The primary cilium as a dual sensor of mechanochemical signals in chondrocytes (Q26863504)

Yoach Rais

series ordinal

2

1 reference

Nicolai Miosge

series ordinal

3

1 reference

Efrat Monsonego Ornan

series ordinal

4

1 reference

language of work or name

1 reference

July 2012

1 reference

Cellular and Molecular Life Sciences

1 July 2012

3 references

12 October 2019

10 August 2020

31 January 2021

4 references

12 October 2019

10 August 2020

31 January 2021

69

1 reference

issue

13

1 reference

page(s)

2101-7

1 reference

The Ciliopathies: An Emerging Class of Human Genetic Disorders

cites work

1 reference

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Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation

21 March 2017

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Matrix elasticity directs stem cell lineage specification

21 March 2017

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Intraflagellar transport (IFT) role in ciliary assembly, resorption and signalling.

21 March 2017

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21 March 2017

Intraflagellar transport

1 reference

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Localization of extracellular matrix receptors on the chondrocyte primary cilium

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates

21 March 2017

1 reference

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Fluid shear stress activation of focal adhesion kinase. Linking to mitogen-activated protein kinases

21 March 2017

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Mechanical strain induces pp60src activation and translocation to cytoskeleton in fetal rat lung cells

21 March 2017

1 reference

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Evc is a positive mediator of Ihh-regulated bone growth that localises at the base of chondrocyte cilia

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Knockdown of the intraflagellar transport protein IFT46 stimulates selective gene expression in mouse chondrocytes and affects early development in zebrafish

21 March 2017

1 reference

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Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Loss of the Tg737 protein results in skeletal patterning defects

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Activation of fibroblast procollagen alpha 1(I) transcription by mechanical strain is transforming growth factor-beta-dependent and involves increased binding of CCAAT-binding factor (CBF/NF-Y) at the proximal promoter

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Mechanical strain increases smooth muscle and decreases nonmuscle myosin expression in rat vascular smooth muscle cells

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Antisense oligonucleotides for PDGF-B and its receptor inhibit mechanical strain-induced fetal lung cell growth

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Patched1 regulates hedgehog signaling at the primary cilium

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

The ciliary proteome database: an integrated community resource for the genetic and functional dissection of cilia

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

The primary cilium as the cell's antenna: signaling at a sensory organelle

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Primary cilia modulate Ihh signal transduction in response to hydrostatic loading of growth plate chondrocytes

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

The Role of Primary Cilia in Mesenchymal Stem Cell Differentiation: A Pivotal Switch in Guiding Lineage Commitment

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Mechanics rules cell biology

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Osteocyte primary cilium and its role in bone mechanotransduction

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

The role of mechanical signals in regulating chondrogenesis and osteogenesis of mesenchymal stem cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Promiscuous and depolarization-induced immediate-early response genes are induced by mechanical strain of osteoblasts

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Modeling ciliopathies: Primary cilia in development and disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Rapid signal transduction in living cells is a unique feature of mechanotransduction.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

The Oak Ridge Polycystic Kidney mouse: modeling ciliopathies of mice and men

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Kinesin-2 controls development and patterning of the vertebrate skeleton by Hedgehog- and Gli3-dependent mechanisms

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

FAK-Mediated mechanotransduction in skeletal regeneration

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Piecing together a ciliome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Rigidity sensing at the leading edge through alphavbeta3 integrins and RPTPalpha

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Shear stress induces endothelial differentiation from a murine embryonic mesenchymal progenitor cell line

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

A physiological view of the primary cilium

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Molecular regulation of mechanotransduction

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Conversion of mechanical force into biochemical signaling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Beta1-integrins in the primary cilium of MDCK cells potentiate fibronectin-induced Ca2+ signaling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Calcium regulates the PI3K-Akt pathway in stretched osteoblasts

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

A proteomic analysis of human cilia: identification of novel components

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

The differential distribution of acetylated and detyrosinated alpha-tubulin in the microtubular cytoskeleton and primary cilia of hyaline cartilage chondrocytes.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Growth factor and cytokine gene expression in mechanically strained human osteoblast-like cells: implications for distraction osteogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Differential effects of embryonic immobilization on the development of fibrocartilaginous skeletal elements

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Mechanical force-induced signal transduction in lung cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Mechanical stressing of integrin receptors induces enhanced tyrosine phosphorylation of cytoskeletally anchored proteins.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Extracellular signal-regulated kinase and c-Jun NH2-terminal kinase activation by mechanical stretch is integrin-dependent and matrix-specific in rat cardiac fibroblasts

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Mitogen-activated protein kinase (ERK1/2) activation by shear stress and adhesion in endothelial cells. Essential role for a herbimycin-sensitive kinase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Sex differences of chondrogenic progenitor cells in late stages of osteoarthritis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Conditional Kif3a ablation causes abnormal hedgehog signaling topography, growth plate dysfunction, and excessive bone and cartilage formation during mouse skeletogenesis

