Neuregulin as a heart failure therapy and mediator of reverse remodeling (Q26991903)

Sergey Ryzhov

series ordinal

2

1 reference

Douglas B. Sawyer

series ordinal

3

1 reference

language of work or name

1 reference

March 2014

1 reference

Current heart failure reports

published in

1 reference

volume

11

1 reference

issue

1

1 reference

page(s)

40-9

1 reference

In vivo and in vitro genetic evidence of involvement of neuregulin 1 in immune system dysregulation

cites work

1 reference

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Association of neuregulin 1 with schizophrenia confirmed in a Scottish population

21 March 2017

1 reference

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Neuregulin 1 and susceptibility to schizophrenia

21 March 2017

1 reference

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Neuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes

21 March 2017

1 reference

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Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer

21 March 2017

1 reference

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Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

21 March 2017

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Modulation of anthracycline-induced myofibrillar disarray in rat ventricular myocytes by neuregulin-1beta and anti-erbB2: potential mechanism for trastuzumab-induced cardiotoxicity

21 March 2017

1 reference

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Cardiac dysfunction in the trastuzumab clinical trials experience

21 March 2017

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Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury

21 March 2017

1 reference

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Cardiac endothelial cells regulate reactive oxygen species-induced cardiomyocyte apoptosis through neuregulin-1beta/erbB4 signaling

21 March 2017

1 reference

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Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase

21 March 2017

1 reference

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Neuregulin-1 promotes formation of the murine cardiac conduction system

21 March 2017

1 reference

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Heat shock protein 90 stabilization of ErbB2 expression is disrupted by ATP depletion in myocytes

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Neuregulin-1 protects ventricular myocytes from anthracycline-induced apoptosis via erbB4-dependent activation of PI3-kinase/Akt

21 March 2017

1 reference

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Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy

21 March 2017

1 reference

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Multiple essential functions of neuregulin in development

21 March 2017

1 reference

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Activation of the neuregulin/ErbB system during physiological ventricular remodeling in pregnancy

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer

7 April 2017

1 reference

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An engineered bivalent neuregulin protects against doxorubicin-induced cardiotoxicity with reduced proneoplastic potential.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Time-dependent regulation of neuregulin-1β/ErbB/ERK pathways in cardiac differentiation of mouse embryonic stem cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Electrical stimulation accelerates neuromuscular junction formation through ADAM19/neuregulin/ErbB signaling in vitro

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Cardiac testing to manage cardiovascular risk in cancer patients

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Type 1 diabetes mellitus abrogates compensatory augmentation of myocardial neuregulin-1β/ErbB in response to myocardial infarction resulting in worsening heart failure

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

A common missense variant in the neuregulin 1 gene is associated with both schizophrenia and sudden cardiac death

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Intravenous glial growth factor 2 (GGF2) isoform of neuregulin-1β improves left ventricular function, gene and protein expression in rats after myocardial infarction

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Therapeutic potential of neuregulin-1 in cardiovascular disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Circulating neuregulin during the transition from stage A to stage B/C heart failure in a breast cancer cohort

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

ErbB/integrin signaling interactions in regulation of myocardial cell-cell and cell-matrix interactions

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Neuregulin in cardiovascular development and disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Neuregulin-1 effects on endothelial and blood-brain-barrier permeability after experimental injury

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Cardiac side effects of anticancer treatments: new mechanistic insights

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

BACE1 dependent neuregulin processing: review

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Pathogenic involvement of heregulin-β(1) in anti-atherogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Endothelial-derived neuregulin is an important mediator of ischaemia-induced angiogenesis and arteriogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Circulating neuregulin-1β levels vary according to the angiographic severity of coronary artery disease and ischemia

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Therapeutic effects of neuregulin-1 in diabetic cardiomyopathy rats

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Sudden deaths in psychiatric patients

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Engineered bivalent ligands to bias ErbB receptor-mediated signaling and phenotypes.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

