Chaperoning steroidal physiology: lessons from mouse genetic models of Hsp90 and its cochaperones (Q27011776)

Crossref

language of work or name

1 reference

March 2012

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Biochimica et Biophysica Acta

published in

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volume

1823

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issue

3

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page(s)

722-9

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Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults

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The molecular chaperone Hsp90α is required for meiotic progression of spermatocytes beyond pachytene in the mouse

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The p23 molecular chaperone promotes functional telomerase complexes through DNA dissociation

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Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital

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The FK506-binding immunophilin FKBP51 is transcriptionally regulated by progestin and attenuates progestin responsiveness

21 March 2017

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Evidence that peroxisome proliferator-activated receptor alpha is complexed with the 90-kDa heat shock protein and the hepatitis virus B X-associated protein 2

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A comparison of Hsp90alpha and Hsp90beta interactions with cochaperones and substrates

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Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation

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Physiological role for the cochaperone FKBP52 in androgen receptor signaling

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Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment

21 March 2017

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Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness

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The amino-terminal domain of heat shock protein 90 (hsp90) that binds geldanamycin is an ATP/ADP switch domain that regulates hsp90 conformation

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Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation

21 March 2017

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Involvement of the constitutive prostaglandin E synthase cPGES/p23 in expression of an initial prostaglandin E2 inactivating enzyme, 15-PGDH

21 March 2017

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cPGES/p23 is required for glucocorticoid receptor function and embryonic growth but not prostaglandin E2 synthesis

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Essential role for Co-chaperone Fkbp52 but not Fkbp51 in androgen receptor-mediated signaling and physiology

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Mice lacking HSP90beta fail to develop a placental labyrinth

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The tetratricopeptide repeat domain of protein phosphatase 5 mediates binding to glucocorticoid receptor heterocomplexes and acts as a dominant negative mutant

21 March 2017

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Steroid receptor interactions with heat shock protein and immunophilin chaperones

21 March 2017

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FKBP51-a selective modulator of glucocorticoid and androgen sensitivity

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Extra-adrenal glucocorticoids and mineralocorticoids: evidence for local synthesis, regulation, and function.

28 September 2017

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Transgenic overexpression of p23 induces spontaneous hydronephrosis in mice

28 September 2017

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Modulation of cardiac contractility by serine/threonine protein phosphatase type 5.

28 September 2017

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Uterine FK506-binding protein 52 (FKBP52)-peroxiredoxin-6 (PRDX6) signaling protects pregnancy from overt oxidative stress

28 September 2017

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Fkbp52 regulates androgen receptor transactivation activity and male urethra morphogenesis

28 September 2017

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Susceptibility to diet-induced hepatic steatosis and glucocorticoid resistance in FK506-binding protein 52-deficient mice.

28 September 2017

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FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells

28 September 2017

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The hsp90-FKBP52 complex links the mineralocorticoid receptor to motor proteins and persists bound to the receptor in early nuclear events.

28 September 2017

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FKBP51 and Cyp40 are positive regulators of androgen-dependent prostate cancer cell growth and the targets of FK506 and cyclosporin A.

28 September 2017

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Characterization of cytoplasmic caspase-2 activation by induced proximity.

28 September 2017

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FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt.

28 September 2017

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Estrogen inhibits glucocorticoid action via protein phosphatase 5 (PP5)-mediated glucocorticoid receptor dephosphorylation

28 September 2017

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Long-range activation of FKBP51 transcription by the androgen receptor via distal intronic enhancers

28 September 2017

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Pharmacogenetics of antidepressant response: an update

28 September 2017

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Targeted ablation reveals a novel role of FKBP52 in gene-specific regulation of glucocorticoid receptor transcriptional activity.

28 September 2017

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Deficiency of immunophilin FKBP52 promotes endometriosis

28 September 2017

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Control of glucocorticoid and progesterone receptor subcellular localization by the ligand-binding domain is mediated by distinct interactions with tetratricopeptide repeat proteins.

28 September 2017

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A novel FK506-like binding protein interacts with the glucocorticoid receptor and regulates steroid receptor signaling

28 September 2017

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Minireview: the intersection of steroid receptors with molecular chaperones: observations and questions

28 September 2017

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Elevated levels of Ser/Thr protein phosphatase 5 (PP5) in human breast cancer

28 September 2017

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The role of serine/threonine protein phosphatase type 5 (PP5) in the regulation of stress-induced signaling networks and cancer

28 September 2017

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28 September 2017

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Noncatalytic role of the FKBP52 peptidyl-prolyl isomerase domain in the regulation of steroid hormone signaling

28 September 2017

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FKBP52 deficiency-conferred uterine progesterone resistance is genetic background and pregnancy stage specific

28 September 2017

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Mice lacking protein phosphatase 5 are defective in ataxia telangiectasia mutated (ATM)-mediated cell cycle arrest

28 September 2017

1 reference

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Prostaglandin E receptors

28 September 2017

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The Hsp90 cochaperone p23 is essential for perinatal survival.

