulence and in vivo fitness of colistin-resistant Acinetobacter baumannii.

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Acinetobacter baumannii Resistant to Colistin With Impaired Virulence: A Case Report From France

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Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents

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Antimicrobial activity of the novel polymyxin derivative NAB739 tested against Gram-negative pathogens.

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Susceptibility of carbapenemase-producing strains of Klebsiella pneumoniae and Escherichia coli to the direct antibacterial activity of NAB739 and to the synergistic activity of NAB7061 with rifampicin and clarithromycin

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Novel polymyxin derivatives are effective in treating experimental Escherichia coli peritoneal infection in mice

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Novel polymyxin derivatives are less cytotoxic than polymyxin B to renal proximal tubular cells.

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The novel polymyxin derivative NAB739 is remarkably less cytotoxic than polymyxin B and colistin to human kidney proximal tubular cells

21 January 2018

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Structure–activity studies on novel polymyxin derivatives that carry only three positive charges

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Sensitization of Gram-negative bacteria to antibiotics and complement by a nontoxic oligopeptide

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Development of des-fatty acyl-polymyxin B decapeptide analogs with Pseudomonas aeruginosa-specific antimicrobial activity

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Antibacterial synergism of polymyxin B nonapeptide and hydrophobic antibiotics in experimental gram-negative infections in mice

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Purification, toxicity, and antiendotoxin activity of polymyxin B nonapeptide

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A novel polymyxin derivative that lacks the fatty acid tail and carries only three positive charges has strong synergism with agents excluded by the intact outer membrane

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Susceptibility of gram-negative bacteria to the synergistic bactericidal action of serum and polymyxin B nonapeptide

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In vitro activity of telavancin in combination with colistin versus Gram-negative bacterial pathogens

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New approaches in peptide antibiotics

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Update on antibacterial and antifungal drugs - can we master the resistance crisis?

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7 January 2021

Susceptibility of Klebsiella spp. to colistin and polymyxin B: results from the SENTRY Antimicrobial Surveillance Program (2006-2009)

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7 January 2021

N-terminal modifications of Polymyxin B nonapeptide and their effect on antibacterial activity

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7 January 2021

Antibiograms of multidrug-resistant clinical Acinetobacter baumannii: promising therapeutic options for treatment of infection with colistin-resistant strains

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7 January 2021

Pharmacokinetics of novel antimicrobial cationic peptides NAB 7061 and NAB 739 in rats following intravenous administration

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7 January 2021

pAM beta 1 resolvase has an atypical recombination site and requires a histone-like protein HU

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7 January 2021

Characterization of lipopolysaccharides of polymyxin-resistant and polymyxin-sensitive Klebsiella pneumoniae O3

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7 January 2021

Group of peptides that act synergistically with hydrophobic antibiotics against gram-negative enteric bacteria.

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7 January 2021

Molecular basis of bacterial outer membrane permeability revisited

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7 January 2021

Novel des-fatty acyl-polymyxin B derivatives with Pseudomonas aeruginosa-specific antimicrobial activity

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7 January 2021

Identifiers

DOI

10.1093/JAC/DKT039

0 references

PubMed publication ID

23412346

1 reference