The emerging role of innate immunity in the heart and vascular system: for whom the cell tolls

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Neuregulin-1β regulation of embryonic endothelial progenitor cell survival

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Parenteral administration of recombinant human neuregulin‐1 to patients with stable chronic heart failure produces favourable acute and chronic haemodynamic responses

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Serum Neuregulin-1beta as a Biomarker of Cardiovascular Fitness.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Metalloproteinase-dependent cleavage of neuregulin and autocrine stimulation of vascular endothelial cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Emerging role of neuregulin as a modulator of muscle metabolism

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Neuregulin-1 attenuated doxorubicin-induced decrease in cardiac troponins

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Neuregulin-1 beta is associated with disease severity and adverse outcomes in chronic heart failure.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Inhibition of ErbB2 by receptor tyrosine kinase inhibitors causes myofibrillar structural damage without cell death in adult rat cardiomyocytes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Management of cardiac health in trastuzumab-treated patients with breast cancer: updated United Kingdom National Cancer Research Institute recommendations for monitoring

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Palmitate alters neuregulin signaling and biology in cardiac myocytes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Expression of heregulin in human coronary atherosclerotic lesions.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Neuroprotection by neuregulin-1 following focal stroke is associated with the attenuation of ischemia-induced pro-inflammatory and stress gene expression

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Neuregulins: functions, forms, and signaling strategies

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Neuregulins and their receptors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

The significance of oncogene amplification in primary breast cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Mechanism-based engineering against anthracycline cardiotoxicity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Neuregulin-1 preconditioning protects the heart against ischemia/reperfusion injury through a PI3K/Akt-dependent mechanism.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Endothelium-derived neuregulin protects the heart against ischemic injury

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

CD14CD16 monocyte subset levels in heart failure patients.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Neuregulin-1 signaling in brain endothelial cells

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Trastuzumab-associated cardiac adverse effects in the herceptin adjuvant trial.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Neuregulin activates erbB2-dependent src/FAK signaling and cytoskeletal remodeling in isolated adult rat cardiac myocytes

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Dual cleavage of neuregulin 1 type III by BACE1 and ADAM17 liberates its EGF-like domain and allows paracrine signaling.

31 May 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11897-013-0176-2

Neuregulin-1 induces a negative inotropic effect in cardiac muscle: role of nitric oxide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11897-013-0176-2

Neuregulin-1beta1 rapidly modulates nitric oxide synthesis and calcium handling in rat cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11897-013-0176-2

Uncoupled eNOS annihilates neuregulin-1β-induced cardioprotection: a novel mechanism in pharmacological postconditioning in myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11897-013-0176-2

Cardiac functional improvement in rats with myocardial infarction by up-regulating cardiac myosin light chain kinase with neuregulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11897-013-0176-2

Neuregulin-1alpha and beta isoform expression in cardiac microvascular endothelial cells and function in cardiac myocytes in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11897-013-0176-2

Regulation of neuregulin/ErbB signaling by contractile activity in skeletal muscle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11897-013-0176-2

Neuregulin-1 reduces ischemia-induced brain damage in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11897-013-0176-2

Neuregulin receptors erbB2 and erbB4 in failing human myocardium -- depressed expression and attenuated activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11897-013-0176-2

Evidence that interaction between neuregulin 1 and its receptor erbB4 increases susceptibility to schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11897-013-0176-2

Sudden death in psychiatric patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11897-013-0176-2

Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11897-013-0176-2

ErbB2 is essential in the prevention of dilated cardiomyopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11897-013-0176-2

Neuregulin-1 suppresses cardiomyocyte apoptosis by activating PI3K/Akt and inhibiting mitochondrial permeability transition pore.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11897-013-0176-2

Prospects for Biological Cardiac Pacemaker Systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11897-013-0176-2

Inhibition of neuregulin-1/ErbB signaling in the rostral ventrolateral medulla leads to hypertension through reduced nitric oxide synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11897-013-0176-2

