Role of Microenvironment in Resistance to Therapy in AML (Q27027502)

language of work or name

1 reference

June 2015

1 reference

Current hematologic malignancy reports

published in

1 reference

volume

10

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issue

2

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page(s)

96-103

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LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism

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Hematopoietic stem cell niche maintenance during homeostasis and regeneration

21 March 2017

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Advances in understanding the leukaemia microenvironment

21 March 2017

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The biology of VEGF and its receptors

21 March 2017

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Stroma-mediated dysregulation of myelopoiesis in mice lacking I kappa B alpha

21 March 2017

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Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche

21 March 2017

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Accessories to the crime: functions of cells recruited to the tumor microenvironment

21 March 2017

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Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

7 April 2017

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Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches

7 April 2017

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Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

7 April 2017

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Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1

7 April 2017

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Osteoblastic cells regulate the haematopoietic stem cell niche

7 April 2017

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The relationship between the spleen colony-forming cell and the haemopoietic stem cell

7 April 2017

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Acute myelogenous leukemia-induced sympathetic neuropathy promotes malignancy in an altered hematopoietic stem cell niche

7 April 2017

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Reciprocal leukemia-stroma VCAM-1/VLA-4-dependent activation of NF-κB mediates chemoresistance

28 September 2017

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The bone marrow niche for haematopoietic stem cells

28 September 2017

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Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts

28 September 2017

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Niche-based screening identifies small-molecule inhibitors of leukemia stem cells

28 September 2017

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Arteriolar niches maintain haematopoietic stem cell quiescence.

28 September 2017

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TGF-β-Neutralizing Antibody 1D11 Enhances Cytarabine-Induced Apoptosis in AML Cells in the Bone Marrow Microenvironment

28 September 2017

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Dynamic chemotherapy-induced upregulation of CXCR4 expression: a mechanism of therapeutic resistance in pediatric AML.

28 September 2017

1 reference

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Chemotherapy-induced bone marrow nerve injury impairs hematopoietic regeneration.

28 September 2017

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Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment

28 September 2017

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CD44 integrates signaling in normal stem cell, cancer stem cell and (pre)metastatic niches

28 September 2017

1 reference

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Acute myeloid leukaemia in adults

28 September 2017

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The bone marrow microenvironment as niche retreats for hematopoietic and leukemic stem cells

28 September 2017

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BMS-936564/MDX-1338: a fully human anti-CXCR4 antibody induces apoptosis in vitro and shows antitumor activity in vivo in hematologic malignancies

28 September 2017

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Silicate modulates the cross-talk between osteoblasts (SaOS-2) and osteoclasts (RAW 264.7 cells): inhibition of osteoclast growth and differentiation

28 September 2017

1 reference

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Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow

28 September 2017

1 reference

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Endothelial and perivascular cells maintain haematopoietic stem cells

28 September 2017

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The vascular niche: home for normal and malignant hematopoietic stem cells

28 September 2017

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In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche.

28 September 2017

1 reference

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Inhibition of osteoclast function reduces hematopoietic stem cell numbers in vivo

28 September 2017

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The essential functions of adipo-osteogenic progenitors as the hematopoietic stem and progenitor cell niche.

28 September 2017

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Regulation of the HIF-1alpha level is essential for hematopoietic stem cells

28 September 2017

1 reference

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The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche.

28 September 2017

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Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches.

28 September 2017

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Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia.

28 September 2017

1 reference

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Therapeutic targeting of microenvironmental interactions in leukemia: mechanisms and approaches

28 September 2017

1 reference

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Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447522

Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447522

Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100.

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447522

CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4447522

Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML.

28 September 2017

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Uncertainty in the niches that maintain haematopoietic stem cells

28 September 2017

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Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1alpha

28 September 2017

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A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency

28 September 2017

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Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1.

28 September 2017

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Targeting of CD44 eradicates human acute myeloid leukemic stem cells

28 September 2017

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Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow

28 September 2017

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Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor

28 September 2017

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TGF-beta regulates the mechanical properties and composition of bone matrix

28 September 2017

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Relation between CXCR-4 expression, Flt3 mutations, and unfavorable prognosis of adult acute myeloid leukemia

28 September 2017

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Stromal abnormalities in neoplastic bone marrow diseases

28 September 2017

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Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche.

28 September 2017

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Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment

31 May 2018

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The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML.

31 May 2018

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Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment

31 May 2018

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Disrupting the stem cell niche: good seeds in bad soil.

31 May 2018

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Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias.

21 January 2018

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Activation of the HIF pathway in childhood ALL, prognostic implications of VEGF.

21 January 2018

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Myelodysplastic cells in patients reprogram mesenchymal stromal cells to establish a transplantable stem cell niche disease unit.

21 January 2018

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Tumour microenvironment: Destroying leukaemia stem cell habitats.

21 January 2018

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4 1 integrin and 190-kDa CD44v constitute a cell surface docking complex for gelatinase B/MMP-9 in chronic leukemic but not in normal B cells

21 January 2018

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Rewiring the niche: sympathetic neuropathy drives malignant niche transformation

21 January 2018

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12 December 2020

Disease progression in myelodysplastic syndromes: do mesenchymal cells pave the way?

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12 December 2020

SnapShot: The hematopoietic stem cell niche

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12 December 2020

Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells

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12 December 2020

Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche

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12 December 2020

10.1007/S11899-015-0253-6

Identifiers

DOI

1 reference

Dimensions Publication ID

1048985682

0 references

1 reference

1 reference

PubMed publication ID

25921386

1 reference