Neutrophil activity in chronic venous leg ulcers--a target for therapy? (Q26999022)

Traci A. Wilgus

series ordinal

3

1 reference

language of work or name

1 reference

2013

1 reference

Wound Repair and Regeneration

published in

1 reference

volume

21

1 reference

issue

3

1 reference

page(s)

339-51

1 reference

Pentoxifylline for treating venous leg ulcers

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

The contributions of aspirin and microbial oxygenase to the biosynthesis of anti-inflammatory resolvins: novel oxygenase products from omega-3 polyunsaturated fatty acids

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Resolvin E1 and protectin D1 activate inflammation-resolution programmes

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Using a diagnostic tool to identify elevated protease activity levels in chronic and stalled wounds: a consensus panel discussion.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Fish oil supplementation alters levels of lipid mediators of inflammation in microenvironment of acute human wounds

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Does inflammation have a role in the pathogenesis of venous ulcers? A critical review of the evidence

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Neutrophils, from marrow to microbes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Profiling in resolving inflammatory exudates identifies novel anti-inflammatory and pro-resolving mediators and signals for termination

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Emerging treatment options for venous ulceration in today's wound care practice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Resolvins and protectins: mediating solutions to inflammation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Rapid appearance of resolvin precursors in inflammatory exudates: novel mechanisms in resolution.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Resolvin E1, an EPA-derived mediator in whole blood, selectively counterregulates leukocytes and platelets

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Redox signals in wound healing

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Wound fluids: a window into the wound environment?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Leukocyte involvement in the signs and symptoms of chronic venous disease. Perspectives for therapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Venous leg ulcers - the search for a prognostic indicator.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Chemokines, cytokines, and growth factors in keratinocytes and dermal endothelial cells in the margin of chronic diabetic foot ulcers

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Ability of chronic wound fluids to degrade peptide growth factors is associated with increased levels of elastase activity and diminished levels of proteinase inhibitors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

The causes of skin damage and leg ulceration in chronic venous disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

The basic science of wound healing

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Chronic venous disease and the leukocyte-endothelium interaction: from symptoms to ulceration

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Alarmins: chemotactic activators of immune responses

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Venous ulcer: epidemiology, physiopathology, diagnosis and treatment.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Proteases and the diabetic foot syndrome: mechanisms and therapeutic implications

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Effect of defensin peptides on eukaryotic cells: primary epithelial cells, fibroblasts and squamous cell carcinoma cell lines

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Evidence of oxidative stress in chronic venous ulcers

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

The epidemiology, pathophysiology, and natural history of chronic venous disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Clinical benefits of Daflon 500 mg in the most severe stages of chronic venous insufficiency

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Therapeutic approach to chronic venous insufficiency and its complications: place of Daflon 500 mg.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Trends in the incidence of venous stasis syndrome and venous ulcer: a 25-year population-based study

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Chronic venous insufficiency and venous leg ulceration

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

The proteolytic environment of chronic wounds

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Randomised, double blind placebo controlled trial of pentoxifylline in the treatment of venous leg ulcers

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Anti-collagenolytic mechanism of action of doxycycline treatment in rheumatoid arthritis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Venous disease: from pathophysiology to quality of life

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Wound fluid from chronic leg ulcers contains elevated levels of metalloproteinases MMP-2 and MMP-9.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Distinct populations of basal keratinocytes express stromelysin-1 and stromelysin-2 in chronic wounds

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Doxycycline inhibits neutrophil (PMN)-type matrix metalloproteinases in human adult periodontitis gingiva.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Activation of the respiratory burst oxidase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

The neutrophilic leukocyte in wound repair a study with antineutrophil serum

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Tissue destruction by neutrophils

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Oxpentifylline treatment of venous ulcers of the leg

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Low-dose doxycycline therapy: effect on gingival and crevicular fluid collagenase activity in humans

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Protease and pro-inflammatory cytokine concentrations are elevated in chronic compared to acute wounds and can be modulated by collagen type I in vitro

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Differential patterns of response to doxycycline and transforming growth factor beta1 in the down-regulation of collagenases in osteoarthritic and normal human chondrocytes

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Dynamics of the matrix metalloproteinases MMP-1 and MMP-8 in acute open human dermal wounds

