5-HT6 receptors and Alzheimer's disease (Q27006820)

Alzheimers Research & Therapy

published in

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volume

5

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issue

2

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page(s)

15

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Effects of 5-HT6 receptor antagonism and cholinesterase inhibition in models of cognitive impairment in the rat

cites work

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The 5-HT(6) receptor antagonist SB-271046 selectively enhances excitatory neurotransmission in the rat frontal cortex and hippocampus

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Effects of 5-HT6 antagonists, Ro-4368554 and SB-258585, in tests used for the detection of cognitive enhancement and antipsychotic-like activity

21 March 2017

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5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease

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Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466

21 March 2017

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21 March 2017

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Immuno-localization of serotonin 5-HT6 receptor-like material in the rat central nervous system

21 March 2017

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A novel rat serotonin (5-HT6) receptor: molecular cloning, localization and stimulation of cAMP accumulation

21 March 2017

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Activation of the 5-HT(6) receptor attenuates long-term potentiation and facilitates GABAergic neurotransmission in rat hippocampus

21 March 2017

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Increased expression of 5-HT6 receptors in the rat dorsomedial striatum impairs instrumental learning

21 March 2017

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Lack of localization of 5-HT6 receptors on cholinergic neurons: implication of multiple neurotransmitter systems in 5-HT6 receptor-mediated acetylcholine release

21 March 2017

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Characterization of the 5-HT6 receptor coupled to Ca2+ signaling using an enabling chimeric G-protein

21 March 2017

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Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs

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Chemocentric informatics approach to drug discovery: identification and experimental validation of selective estrogen receptor modulators as ligands of 5-hydroxytryptamine-6 receptors and as potential cognition enhancers

21 March 2017

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Serotonin receptors of type 6 (5-HT6): what can we expect from them?

28 September 2017

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Activation of 5-HT6 receptors inhibits corticostriatal glutamatergic transmission.

28 September 2017

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ST1936 stimulates cAMP, Ca2+, ERK1/2 and Fyn kinase through a full activation of cloned human 5-HT6 receptors

28 September 2017

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5-HT(6) receptor and cognition.

28 September 2017

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5-HT6 receptor memory and amnesia: behavioral pharmacology--learning and memory processes

28 September 2017

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5-HT6 Medicinal Chemistry

28 September 2017

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5-hydroxytryptamine subtype 6 receptor modulators: a patent survey

28 September 2017

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E-6801, a 5-HT6 receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission in the rat.

28 September 2017

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Neurochemical basis for symptomatic treatment of Alzheimer's disease

28 September 2017

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Physical interaction of Jab1 with human serotonin 6 G-protein-coupled receptor and their possible roles in cell survival

28 September 2017

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An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function

28 September 2017

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Functional interaction between 5-HT(6) receptors and hypothalamic-pituitary-adrenal axis: cognitive implications.

28 September 2017

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Acute onset by 5-HT(6)-receptor activation on rat brain brain-derived neurotrophic factor and activity-regulated cytoskeletal-associated protein mRNA expression

28 September 2017

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SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models.

28 September 2017

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Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist

28 September 2017

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Memories are made of this (perhaps): a review of serotonin 5-HT(6) receptor ligands and their biological functions

28 September 2017

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Effects of the 5-HT(6) receptor antagonist Ro 04-6790 on learning consolidation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3706851

5-HT6 receptor ligands, EMD386088 and SB258585, differentially regulate 5-HT6 receptor-independent events

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3706851

31 May 2018

Dimebon disappointment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3706851

5-HT6 receptor blockade differentially affects scopolamine-induced deficits of working memory, recognition memory and aversive learning in mice.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3706851

Radiosynthesis and characterization of 11C-GSK215083 as a PET radioligand for the 5-HT6 receptor.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3706851

Synthesis and in vivo evaluation of [O-methyl-11C] N-[3,5-dichloro-2-(methoxy)phenyl]-4-(methoxy)-3-(1-piperazinyl)benzenesulfonamide as an imaging probe for 5-HT6 receptors

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3706851

Synthesis and structure-activity relationship of novel conformationally restricted analogues of serotonin as 5-HT6 receptor ligands

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3706851

Two novel 5-HT6 receptor antagonists ameliorate scopolamine-induced memory deficits in the object recognition and object location tasks in Wistar rats

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3706851

Lu AE58054, a 5-HT6 antagonist, reverses cognitive impairment induced by subchronic phencyclidine in a novel object recognition test in rats.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3706851

Signalling pathways associated with 5-HT6 receptors: relevance for cognitive effects

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3706851

Time-course of 5-HT(6) receptor mRNA expression during memory consolidation and amnesia

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3706851

Procognitive 5-HT6 antagonists in the rat forced swimming test: potential therapeutic utility in mood disorders associated with Alzheimer's disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3706851

Involvement of an altered 5-HT -{6} receptor function in behavioral symptoms of Alzheimer's disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3706851

Actions of novel agonists, antagonists and antipsychotic agents at recombinant rat 5-HT6 receptors: a comparative study of coupling to G alpha s.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3706851

Differential involvement of 5-HT(1B/1D) and 5-HT6 receptors in cognitive and non-cognitive symptoms in Alzheimer's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3706851

An assessment of the effects of serotonin 6 (5-HT6) receptor antagonists in rodent models of learning

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3706851

Epiminocyclohepta[b]indole analogs as 5-HT6 antagonists

28 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/23607787

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Quantitative RT-PCR distribution of serotonin 5-HT6 receptor mRNA in the central nervous system of control or 5,7-dihydroxytryptamine-treated rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/23607787

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Design, synthesis and pharmacological evaluation of conformationally restricted N-arylsulfonyl-3-aminoalkoxy indoles as a potential 5-HT6 receptor ligands

1 reference

https://pubmed.ncbi.nlm.nih.gov/23607787

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/ALZRT169

1 reference

Dimensions Publication ID

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/alzrt169

1 reference

1 reference

PubMed publication ID

23607787

1 reference