28 September 2017

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FK506-binding protein 52 is essential to uterine reproductive physiology controlled by the progesterone receptor A isoform

28 September 2017

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The cochaperone p23 differentially regulates estrogen receptor target genes and promotes tumor cell adhesion and invasion

28 September 2017

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Chaperoning steroid hormone action

28 September 2017

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Androgen mediated regulation and functional implications of fkbp51 expression in prostate cancer

28 September 2017

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Differential control of glucocorticoid receptor hormone-binding function by tetratricopeptide repeat (TPR) proteins and the immunosuppressive ligand FK506.

28 September 2017

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FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells.

28 September 2017

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28 September 2017

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Constitutive over expression of serine/threonine protein phosphatase 5 (PP5) augments estrogen-dependent tumor growth in mice

28 September 2017

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Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver

28 September 2017

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Role of molecular chaperones in steroid receptor action

28 September 2017

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Identification and validation of novel androgen-regulated genes in prostate cancer

28 September 2017

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Inhibition of GR-mediated transcription by p23 requires interaction with Hsp90.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3288325

Heat shock protein-90 (Hsp90) acts as a repressor of peroxisome proliferator-activated receptor-alpha (PPARalpha) and PPARbeta activity

28 September 2017

1 reference

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The Hsp90-binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo

28 September 2017

1 reference

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Identification of a functional link for the p53 tumor suppressor protein in dexamethasone-induced growth suppression

28 September 2017

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Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues

28 September 2017

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Effect of geldanamycin on androgen receptor function and stability

28 September 2017

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Digital expression profiles of the prostate androgen-response program

28 September 2017

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Silymarin inhibits function of the androgen receptor by reducing nuclear localization of the receptor in the human prostate cancer cell line LNCaP.

28 September 2017

1 reference

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Glucocorticoids and lung development in the fetus and preterm infant

28 September 2017

1 reference

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Identification of an estrogen-inducible phosphatase (PP5) that converts MCF-7 human breast carcinoma cells into an estrogen-independent phenotype when expressed constitutively

28 September 2017

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Dysregulated expression of androgen-responsive and nonresponsive genes in the androgen-independent prostate cancer xenograft model CWR22-R1.

28 September 2017

1 reference

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Signaling pathways in insulin action: molecular targets of insulin resistance

28 September 2017

1 reference

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Hsp90 & Co. - a holding for folding

28 September 2017

1 reference

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Purification of a fatty acid-stimulated protein-serine/threonine phosphatase from bovine brain and its identification as a homolog of protein phosphatase 5.

28 September 2017

1 reference

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Direct stoichiometric evidence that the untransformed Mr 300,000, 9S, glucocorticoid receptor is a core unit derived from a larger heteromeric complex

28 September 2017

1 reference

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Glucocorticoid receptor is required for skin barrier competence

28 September 2017

1 reference

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Direct, androgen receptor-mediated regulation of the FKBP5 gene via a distal enhancer element.

31 May 2018

1 reference

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Development of a monoclonal antibody to the rabbit 8.5S uterine progestin receptor.

31 May 2018

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A 59-kilodalton protein associated with progestin, estrogen, androgen, and glucocorticoid receptors.

31 May 2018

1 reference

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Evidence that the 90-kDa heat shock protein is necessary for the steroid binding conformation of the L cell glucocorticoid receptor

31 May 2018

1 reference

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A 90,000-dalton binding protein common to both steroid receptors and the Rous sarcoma virus transforming protein, pp60v-src

31 May 2018

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Reduced levels of hsp90 compromise steroid receptor action in vivo

31 May 2018

1 reference

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The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress.

31 May 2018

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Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls

28 November 2018

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Genetic variants in FKBP5 affecting response to antidepressant drug treatment.

28 November 2018

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Heat shock protein 90beta: a novel mediator of vitamin D action

28 November 2018

1 reference

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Knockout mice lacking cPGES/p23, a constitutively expressed PGE2 synthetic enzyme, are peri-natally lethal.

28 November 2018

1 reference

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Identification of amino acids in the tetratricopeptide repeat and C-terminal domains of protein phosphatase 5 involved in autoinhibition and lipid activation

28 November 2018

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The cyclophilin component of the unactivated estrogen receptor contains a tetratricopeptide repeat domain and shares identity with p59 (FKBP59).

28 November 2018

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Evidence that the 90-kDa phosphoprotein associated with the untransformed L-cell glucocorticoid receptor is a murine heat shock protein

28 November 2018

1 reference

12 December 2020

In contrast to the glucocorticoid receptor, the thyroid hormone receptor is translated in the DNA binding state and is not associated with hsp90

1 reference

12 December 2020

Purification of unactivated progesterone receptor and identification of novel receptor-associated proteins

1 reference

12 December 2020

The non-DNA-binding heterooligomeric form of mammalian steroid hormone receptors contains a hsp90-bound 59-kilodalton protein

1 reference

12 December 2020

Structural and functional reconstitution of the glucocorticoid receptor-hsp90 complex

1 reference

12 December 2020

Activation of protein phosphatase 5 by limited proteolysis or the binding of polyunsaturated fatty acids to the TPR domain

1 reference

12 December 2020

The Ah receptor is a sensitive target of geldanamycin-induced protein turnover

1 reference

12 December 2020

10.1016/J.BBAMCR.2011.11.006

Identifiers

DOI

1 reference

4351409

4351409

1 reference

1 reference

1 reference