Pathophysiology of microcirculatory dysfunction and the pathogenesis of septic shock (Q26851227)

19 July 2021

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24067428

microcirculation

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4

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Katia Donadello

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Katia Donadello

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3

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author name string

Daniel De Backer

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1

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Diego Orbegozo Cortes

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language of work or name

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1 January 2014

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23 March 2019

4 August 2019

19 July 2021

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23 March 2019

4 August 2019

19 July 2021

5

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issue

1

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page(s)

73-9

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Creative Commons Attribution-NonCommercial 3.0 Unported

copyright license

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Europe PubMed Central

23 March 2019

Europe PubMed Central

4 August 2019

Europe PubMed Central

on focus list of Wikimedia project

19 July 2021

ScienceSource

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cites work

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28 September 2017

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Effects of changes in arterial pressure on organ perfusion during septic shock

28 September 2017

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The role of renal hypoperfusion in development of renal microcirculatory dysfunction in endotoxemic rats.

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28 September 2017

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Assessments of skin and tongue microcirculation reveals major changes in porcine sepsis

28 September 2017

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Impaired microvascular perfusion in sepsis requires activated coagulation and P-selectin-mediated platelet adhesion in capillaries

28 September 2017

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Cutaneous ear lobe Pco₂ at 37°C to evaluate microperfusion in patients with septic shock

28 September 2017

1 reference

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Serum heparan sulfate levels are elevated in endotoxemia.

28 September 2017

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Recombinant activated protein C treatment improves tissue perfusion and oxygenation in septic patients measured by near-infrared spectroscopy

28 September 2017

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Increasing arterial blood pressure with norepinephrine does not improve microcirculatory blood flow: a prospective study

28 September 2017

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Link between coagulation abnormalities and microcirculatory dysfunction in critically ill patients

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916386

Mechanism of action of vitamin C in sepsis: ascorbate modulates redox signaling in endothelium

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916386

Septic impairment of capillary blood flow requires nicotinamide adenine dinucleotide phosphate oxidase but not nitric oxide synthase and is rapidly reversed by ascorbate through an endothelial nitric oxide synthase-dependent mechanism

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916386

Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis

28 September 2017

1 reference

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Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS.

28 September 2017

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Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease

28 September 2017

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Microvascular response to red blood cell transfusion in patients with severe sepsis

28 September 2017

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Erythropoietin improves skeletal muscle microcirculation and tissue bioenergetics in a mouse sepsis model

28 September 2017

1 reference

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Impairments in microvascular reactivity are related to organ failure in human sepsis

28 September 2017

1 reference

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Myocardial hypoxia-inducible HIF-1alpha, VEGF, and GLUT1 gene expression is associated with microvascular and ICAM-1 heterogeneity during endotoxemia

28 September 2017

1 reference

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Microcirculatory dysfunction in the brain precedes changes in evoked potentials in endotoxin-induced sepsis syndrome in rats

28 September 2017

1 reference

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Delayed ascorbate bolus protects against maldistribution of microvascular blood flow in septic rat skeletal muscle

28 September 2017

1 reference

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Red blood cell rheology in sepsis.

28 September 2017

1 reference

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Ascorbate prevents microvascular dysfunction in the skeletal muscle of the septic rat.

28 September 2017

1 reference

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TNF-alpha increases entry of macromolecules into luminal endothelial cell glycocalyx

28 September 2017

1 reference

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Capillaries and arterioles are electrically coupled in hamster cheek pouch

28 September 2017

1 reference

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Decreased capillary density in vivo in bowel mucosa of rats with normotensive sepsis.

28 September 2017

1 reference

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Skeletal muscle microvascular blood flow and oxygen transport in patients with severe sepsis

28 September 2017

1 reference

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Enoxaparin and fondaparinux attenuates endothelial damage in endotoxemic rats

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916386

Enoxaparin attenuates endothelial damage with less bleeding compared with unfractionated heparin in endotoxemic rats

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916386

Microvascular blood flow is altered in patients with sepsis

31 May 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

Microcirculatory alterations in patients with severe sepsis: impact of time of assessment and relationship with outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

Effects of fluids on microvascular perfusion in patients with severe sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

Hepatic platelet and leukocyte adherence during endotoxemia

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

Evaluation of sublingual and gut mucosal microcirculation in sepsis: a quantitative analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

Ascorbate inhibits reduced arteriolar conducted vasoconstriction in septic mouse cremaster muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

Sublingual microcirculatory changes during high-volume hemofiltration in hyperdynamic septic shock patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

Orthogonal polarization spectral imaging: a new method for study of the microcirculation

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

Sidestream Dark Field (SDF) imaging: a novel stroboscopic LED ring-based imaging modality for clinical assessment of the microcirculation.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

Quantitative assessment of the microcirculation in healthy volunteers and in patients with septic shock

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

Effect of decreased O2 supply on skeletal muscle oxygenation and O2 consumption during sepsis: role of heterogeneous capillary spacing and blood flow.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

Microvascular alterations in patients with acute severe heart failure and cardiogenic shock

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

Persistent low microcirculatory vessel density in nonsurvivors of sepsis in pediatric intensive care.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