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Weight loading young chicks inhibits bone elongation and promotes growth plate ossification and vascularization

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Cyclic tensile stretch inhibition of nitric oxide release from osteoblast-like cells is both G protein and actin-dependent

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Ca(2+) regulates fluid shear-induced cytoskeletal reorganization and gene expression in osteoblasts

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Electrophysiological responses of human bone cells to mechanical stimulation: evidence for specific integrin function in mechanotransduction.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

The cellular and molecular response of cardiac myocytes to mechanical stress.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Mechanical stress activates protein kinase cascade of phosphorylation in neonatal rat cardiac myocytes

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Incidence and morphology of equine and murine chondrocytic cilia

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Analysis of the morphology and function of primary cilia in connective tissues: a cellular cybernetic probe?

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

The effects of paralysis on skeletal development in the chick embryo. II. Effects on histogenesis of the tibia

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

The effects of paralysis on skeletal development in the chick embryo. I. General effects

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Cilia of adult canine articular chondrocytes

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Correction: Platelet-Derived Growth Factor B Chain Promoter Contains a Cis-Acting Fluid Shear-Stress-Responsive Element

31 May 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0911-3

Shear stress activates p60src-Ras-MAPK signaling pathways in vascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0911-3

Ultrastructural, tomographic and confocal imaging of the chondrocyte primary cilium in situ.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0911-3

Intraflagellar transport is essential for endochondral bone formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0911-3

Mechanical stress-mediated Runx2 activation is dependent on Ras/ERK1/2 MAPK signaling in osteoblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0911-3

TMJ development and growth require primary cilia function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0911-3

Mechanical loading modulates chondrocyte primary cilia incidence and length.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0911-3

Orientation of primary cilia of articular chondrocytes in three-dimensional space

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0911-3

The effect of weight loading and subsequent release from loading on the postnatal skeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0911-3

Primary cilia and signaling pathways in mammalian development, health and disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0911-3

Migratory chondrogenic progenitor cells from repair tissue during the later stages of human osteoarthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-011-0911-3

Intraflagellar transport in skeletal development.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Postnatal growth and development of a cerebral arteriovenous malformation on serial magnetic resonance imaging in a child with hemangiomatosis. Case report.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

Short-term rigid and flaccid paralyses diminish growth of embryonic chick limbs and abrogate joint cavity formation but differentially preserve pre-cavitated joints.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

TGFbeta2 mediates the effects of hedgehog on hypertrophic differentiation and PTHrP expression.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375420

The role of movement in the development of joints and related structures: the head and neck in the chick embryo

28 November 2018

1 reference

12 December 2020

Platelet-derived growth factor B chain promoter contains a cis-acting fluid shear-stress-responsive element

1 reference

12 December 2020

Neuromuscular atrophy alters collagen gene expression, pattern formation, and mechanical integrity of the chick embryo long bone

1 reference

12 December 2020

Articular cartilage and growth plate defects are associated with chondrocyte cytoskeletal abnormalities in Tg737orpk mice lacking the primary cilia protein polaris

1 reference

12 December 2020

Primary cilia in osteoarthritic chondrocytes: from chondrons to clusters

1 reference

12 December 2020

PTHrP and skeletal development

1 reference

12 December 2020

In vitroinvestigation of renal epithelial injury suggests that primary cilium length is regulated by hypoxia-inducible mechanisms

1 reference

12 December 2020

Mechanical loading and TGF-beta regulate proteoglycan synthesis in tendon

1 reference

12 December 2020

Mechanisms of coronary angiogenesis in response to stretch: role of VEGF and TGF-beta

1 reference

12 December 2020

Fluid flow induces COX-2 expression in MC3T3-E1 osteoblasts via a PKA signaling pathway

1 reference

12 December 2020

Mechanical strain increases protein tyrosine phosphorylation in airway smooth muscle cells

1 reference

12 December 2020

Confocal analysis of primary cilia structure and colocalization with the Golgi apparatus in chondrocytes and aortic smooth muscle cells

1 reference

12 December 2020

Involvement of matrix metalloproteinases in the growth plate response to physiological mechanical load

1 reference

12 December 2020

Paralysis and growth of the musculoskeletal system in the embryonic chick

1 reference

12 December 2020

Indian hedgehog is an essential component of mechanotransduction complex to stimulate chondrocyte proliferation

1 reference

12 December 2020

Intracellular Ca2+ stores and extracellular Ca2+ are required in the real-time Ca2+ response of bone cells experiencing fluid flow

1 reference

12 December 2020

10.1007/S00018-011-0911-3

Identifiers

DOI

1 reference

Dimensions Publication ID

3555589

1007548968

0 references

3555589

1 reference

1 reference

1 reference