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Wound fluids from human pressure ulcers contain elevated matrix metalloproteinase levels and activity compared to surgical wound fluids

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Systemic tetracyclines in the treatment of noninfected corneal ulcers: a case report and proposed new mechanism of action.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Haemoconcentration and accumulation of white cells in the feet during venous stasis.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Causes of venous ulceration: a new hypothesis.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Pentoxifylline pretreatment decreases the pool of circulating activated neutrophils, in-vivo adhesion to endothelium, and improves survival from hemorrhagic shock.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Doxycycline inhibits type XI collagenolytic activity of extracts from human osteoarthritic cartilage and of gelatinase.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3795526

Venous leg ulcer: incidence and prevalence in the elderly

31 May 2018

1 reference

The transcriptional activation program of human neutrophils in skin lesions supports their important role in wound healing.

21 January 2018

1 reference

Iron and 8-isoprostane levels in acute and chronic wounds

21 January 2018

1 reference

Excessive neutrophils characterize chronic pressure ulcers

21 January 2018

1 reference

MMP-8 is the predominant collagenase in healing wounds and nonhealing ulcers

21 January 2018

1 reference

Effect of oxidised regenerated cellulose/collagen matrix on proteases in wound exudate of patients with chronic venous ulceration

21 January 2018

1 reference

Effect of chronic wound exudates and MMP-2/-9 inhibitor on angiogenesis in vitro

21 January 2018

1 reference

Collagenase-2 (MMP-8) and matrilysin-2 (MMP-26) expression in human wounds of different etiologies

21 January 2018

1 reference

Involvement of proteolytic enzymes--plasminogen activators and matrix metalloproteinases--in the pathophysiology of pressure ulcers.

21 January 2018

1 reference

Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense

21 January 2018

1 reference

Guidelines for the treatment of venous ulcers.

21 January 2018

1 reference

State-of-the-art treatment of chronic leg ulcers: A randomized controlled trial comparing vacuum-assisted closure (V.A.C.) with modern wound dressings.

21 January 2018

1 reference

Matrix metalloproteinase 13 (collagenase 3) in human rheumatoid synovium

21 January 2018

2 references

21 January 2018

12 December 2020

Modified cotton gauze dressings that selectively absorb neutrophil elastase activity in solution

1 reference

Protease inhibition by oleic acid transfer from chronic wound dressings to albumin.

21 January 2018

1 reference

Novel sulfonated hydrogel composite with the ability to inhibit proteases and bacterial growth.

21 January 2018

1 reference

Venous leg ulcer: a meta-analysis of adjunctive therapy with micronized purified flavonoid fraction

21 January 2018

1 reference

Improvement of left ventricular diastolic dynamics in prediabetic stage of a type II diabetic rat model after troglitazone treatment

21 January 2018

1 reference

Venous and non-venous leg ulcers: clinical history and appearance in a population study

21 January 2018

1 reference

12 December 2020

[Effect of vacuum assisted closure on collagenase activity in human chronic wound]

1 reference

12 December 2020

Effect of Vacuum-Assisted Closure Therapy on the expression of cytokines and proteases in wound fluid of adults with pressure ulcers

1 reference

12 December 2020

Socioeconomic impact of chronic venous insufficiency and leg ulcers

1 reference

12 December 2020

Distinct populations of stromal cells express collagenase-3 (MMP-13) and collagenase-1 (MMP-1) in chronic ulcers but not in normally healing wounds

1 reference

12 December 2020

Molecular and mechanistic validation of delayed healing rat wounds as a model for human chronic wounds

1 reference

12 December 2020

Ratios of activated matrix metalloproteinase-9 to tissue inhibitor of matrix metalloproteinase-1 in wound fluids are inversely correlated with healing of pressure ulcers

1 reference

12 December 2020

Multiplexed analysis of matrix metalloproteinases in leg ulcer tissue of patients with chronic venous insufficiency before and after compression therapy

1 reference

12 December 2020

Accelerated wound closure in neutrophil-depleted mice

1 reference

12 December 2020

Elevated expression of extracellular matrix metalloproteinase inducer (CD147) and membrane-type matrix metalloproteinases in venous leg ulcers

1 reference

12 December 2020

Ectopic localization of matrix metalloproteinase-9 in chronic cutaneous wounds

1 reference

12 December 2020

Leukocyte activity in the microcirculation of the leg in patients with chronic venous disease

