glasdegib (Q27077810)

Glasdegib (English)

3 October 2016

C₂₁H₂₂N₆O

1 reference

Glasdegib (English)

3 October 2016

CN1CCC(CC1C2=NC3=CC=CC=C3N2)NC(=O)NC4=CC=C(C=C4)C#N

1 reference

Glasdegib (English)

3 October 2016

CN1CC[C@H](C[C@@H]1C2=NC3=CC=CC=C3N2)NC(=O)NC4=CC=C(C=C4)C#N

1 reference

Glasdegib (English)

3 October 2016

17.4 hour

1 reference

https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/210656s002s004lbl.pdf

physically interacts with

Smoothened, frizzled class receptor

subject has role

antagonist

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2043437

legal status (medicine)

boxed warning

1 reference

https://nctr-crs.fda.gov/fdalabel/ui/spl-summaries/criteria/343802

LiverTox likelihood score

FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links. (English)

LiverTox toxicity likelihood category E*

1 reference

8 April 2021

https://www.ncbi.nlm.nih.gov/books/n/livertox/Glasdegib

last update

20 January 2019

Identifiers

InChI

InChI=1S/C21H22N6O/c1-27-11-10-16(24-21(28)23-15-8-6-14(13-22)7-9-15)12-19(27)20-25-17-4-2-3-5-18(17)26-20/h2-9,16,19H,10-12H2,1H3,(H,25,26)(H2,23,24,28)/t16-,19-/m1/s1

1 reference

Glasdegib (English)

3 October 2016

1 reference

Global Substance Registration System

Glasdegib (English)

3 October 2016

2 references

UNII

K673DMO5H9

GLASDEGIB (English)

3 October 2016

https://commonchemistry.cas.org/detail?cas_rn=1095173-27-5

9 April 2021

1 reference

Glasdegib (English)

3 October 2016

2 references

English

Glasdegib (English)

3 October 2016

ChEBI ID

145428

mapping relation type

exact match

2 references

ChEBI release 2021-03-01

International Chemical Identifier

InChI

InChI=1S/C21H22N6O/c1-27-11-10-16(24-21(28)23-15-8-6-14(13-22)7-9-15)12-19(27)20-25-17-4-2-3-5-18(17)26-20/h2-9,16,19H,10-12H2,1H3,(H,25,26)(H2,23,24,28)/t16-,19-/m1/s1

1 reference

GLASDEGIB (English)

3 October 2016

2 references

inferred from InChIKey

1 reference

1 reference

LiverTox ID

Glasdegib

0 references

EC number

813-776-8

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

100.244.738

27 December 2018

ECHA Substance Infocard ID

1-((2R,4R)-2-(1H-benzo[d]iMidazol-2-yl)-1-Methylpiperidin-4-yl)-3-(4-cyanophenyl)urea (English)

quotation

CAS no.: 1095173-27-5 (English)

100.244.738

1 reference

ECHA Substance Infocard database

ECHA Substance Infocard ID

100.244.738

27 December 2018

1-((2R,4R)-2-(1H-benzo[d]iMidazol-2-yl)-1-Methylpiperidin-4-yl)-3-(4-cyanophenyl)urea (English)

quotation

CAS no.: 1095173-27-5 (English)

ATC code

L01XX63

1 reference

https://www.ema.europa.eu/en/medicines/human/summaries-opinion/daurismo

https://www.whocc.no/atc_ddd_index/?code=L01XX63

Guide to Pharmacology Ligand ID

8201

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

8201

glasdegib (English)

3 October 2016

0 references

1 reference

UNII

K673DMO5H9

2 references

Global Substance Registration System

UNII

K673DMO5H9

English

GLASDEGIB (English)

3 October 2016