Modulation of GITR for cancer immunotherapy (Q26853557)

Crossref

Judith T Murphy

series ordinal

2

1 reference

Crossref

language of work or name

1 reference

April 2012

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Current Opinion in Immunology

published in

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volume

24

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issue

2

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page(s)

217-24

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Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR

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A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis

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Science gone translational: the OX40 agonist story

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Evolution of GITRL immune function: Murine GITRL exhibits unique structural and biochemical properties within the TNF superfamily

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Structural basis for ligand-mediated mouse GITR activation

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TNF/TNFR family members in costimulation of T cell responses

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Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells

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Combination CTLA-4 blockade and 4-1BB activation enhances tumor rejection by increasing T-cell infiltration, proliferation, and cytokine production

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Key role of the GITR/GITRLigand pathway in the development of murine autoimmune diabetes: a potential therapeutic target

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Enhancement of anti-tumor immunity through local modulation of CTLA-4 and GITR by dendritic cells

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T-cell intrinsic effects of GITR and 4-1BB during viral infection and cancer immunotherapy

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Th2 responses to helminth parasites can be therapeutically enhanced by, but are not dependent upon, GITR-GITR ligand costimulation in vivo

28 September 2017

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CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodies

28 September 2017

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Stimulation of the glucocorticoid-induced TNF receptor family-related receptor on CD8 T cells induces protective and high-avidity T cell responses to tumor-specific antigens

28 September 2017

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The glucocorticoid-induced TNF receptor family-related protein (GITR) is critical to the development of acute pancreatitis in mice

28 September 2017

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Clinical Experiences With Anti-CD137 and Anti-PD1 Therapeutic Antibodies

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Glucocorticoid‐Induced TNFR‐Related (GITR) Protein and Its Ligand in Antitumor Immunity: Functional Role and Therapeutic Modulation

28 September 2017

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Mature B Cells Are Critical to T-cell-mediated Tumor Immunity Induced by an Agonist Anti-GITR Monoclonal Antibody

28 September 2017

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Depletion of regulatory T cells by anti-GITR mAb as a novel mechanism for cancer immunotherapy

28 September 2017

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Two distinct mechanisms of augmented antitumor activity by modulation of immunostimulatory/inhibitory signals.

28 September 2017

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Agonist anti-GITR monoclonal antibody induces melanoma tumor immunity in mice by altering regulatory T cell stability and intra-tumor accumulation

28 September 2017

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Control of immunity by the TNFR-related molecule OX40 (CD134)

28 September 2017

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Combining T-cell vaccination and application of agonistic anti-GITR mAb (DTA-1) induces complete eradication of HPV oncogene expressing tumors in mice

28 September 2017

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CD137 ligand mediates opposite effects in human and mouse NK cells and impairs NK-cell reactivity against human acute myeloid leukemia cells.

28 September 2017

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GITR: a modulator of immune response and inflammation.

28 September 2017

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Dendritic cells engineered to secrete anti-GITR antibodies are effective adjuvants to dendritic cell-based immunotherapy

28 September 2017

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OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis.

28 September 2017

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T-cell modulation combined with intratumoral CpG cures lymphoma in a mouse model without the need for chemotherapy

28 September 2017

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OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection

28 September 2017

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Glucocorticoid-induced tumor necrosis factor receptor negatively regulates activation of human primary natural killer (NK) cells by blocking proliferative signals and increasing NK cell apoptosis.

28 September 2017

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Cancer immunoediting by GITR (glucocorticoid-induced TNF-related protein) ligand in humans: NK cell/tumor cell interactions

28 September 2017

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CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells

28 September 2017

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Glucocorticoid-induced TNF receptor family related gene activation overcomes tolerance/ignorance to melanoma differentiation antigens and enhances antitumor immunity.

28 September 2017

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Agonist anti-GITR antibody enhances vaccine-induced CD8(+) T-cell responses and tumor immunity

28 September 2017

1 reference

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Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL).

28 September 2017

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Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells.

28 September 2017

1 reference

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In vivo kinetics of GITR and GITR ligand expression and their functional significance in regulating viral immunopathology

28 September 2017

1 reference

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Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413251

GITR activation induces an opposite effect on alloreactive CD4(+) and CD8(+) T cells in graft-versus-host disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413251

Costimulation via glucocorticoid-induced TNF receptor in both conventional and CD25+ regulatory CD4+ T cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413251

GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413251

Role of GITR in activation response of T lymphocytes.

28 September 2017

1 reference

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CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor

28 September 2017

1 reference

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Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413251

Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand

28 September 2017

1 reference

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Down-regulation of the antitumor immune response.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413251

GITR modulates innate and adaptive mucosal immunity during the development of experimental colitis in mice.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413251

Glucocorticoid-induced tumor necrosis factor receptor stimulation enhances the multifunctionality of adoptively transferred tumor antigen-specific CD8+ T cells with tumor regression.

31 May 2018

1 reference

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Regulatory T cell-resistant CD8+ T cells induced by glucocorticoid-induced tumor necrosis factor receptor signaling.

28 November 2018

1 reference

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Role of glucocorticoid-induced TNF receptor family gene (GITR) in collagen-induced arthritis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413251

Glucocorticoid-induced TNF receptor functions as a costimulatory receptor that promotes survival in early phases of T cell activation.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413251

Triggering of OX40 (CD134) on CD4(+)CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413251

Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells.

28 November 2018

1 reference

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Glucocorticoid-induced TNF receptor family gene (GITR) knockout mice exhibit a resistance to splanchnic artery occlusion (SAO) shock.

28 November 2018

1 reference

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Cutting edge: ligation of the glucocorticoid-induced TNF receptor enhances autoreactive CD4+ T cell activation and experimental autoimmune encephalomyelitis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413251

Expression and function of 4-1BB during CD4 versus CD8 T cell responses in vivo

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413251

Regulation of murine inflammatory bowel disease by CD25+ and CD25- CD4+ glucocorticoid-induced TNF receptor family-related gene+ regulatory T cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3413251

Pivotal roles of CD4+ effector T cells in mediating agonistic anti-GITR mAb-induced-immune activation and tumor immunity in CT26 tumors

28 November 2018

1 reference

12 December 2020

Regulation of autoimmune diabetes by non-islet-specific T cells - a role for the glucocorticoid-induced TNF receptor

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12 December 2020

Proinflammatory role of glucocorticoid-induced TNF receptor-related gene in acute lung inflammation

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12 December 2020

Endogenous 4-1BB ligand plays a critical role in protection from influenza-induced disease

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Inducible T cell antigen 4-1BB. Analysis of expression and function

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12 December 2020

CD8 T cell-intrinsic GITR is required for T cell clonal expansion and mouse survival following severe influenza infection

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12 December 2020

GITR gene deletion and GITR-FC soluble protein administration inhibit multiple organ failure induced by zymosan

1 reference

12 December 2020

Genetic and pharmacological inhibition of GITR-GITRL interaction reduces chronic lung injury induced by bleomycin instillation

1 reference

12 December 2020

10.1016/J.COI.2011.12.011

Identifiers

DOI

1 reference

1 reference

1 reference

PubMed publication ID

22245556

1 reference