Unravelling the molecular complexity of GPCR-mediated EGFR transactivation using functional genomics approaches (Q27008332)

Walter G. Thomas

series ordinal

3

1 reference

language of work or name

1 reference

November 2013

1 reference

1 reference

280

1 reference

PubMed

issue

21

1 reference

PubMed

page(s)

5258-68

1 reference

Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse

PubMed

cites work

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Orphan G protein-coupled receptors (GPCRs): biological functions and potential drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Recombinant G-protein beta gamma-subunits activate the muscarinic-gated atrial potassium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Modulation of Ca2+ channels by G-protein beta gamma subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Involvement of chemokine receptors in breast cancer metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Thrombin receptor overexpression in malignant and physiological invasion processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Identification of endothelin–1 in the pathophysiology of metastatic adenocarcinoma of the prostate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Regulation of receptor trafficking by GRKs and arrestins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Mitogenic signaling pathways induced by G protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Ligand-independent activation of platelet-derived growth factor receptor is a necessary intermediate in lysophosphatidic, acid-stimulated mitogenic activity in L cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Transactivation of vascular endothelial growth factor (VEGF) receptor Flk-1/KDR is involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt and endothelial nitric-oxide synthase (eNOS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

The P2Y2 nucleotide receptor mediates vascular cell adhesion molecule-1 expression through interaction with VEGF receptor-2 (KDR/Flk-1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Engagement of β-arrestin by transactivated insulin-like growth factor receptor is needed for V2 vasopressin receptor-stimulated ERK1/2 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Thrombin- and factor Xa-induced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Untangling the ErbB signalling network

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

ERBB receptors and cancer: the complexity of targeted inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Requirement for neuregulin receptor erbB2 in neural and cardiac development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Severe neuropathies in mice with targeted mutations in the ErbB3 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

ErbB2 is essential in the prevention of dilated cardiomyopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Essential roles of Her2/erbB2 in cardiac development and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

5-HT2A receptor induces ERK phosphorylation and proliferation through ADAM-17 tumor necrosis factor-alpha-converting enzyme (TACE) activation and heparin-bound epidermal growth factor-like growth factor (HB-EGF) shedding in mesangial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: metalloproteinase inhibitors as a new therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Agonist-induced activation of matrix metalloproteinase-7 promotes vasoconstriction through the epidermal growth factor-receptor pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

G protein coupling and second messenger generation are indispensable for metalloprotease-dependent, heparin-binding epidermal growth factor shedding through angiotensin II type-1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Distinct ADAM metalloproteinases regulate G protein-coupled receptor-induced cell proliferation and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Neuropeptide-induced transactivation of a neuronal epidermal growth factor receptor is mediated by metalloprotease-dependent formation of heparin-binding epidermal growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Transactivation of epidermal growth factor receptor mediates catecholamine-induced growth of vascular smooth muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Mechanisms involved in PGE2-induced transactivation of the epidermal growth factor receptor in MH1C1 hepatocarcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Activated human hydroxy-carboxylic acid receptor-3 signals to MAP kinase cascades via the PLC-dependent PKC and MMP-mediated EGFR pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Multiple G-protein-coupled receptor signals converge on the epidermal growth factor receptor to promote migration and invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

GPCR-induced migration of breast carcinoma cells depends on both EGFR signal transactivation and EGFR-independent pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Persistent transactivation of EGFR and ErbB2/HER2 by protease-activated receptor-1 promotes breast carcinoma cell invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Mitochondrial reactive oxygen species mediate GPCR-induced TACE/ADAM17-dependent transforming growth factor-alpha shedding

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Thromboxane A2 receptor-mediated epidermal growth factor receptor transactivation: involvement of PKC-delta and PKC-epsilon in the shedding of epidermal growth factor receptor ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

UV-induced EGFR signal transactivation is dependent on proligand shedding by activated metalloproteases in skin cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Angiotensin II and EGF receptor cross-talk in chronic kidney diseases: a new therapeutic approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

GPCR agonist-induced transactivation of the EGFR upregulates MLC II expression and promotes hypertension in insulin-resistant rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

GPR54 (KISS1R) transactivates EGFR to promote breast cancer cell invasiveness.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Bradykinin B(2) receptor-mediated mitogen-activated protein kinase activation in COS-7 cells requires dual signaling via both protein kinase C pathway and epidermal growth factor receptor transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal growth factor receptor (EGFR) but are not required for coupling to the mitogen-activated protein (MAP) kinase signaling cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

EGFR trans-activation by urotensin II receptor is mediated by β-arrestin recruitment and confers cardioprotection in pressure overload-induced cardiac hypertrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Angiotensin II type 1 receptor-induced extracellular signal-regulated protein kinase activation is mediated by Ca2+/calmodulin-dependent transactivation of epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

beta-Arrestin mediates beta1-adrenergic receptor-epidermal growth factor receptor interaction and downstream signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Angiotensin II induces epithelial-to-mesenchymal transition in renal epithelial cells through reactive oxygen species/Src/caveolin-mediated activation of an epidermal growth factor receptor-extracellular signal-regulated kinase signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

The renin-angiotensin system and cancer: old dog, new tricks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

ADAM17 silencing by adenovirus encoding miRNA-embedded siRNA revealed essential signal transduction by angiotensin II in vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Telmisartan inhibits cell proliferation by blocking nuclear translocation of ProHB-EGF C-terminal fragment in colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Upregulation of Nox4 promotes angiotensin II-induced epidermal growth factor receptor activation and subsequent cardiac hypertrophy by increasing ADAM17 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

EGF receptor transactivation is obligatory for protein synthesis stimulation by G protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

New strategies in overcoming acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

The ERBB network: at last, cancer therapy meets systems biology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Constitutive coupling of a naturally occurring human alpha1a-adrenergic receptor genetic variant to EGFR transactivation pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Initial sequencing and analysis of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

The Sequence of the Human Genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

The art and design of genetic screens: RNA interference.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

RNAi screening: tips and techniques

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Comparative high-throughput RNAi screening methodologies in C. elegans and mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Synthetic lethal screen identification of chemosensitizer loci in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Identification of genes that regulate epithelial cell migration using an siRNA screening approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Genome-scale RNAi profiling of cell division in human tissue culture cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

GPCR screening via ERK 1/2: a novel platform for screening G protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Receptor-specific regulation of ERK1/2 activation by members of the "free fatty acid receptor" family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Modulation of L-α-lysophosphatidylinositol/GPR55 mitogen-activated protein kinase (MAPK) signaling by cannabinoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Allosteric activation of the extracellular Ca2+-sensing receptor by L-amino acids enhances ERK1/2 phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

G-protein-coupled receptors and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

G protein-coupled receptors: novel targets for drug discovery in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Fine-tuning of GPCR activity by receptor-interacting proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

β-Catenin activates the growth factor endothelin-1 in colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509

Strain-dependent epithelial defects in mice lacking the EGF receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.12509