Sublingual capnography: a clinical validation study

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

Sublingual capnometry tracks microcirculatory changes in septic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

Gastric capnometry with air-automated tonometry predicts outcome in critically ill patients

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

Persistent villi hypoperfusion explains intramucosal acidosis in sheep endotoxemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

Effect of treatment delay on disease severity and need for resuscitation in porcine fecal peritonitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

Microvascular dysfunction and skeletal muscle oxygenation assessed by phase-modulation near-infrared spectroscopy in patients with septic shock

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

Tumor necrosis factor-alpha inhibition protects against endotoxin-induced endothelial glycocalyx perturbation.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

Microvascular and capillary perfusion following glycocalyx degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

Both passive leg raising and intravascular volume expansion improve sublingual microcirculatory perfusion in severe sepsis and septic shock patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

Hydroxyethyl starch (130 kD), but not crystalloid volume support, improves microcirculation during normotensive endotoxemia

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

Dobutamine maintains intestinal villus blood flow during normotensive endotoxemia: an intravital microscopic study in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

Levosimendan is superior to milrinone and dobutamine in selectively increasing microvascular gastric mucosal oxygenation in dogs

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

Effects of vasopressin, norepinephrine, and L-arginine on intestinal microcirculation in endotoxemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

Restoring arterial pressure with norepinephrine improves muscle tissue oxygenation assessed by near-infrared spectroscopy in severely hypotensive septic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

Effects of nitroglycerin on sublingual microcirculatory blood flow in patients with severe sepsis/septic shock after a strict resuscitation protocol: a double-blind randomized placebo controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

Dose-dependent benefit of nitroglycerin on microcirculation of patients with severe heart failure.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

Sublingual microcirculatory effects of enalaprilat in an ovine model of septic shock

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

Tetrahydrobiopterin restores endothelial dysfunction induced by an oral glucose challenge in healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

Administration of tetrahydrobiopterin improves the microcirculation and outcome in an ovine model of septic shock.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

Activated protein C reduces tissue hypoxia, inflammation, and apoptosis in traumatized skeletal muscle during endotoxemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

Antithrombin effects on endotoxin-induced microcirculatory disorders are mediated mainly by its interaction with microvascular endothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FVIRU.26482

Failure of nitroglycerin (glyceryl trinitrate) to improve villi hypoperfusion in endotoxaemic shock in sheep.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916386

Endothelial glycocalyx damage during endotoxemia coincides with microcirculatory dysfunction and vascular oxidative stress

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916386

Lipopolysaccharide reduces intercellular coupling in vitro and arteriolar conducted response in vivo

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3916386

Heterogeneity of gut capillary transit times and impaired gut oxygen extraction in endotoxemic pigs

28 November 2018

1 reference

12 December 2020

Increased microvascular reactivity and improved mortality in septic mice lacking inducible nitric oxide synthase

1 reference

12 December 2020

Nitroglycerin in septic shock after intravascular volume resuscitation

1 reference

12 December 2020

Role of protein C in renal dysfunction after polymicrobial sepsis

1 reference

12 December 2020

Impaired microcirculation predicts poor outcome of patients with acute myocardial infarction complicated by cardiogenic shock

1 reference

12 December 2020

Changes in muscle tissue oxygenation during stagnant ischemia in septic patients

1 reference

12 December 2020

Renal arterial resistance in septic shock: effects of increasing mean arterial pressure with norepinephrine on the renal resistive index assessed with Doppler ultrasonography

1 reference

12 December 2020

Impact of leukocytes and platelets in mediating hepatocyte apoptosis in a rat model of systemic endotoxemia

1 reference

12 December 2020

Effect of a maldistribution of microvascular blood flow on capillary O(2) extraction in sepsis

1 reference

12 December 2020

The prognostic value of muscle StO2 in septic patients

1 reference

12 December 2020

DYNAMIC NEAR-INFRARED SPECTROSCOPY MEASUREMENTS IN PATIENTS WITH SEVERE SEPSIS

1 reference

12 December 2020

The influence of early hemodynamic optimization on biomarker patterns of severe sepsis and septic shock

1 reference

12 December 2020

Heterogeneity of oxygen delivery impairs oxygen extraction by peripheral tissues: theory

1 reference

12 December 2020

Endotoxin promotes adhesion of human erythrocytes to human vascular endothelial cells under conditions of flow

1 reference

12 December 2020

Endothelial cell glycocalyx modulates immobilization of leukocytes at the endothelial surface

1 reference

12 December 2020

Tetrahydrobiopterin Attenuates Microvascular Reperfusion Injury Following Murine Pancreas Transplantation

1 reference

12 December 2020

Muscle perfusion and oxygen consumption by near-infrared spectroscopy in septic-shock and non-septic-shock patients

1 reference

12 December 2020

The thrombin antagonist hirudin fails to inhibit endotoxin-induced leukocyte/endothelial cell interaction and microvascular perfusion failure

1 reference

12 December 2020

Effects of drotrecogin alfa activated on microcirculatory alterations in patients with severe sepsis

1 reference

12 December 2020

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24067428

1 reference