Urzymology: experimental access to a key transition in the appearance of enzymes (Q26865900)

language of work or name

1 reference

31 October 2014

1 reference

Journal of Biological Chemistry

published in

1 reference

volume

289

1 reference

issue

44

1 reference

page(s)

30213-20

1 reference

Stability-mediated epistasis constrains the evolution of an influenza protein

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Subfunctionalization of duplicated genes as a transition state to neofunctionalization

21 March 2017

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Design of a Novel Globular Protein Fold with Atomic-Level Accuracy

21 March 2017

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21 March 2017

The universal ancestor

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An epistatic ratchet constrains the direction of glucocorticoid receptor evolution

21 March 2017

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A rationally engineered misacylating aminoacyl-tRNA synthetase

21 March 2017

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Structure and dynamics of a molten globular enzyme

21 March 2017

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Expanding the genetic code of Escherichia coli

21 March 2017

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Adding new chemistries to the genetic code

21 March 2017

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Structural phylogenomics retrodicts the origin of the genetic code and uncovers the evolutionary impact of protein flexibility

21 March 2017

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Mechanistic approaches to the study of evolution: the functional synthesis

21 March 2017

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Robustness of Ancestral Sequence Reconstruction to Phylogenetic Uncertainty

21 March 2017

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Data growth and its impact on the SCOP database: new developments

7 April 2017

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The Rodin-Ohno hypothesis that two enzyme superfamilies descended from one ancestral gene: an unlikely scenario for the origins of translation that will not be dismissed.

7 April 2017

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Enhanced amino acid selection in fully evolved tryptophanyl-tRNA synthetase, relative to its urzyme, requires domain motion sensed by the D1 switch, a remote dynamic packing motif

28 September 2017

1 reference

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Full implementation of the genetic code by tryptophanyl-tRNA synthetase requires intermodular coupling

28 September 2017

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Experiments on the role of deleterious mutations as stepping stones in adaptive evolution

28 September 2017

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Aminoacylating urzymes challenge the RNA world hypothesis

28 September 2017

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Synthetic and editing mechanisms of aminoacyl-tRNA synthetases

28 September 2017

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A phylogenetic model for the detection of epistatic interactions

28 September 2017

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Statistical evaluation of the Rodin-Ohno hypothesis: sense/antisense coding of ancestral class I and II aminoacyl-tRNA synthetases

28 September 2017

1 reference

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Essential nontranslational functions of tRNA synthetases

28 September 2017

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Benchmark reaction rates, the stability of biological molecules in water, and the evolution of catalytic power in enzymes

28 September 2017

1 reference

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Histidyl-tRNA synthetase urzymes: Class I and II aminoacyl tRNA synthetase urzymes have comparable catalytic activities for cognate amino acid activation

28 September 2017

1 reference

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Impact of temperature on the time required for the establishment of primordial biochemistry, and for the evolution of enzymes.

28 September 2017

1 reference

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Tryptophanyl-tRNA synthetase Urzyme: a model to recapitulate molecular evolution and investigate intramolecular complementation

28 September 2017

1 reference

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New functions of aminoacyl-tRNA synthetases beyond translation

28 September 2017

1 reference

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Six Rossmannoid folds, including the Class I aminoacyl-tRNA synthetases, share a partial core with the anti-codon-binding domain of a Class II aminoacyl-tRNA synthetase

28 September 2017

1 reference

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The intrinsic reactivity of ATP and the catalytic proficiencies of kinases acting on glucose, N-acetylgalactosamine, and homoserine: a thermodynamic analysis

28 September 2017

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Architectural underpinnings of the genetic code for glutamine

28 September 2017

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The structure of protein evolution and the evolution of protein structure.

28 September 2017

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A minimal TrpRS catalytic domain supports sense/antisense ancestry of class I and II aminoacyl-tRNA synthetases

28 September 2017

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Molecular paleoscience: systems biology from the past.

28 September 2017

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Residues crucial for maintaining short paths in network communication mediate signaling in proteins

28 September 2017

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Resurrecting ancient genes: experimental analysis of extinct molecules

28 September 2017

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Aminoacyl-tRNAs: setting the limits of the genetic code

28 September 2017

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Resurrecting the Ancestral Steroid Receptor: Ancient Origin of Estrogen Signaling

28 September 2017

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Functional fingerprints of folds: evidence for correlated structure-function evolution

28 September 2017

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The CATH database: an extended protein family resource for structural and functional genomics

28 September 2017

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The depth of chemical time and the power of enzymes as catalysts.

28 September 2017

1 reference

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Toprim--a conserved catalytic domain in type IA and II topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215205

Cognition, mechanism, and evolutionary relationships in aminoacyl-tRNA synthetases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4215205

An operational RNA code for amino acids and possible relationship to genetic code

28 September 2017

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Selection of a 'minimal' glutaminyl-tRNA synthetase and the evolution of class I synthetases

28 September 2017

1 reference

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Two types of aminoacyl-tRNA synthetases could be originally encoded by complementary strands of the same nucleic acid

28 September 2017

1 reference

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On the evolution of the genetic code

28 September 2017

1 reference

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A Proposed Model for Interaction of Polypeptides with RNA

28 September 2017

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Enzymatic aminoacylation of an eight-base-pair microhelix with histidine

28 September 2017

1 reference

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Is genetic code redundancy related to retention of structural information in both DNA strands?

28 September 2017

1 reference

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Understanding structural relationships in proteins of unsolved three-dimensional structure

28 September 2017

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Small RNA helices as substrates for aminoacylation and their relationship to charging of transfer RNAs

28 September 2017

1 reference

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Mg2+-assisted catalysis by B. stearothermophilus TrpRS is promoted by allosteric effects

28 September 2017

1 reference

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A conformational transition state accompanies tryptophan activation by B. stearothermophilus tryptophanyl-tRNA synthetase

31 May 2018

1 reference

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The rate enhancement produced by the ribosome: an improved model

31 May 2018

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Molecular evolution: aminoacyl-tRNA synthetases on the loose

31 May 2018

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Dissection of the structure and activity of the tyrosyl-tRNA synthetase by site-directed mutagenesis

31 May 2018

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The ribonuclease from an extinct bovid ruminant

31 May 2018

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Aminoacylation of RNA minihelices with alanine.

31 May 2018

1 reference

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Palaeotemperature trend for Precambrian life inferred from resurrected proteins

19 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R114.567495

Ancient adaptation of the active site of tryptophanyl-tRNA synthetase for tryptophan binding

21 January 2018

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RNA-catalyzed amino acid activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R114.567495

Amino acid biogenesis, evolution of the genetic code and aminoacyl-tRNA synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.R114.567495

Did tRNA synthetase classes arise on opposite strands of the same gene?

21 January 2018

1 reference

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Understanding hierarchical protein evolution from first principles 1 1Edited by J. Thornton

21 January 2018

1 reference

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A tale of two synthetases

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/25210034

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Design of an active fragment of a class II aminoacyl-tRNA synthetase and its significance for synthetase evolution

1 reference

https://pubmed.ncbi.nlm.nih.gov/25210034

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.R114.567495

0 references

Fatcat ID

release_ku4t5vvsqrh4zec76b46uoseka

0 references

1 reference

PubMed publication ID

25210034

1 reference