1 reference

12 December 2020

Matrix metalloproteinases, gelatinase and collagenase, in chronic leg ulcers

1 reference

12 December 2020

Effect of collagen turnover and matrix metalloproteinase activity on healing of venous leg ulcers

1 reference

12 December 2020

Prognostic value of markers of collagen remodeling in venous ulcers

1 reference

12 December 2020

Fibronectin degradation in chronic wounds depends on the relative levels of elastase, alpha1-proteinase inhibitor, and alpha2-macroglobulin

1 reference

12 December 2020

S100A8/A9 deficiency in nonhealing venous leg ulcers uncovered by multiplexed antibody microarray profiling

1 reference

12 December 2020

Tissue inhibitor of metalloproteinases-1 is decreased and activated gelatinases are increased in chronic wounds

1 reference

12 December 2020

Increased matrix metalloproteinase-9 (MMP-9) activity observed in chronic wound fluid is related to the clinical severity of the ulcer

1 reference

12 December 2020

Alpha 1-antitrypsin is degraded and non-functional in chronic wounds but intact and functional in acute wounds: the inhibitor protects fibronectin from degradation by chronic wound fluid enzymes

1 reference

12 December 2020

Systemic treatment of venous leg ulcers with high doses of pentoxifylline: efficacy in a randomized, placebo-controlled trial

1 reference

12 December 2020

Plasma elastase in venous disease

1 reference

12 December 2020

Inhibition of elastase by a synthetic cotton-bound serine protease inhibitor: in vitro kinetics and inhibitor release

1 reference

12 December 2020

Induction of MMP-1, MMP-3 and TIMP-1 in normal dermal fibroblasts by chronic venous leg ulcer wound fluid*

1 reference

12 December 2020

Differential Proteomic Analysis Distinguishes Tissue Repair Biomarker Signatures in Wound Exudates Obtained from Normal Healing and Chronic Wounds

1 reference

12 December 2020

Tissue and urokinase plasminogen activators in the environs of venous and ischaemic leg ulcers

1 reference

12 December 2020

Increased levels of human neutrophil alpha-defensins in chronic venous leg ulcers

1 reference

12 December 2020

Tenascin-C degradation in chronic wounds is dependent on serine proteinase activity

1 reference

12 December 2020

Topically applied CMT-2 enhances wound healing in streptozotocin diabetic rat skin

1 reference

12 December 2020

From the NIH. Tetracyclines block collagenase activity

1 reference

12 December 2020

White cell and platelet trapping in patients with chronic venous insufficiency

1 reference

12 December 2020

The Impact of Differential Expression of Extracellular Matrix Metalloproteinase Inducer, Matrix Metalloproteinase-2, Tissue Inhibitor of Matrix Metalloproteinase-2 and PDGF-AA on the Chronicity of Venous Leg Ulcers

1 reference

12 December 2020

Analysis of the acute and chronic wound environments: the role of proteases and their inhibitors

1 reference

12 December 2020

The VEINES study (VEnous Insufficiency Epidemiologic and Economic Study): an international cohort study on chronic venous disorders of the leg. VEINES Group

1 reference

12 December 2020

Temporal expression of urokinase plasminogen activator, plasminogen activator inhibitor and gelatinase-B in chronic wound fluid switches from a chronic to acute wound profile with progression to healing

1 reference

12 December 2020

Venous leg ulcers and the family physician

1 reference

12 December 2020

[Neutrophil activation in experimental venous hypertension]

1 reference

12 December 2020

Early healing events in a porcine model of contaminated wounds: effects of nanocrystalline silver on matrix metalloproteinases, cell apoptosis, and healing

1 reference

12 December 2020

Mechanism of action of PROMOGRAN, a protease modulating matrix, for the treatment of diabetic foot ulcers

1 reference

12 December 2020

Proteolytic activity in wound fluids and tissues derived from chronic venous leg ulcers

1 reference

12 December 2020

Inappropriate neutrophil activation in venous disease

1 reference

12 December 2020

Up-regulation of elastase in acute wounds of healthy aged humans and chronic venous leg ulcers are associated with matrix degradation

1 reference

12 December 2020

The role of doxycycline as a matrix metalloproteinase inhibitor for the treatment of chronic wounds

1 reference

12 December 2020