Immunomodulatory effects of low dose chemotherapy and perspectives of its combination with immunotherapy (Q27027093)

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12 February 2020

title

Immunomodulatory effects of low dose chemotherapy and perspectives of its combination with immunotherapy (English)

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12 February 2020

author name string

Mariana S Nars

series ordinal

1

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12 February 2020

language of work or name

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21 September 2012

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International Journal of Cancer

12 February 2020

published in

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PubMed

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12 February 2020

volume

132

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PubMed

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12 February 2020

page(s)

2471-2478

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12 February 2020

issue

11

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PubMed

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Platinum neurotoxicity pharmacogenetics

12 February 2020

cites work

1 reference

Lung infections after cancer chemotherapy

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Chemotherapy-induced immunosuppression

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Changes in cellular immunity during chemotherapy for primary breast cancer with anthracycline regimens.

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Chemotherapy and neutropenia

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100 years of lung cancer

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Combined inhibition of Notch signaling and Bcl-2/Bcl-xL results in synergistic antimyeloma effect

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Adaptive immunity maintains occult cancer in an equilibrium state

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Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity

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Combination of low-dose cisplatin and recombinant xenogeneic endoglin as a vaccine induces synergistic antitumor activities.

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Localised and unresectable neuroblastoma in infants: excellent outcome with low-dose primary chemotherapy

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High-Dose celecoxib and metronomic "low-dose" cyclophosphamide is an effective and safe therapy in patients with relapsed and refractory aggressive histology non-Hodgkin's lymphoma.

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Phase II clinical trial results involving treatment with low-dose daily oral cyclophosphamide, weekly vinblastine, and rofecoxib in patients with advanced solid tumors

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T(H)17 cells in tumour immunity and immunotherapy.

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Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients

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CD4+CD25+ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative

21 January 2018

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Inhibition of CD4(+)25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide

21 January 2018

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Immunogenic chemotherapy with cyclophosphamide and doxorubicin against established murine carcinoma.

21 January 2018

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Low-dose cyclophosphamide synergizes with dendritic cell-based immunotherapy in antitumor activity

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Cyclophosphamide resets dendritic cell homeostasis and enhances antitumor immunity through effects that extend beyond regulatory T cell elimination

21 January 2018

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Combination strategies for enhancing the efficacy of immunotherapy in cancer patients

21 January 2018

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Characterization of a common precursor population for dendritic cells

21 January 2018

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Regulation by chemokines of circulating dendritic cell precursors, and the formation of portal tract-associated lymphoid tissue, in a granulomatous liver disease

21 January 2018

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Chemomodulation of human dendritic cell function by antineoplastic agents in low noncytotoxic concentrations

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Phase II clinical trial of bevacizumab and low-dose metronomic oral cyclophosphamide in recurrent ovarian cancer: a trial of the California, Chicago, and Princess Margaret Hospital phase II consortia

21 January 2018

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A novel synergistic combination of cyclophosphamide and gene transfer of interleukin-12 eradicates colorectal carcinoma in mice

21 January 2018

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Recruitment of latent pools of high-avidity CD8(+) T cells to the antitumor immune response

21 January 2018

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Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells

21 January 2018

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Does surgery modify growth kinetics of breast cancer micrometastases?

21 January 2018

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Low-dose metronomic daily cyclophosphamide and weekly tirapazamine: a well-tolerated combination regimen with enhanced efficacy that exploits tumor hypoxia.

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Effect of p53 status on tumor response to antiangiogenic therapy.

21 January 2018

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Low-dose paclitaxel prior to intratumoral dendritic cell vaccine modulates intratumoral cytokine network and lung cancer growth

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Chemotherapy enhances tumor cell susceptibility to CTL-mediated killing during cancer immunotherapy in mice

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Low-dose paclitaxel enhances the anti-tumor efficacy of GM-CSF surface-modified whole-tumor-cell vaccine in mouse model of prostate cancer

21 January 2018

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Low-dose metronomic paclitaxel chemotherapy suppresses breast tumors and metastases in mice

21 January 2018

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A combination of chemoimmunotherapies can efficiently break self-tolerance and induce antitumor immunity in a tolerogenic murine tumor model

21 January 2018

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Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity

21 January 2018

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Dose/dense metronomic chemotherapy with fractioned cisplatin and oral daily etoposide enhances the anti-angiogenic effects of bevacizumab and has strong antitumor activity in advanced non-small-cell-lung cancer patients.

21 January 2018

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Cetuximab ± chemotherapy enhances dendritic cell-mediated phagocytosis of colon cancer cells and ignites a highly efficient colon cancer antigen-specific cytotoxic T-cell response in vitro.

21 January 2018

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Chemotherapeutic agents in noncytotoxic concentrations increase antigen presentation by dendritic cells via an IL-12-dependent mechanism

21 January 2018

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Signal 3 determines tolerance versus full activation of naive CD8 T cells: dissociating proliferation and development of effector function

21 January 2018

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Signals required for programming effector and memory development by CD8+ T cells

21 January 2018

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The key role of CD40 ligand in overcoming tumor-induced dendritic cell dysfunction

21 January 2018

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Cytokine-mediated protection of human dendritic cells from prostate cancer-induced apoptosis is regulated by the Bcl-2 family of proteins

21 January 2018

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Paclitaxel promotes differentiation of myeloid-derived suppressor cells into dendritic cells in vitro in a TLR4-independent manner

21 January 2018

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Chemotherapeutic agents in low noncytotoxic concentrations increase immunogenicity of human colon cancer cells.

21 January 2018

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Immunogenic anti-cancer chemotherapy as an emerging concept

21 January 2018

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Immunogenic cancer cell death: a key-lock paradigm

21 January 2018

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Calreticulin exposure dictates the immunogenicity of cancer cell death

21 January 2018

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Cancer immunotherapy by dendritic cells

21 January 2018

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Dual therapeutic efficacy of vinblastine as a unique chemotherapeutic agent capable of inducing dendritic cell maturation

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Chemoimmunotherapy of Tumors: Cyclophosphamide Synergizes with Exosome Based Vaccines

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21 January 2018

Identifiers

DOI

10.1002/IJC.27801

2 references

Consolidated OpenCitations Corpus – April 2017

4701727

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12 February 2020

4701727

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

2 references

4701727

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22927096%20AND%20SRC:MED&resulttype=core&format=json