Effects of neuregulin on expression of MMP-9 and NSE in brain of ischemia/reperfusion rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11897-013-0176-2

Neuregulin induces CTGF expression in hypertrophic scarring fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11897-013-0176-2

Preventive effects of heregulin-beta1 on macrophage foam cell formation and atherosclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11897-013-0176-2

Neuregulins regulate cardiac parasympathetic activity: muscarinic modulation of beta-adrenergic activity in myocytes from mice with neuregulin-1 gene deletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11897-013-0176-2

Neuregulin-1 genotype moderates the association between job strain and early atherosclerosis in young men

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11897-013-0176-2

Serum neuregulin-1β levels are positively correlated with VEGF and angiopoietin-1 levels in patients with diabetes and unstable angina pectoris.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

NRG-1-induced cardiomyocyte hypertrophy. Role of PI-3-kinase, p70(S6K), and MEK-MAPK-RSK.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Human monocytes express amphiregulin and heregulin growth factors upon activation

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3975684

Neuregulin in Cardiac Hypertrophy in Rats With Aortic Stenosis

28 November 2018

1 reference

12 December 2020

Neuregulin-1 is neuroprotective and attenuates inflammatory responses induced by ischemic stroke

1 reference

12 December 2020

Neuregulin-1 beta attenuates doxorubicin-induced alterations of excitation-contraction coupling and reduces oxidative stress in adult rat cardiomyocytes

1 reference

12 December 2020

Systemic inflammation and cell activation reflects morbidity in chronic heart failure

1 reference

12 December 2020

Neuregulin-1/erbB-activation improves cardiac function and survival in models of ischemic, dilated, and viral cardiomyopathy

1 reference

12 December 2020

Neuregulin activation of ErbB receptors in vascular endothelium leads to angiogenesis

1 reference

12 December 2020

Plasma cytokine parameters and mortality in patients with chronic heart failure

1 reference

12 December 2020

A Phase II, randomized, double-blind, multicenter, based on standard therapy, placebo-controlled study of the efficacy and safety of recombinant human neuregulin-1 in patients with chronic heart failure

1 reference

12 December 2020

[Effects of neuregulin on cardiac myocyte apoptosis and PI-3K signal transduction pathway in rapid pacing-induced heart failure in rhesus monkeys]

1 reference

12 December 2020

Inhibition of ErbB2/neuregulin signaling augments paclitaxel-induced cardiotoxicity in adult ventricular myocytes

1 reference

12 December 2020

Enrichment of cardiac pacemaker-like cells: neuregulin-1 and cyclic AMP increase I(f)-current density and connexin 40 mRNA levels in fetal cardiomyocytes

1 reference

12 December 2020

Apoptosis-modulating interaction of the neuregulin/erbB pathway with anthracyclines in regulating Bcl-xS and Bcl-xL in cardiomyocytes

1 reference

12 December 2020

Neuregulin-1/ErbB signaling is impaired in the rat model of diabetic cardiomyopathy

1 reference

12 December 2020

Neuregulin-1 attenuates neointimal formation following vascular injury and inhibits the proliferation of vascular smooth muscle cells

1 reference

12 December 2020

Expression of the c-ErbB-2/HER2 proto-oncogene in normal hematopoietic cells

1 reference

12 December 2020

Therapeutic effects of neuregulin-1 gene transduction in rats with myocardial infarction

1 reference

12 December 2020

Further evidence for association between ErbB4 and schizophrenia and influence on cognitive intermediate phenotypes in healthy controls

1 reference

12 December 2020

Neuregulin-1 attenuates mitochondrial dysfunction in a rat model of heart failure

1 reference

12 December 2020

10.1007/S11897-013-0176-2

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1024585797

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release_qjjcurxahna6teiv4ul6xfmw4e

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https://api.fatcat.wiki/v0/release/qjjcurxahna6teiv4ul6xfmw4e

24 November 2022

mapped directly with Wikidata item

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PubMed publication ID

24234399

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