P53/microRNA-34-induced metabolic regulation: new opportunities in anticancer therapy (Q27011547)

Jun-Nian Zheng

series ordinal

2

1 reference

Dong-Sheng Pei

series ordinal

3

1 reference

language of work or name

1 reference

21 May 2014

13 references

3 April 2019

8 September 2019

28 November 2019

11 December 2019

18 December 2019

19 December 2019

20 December 2019

14 September 2020

4 November 2020

14 November 2020

8 February 2021

31 July 2022

13 references

3 April 2019

8 September 2019

28 November 2019

11 December 2019

18 December 2019

19 December 2019

20 December 2019

14 September 2020

4 November 2020

14 November 2020

8 February 2021

31 July 2022

13

1 reference

page(s)

115

1 reference

Creative Commons Attribution 4.0 International

copyright license

12 references

3 April 2019

8 September 2019

28 November 2019

11 December 2019

18 December 2019

19 December 2019

20 December 2019

14 September 2020

4 November 2020

14 November 2020

8 February 2021

on focus list of Wikimedia project

31 July 2022

copyright status

copyrighted

0 references

ScienceSource

0 references

cites work

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The Lin28/let-7 axis regulates glucose metabolism

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Sirt1 deacetylates c-Myc and promotes c-Myc/Max association

21 March 2017

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Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha

21 March 2017

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Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

21 March 2017

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miR-34a repression of SIRT1 regulates apoptosis

21 March 2017

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Acetylation is indispensable for p53 activation

21 March 2017

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Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1

21 March 2017

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A microRNA expression signature of human solid tumors defines cancer gene targets

21 March 2017

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miR-15 and miR-16 induce apoptosis by targeting BCL2

21 March 2017

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The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

21 March 2017

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MicroRNA expression profiles classify human cancers

21 March 2017

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The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

7 April 2017

1 reference

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TIGAR, a p53-inducible regulator of glycolysis and apoptosis

21 March 2017

1 reference

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Genome-wide characterization of miR-34a induced changes in protein and mRNA expression by a combined pulsed SILAC and microarray analysis

21 March 2017

1 reference

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Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer

21 March 2017

1 reference

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A microRNA component of the p53 tumour suppressor network

21 March 2017

1 reference

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MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells

21 March 2017

1 reference

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p53 regulates mitochondrial respiration

21 March 2017

1 reference

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New aspects of an old drug--diclofenac targets MYC and glucose metabolism in tumor cells

21 March 2017

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The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

Transcriptional activation of miR-34a contributes to p53-mediated apoptosis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

miR-21-mediated tumor growth

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

FOXM1 promotes the warburg effect and pancreatic cancer progression via transactivation of LDHA expression

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

miRNAs in insulin resistance and diabetes-associated pancreatic cancer: the 'minute and miracle' molecule moving as a monitor in the 'genomic galaxy'.

28 September 2017

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p53 regulates nuclear GSK-3 levels through miR-34-mediated Axin2 suppression in colorectal cancer cells.

28 September 2017

1 reference

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Tumor suppressor p53 plays a key role in induction of both tristetraprolin and let-7 in human cancer cells

28 September 2017

1 reference

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ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

How does Lin28 let-7 control development and disease?

28 September 2017

1 reference

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MicroRNAs in metabolism and metabolic disorders

28 September 2017

1 reference

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Cellular metabolism and disease: what do metabolic outliers teach us?

28 September 2017

1 reference

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The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

SIRT1, metabolism and cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

Cellular stress induced alterations in microRNA let-7a and let-7b expression are dependent on p53

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

Epigenetic silencing of microRNA-34b/c plays an important role in the pathogenesis of malignant pleural mesothelioma.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

The rno-miR-34 family is upregulated and targets ACSL1 in dimethylnitrosamine-induced hepatic fibrosis in rats

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomas

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

Methylation-associated silencing of microRNA-34b/c in gastric cancer and its involvement in an epigenetic field defect

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

p53 activates the PANK1/miRNA-107 gene leading to downregulation of CDK6 and p130 cell cycle proteins

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

Regulation of Myc by miR-34c: A mechanism to prevent genomic instability?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

Frequent downregulation of miR-34 family in human ovarian cancers

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

Inhibitors of lactate dehydrogenase isoforms and their therapeutic potentials

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

Involvement of microRNAs in the cytotoxic effects exerted by proinflammatory cytokines on pancreatic beta-cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

MYC-induced cancer cell energy metabolism and therapeutic opportunities

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

MiR-34, SIRT1 and p53: the feedback loop

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

How does SIRT1 affect metabolism, senescence and cancer?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

MicroRNAs impair MET-mediated invasive growth

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

Effects of miR-34a on cell growth and chemoresistance in prostate cancer PC3 cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

Alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor gene

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

p53-mediated activation of miRNA34 candidate tumor-suppressor genes.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

YY1 inhibits the activation of the p53 tumor suppressor in response to genotoxic stress.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

Yin Yang 1 is a negative regulator of p53.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

The tumor suppressor p53 and histone deacetylase 1 are antagonistic regulators of the cyclin-dependent kinase inhibitor p21/WAF1/CIP1 gene.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

c-Myc transactivation of LDH-A: implications for tumor metabolism and growth

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

Lactate dehydrogenase M-subunit deficiency: a new type of hereditary exertional myopathy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

Hexokinase binding to mitochondria: a basis for proliferative energy metabolism

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest

31 May 2018

1 reference

https://api.crossref.org/works/10.1186%2F1476-4598-13-115

p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1476-4598-13-115

p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1476-4598-13-115

The interplay between MYC and HIF in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1476-4598-13-115

Hypoxic Regulation of Lactate Dehydrogenase A

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1476-4598-13-115

Dynamic analysis of the combinatorial regulation involving transcription factors and microRNAs in cell fate decisions.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4035797

MYCtranslocation-negative classical Burkitt lymphoma cases: an alternative pathogenetic mechanism involving miRNA deregulation

28 November 2018

1 reference

12 December 2020

Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc

1 reference

12 December 2020

Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

1 reference

12 December 2020

The interplay between MYC and HIF in the Warburg effect

1 reference

12 December 2020

Identifiers

DOI

10.1186/1476-4598-13-115

1 reference

Dimensions Publication ID

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/1476-4598-13-115

1 reference

1 reference

PubMed publication ID

24884974

1 reference