methymycin (Q27110190)

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chemical compound
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Language Label Description Also known as
English
methymycin
chemical compound

    Statements

    subclass of
    macrolides
    0 references
    polyketide
    0 references
    mass
    469.304±0 dalton
    1 reference
    stated in
    PubChem
    PubChem CID
    5282034
    language of work or name
    English
    title
    Methymycin (English)
    retrieved
    19 October 2016
    chemical formula
    C₂₅H₄₃NO₇
    1 reference
    stated in
    PubChem
    PubChem CID
    5282034
    language of work or name
    English
    title
    Methymycin (English)
    retrieved
    19 October 2016
    canonical SMILES
    CCC1C(C=CC(=O)C(CC(C(C(C(=O)O1)C)OC2C(C(CC(O2)C)N(C)C)O)C)C)(C)O
    1 reference
    stated in
    PubChem
    PubChem CID
    5282034
    language of work or name
    English
    title
    Methymycin (English)
    retrieved
    19 October 2016
    isomeric SMILES
    CC[C@@H]1[C@@](/C=C/C(=O)[C@@H](C[C@@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2[C@@H]([C@H](C[C@H](O2)C)N(C)C)O)C)C)(C)O
    1 reference
    stated in
    PubChem
    PubChem CID
    5282034
    language of work or name
    English
    title
    Methymycin (English)
    retrieved
    19 October 2016
    found in taxon
    Streptomyces venezuelae
    19 references
    stated in
    Isolation and characterization of 10-deoxymethynolide produced by Streptomyces venezuelae
    stated in
    A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity
    stated in
    Macrolide biosynthesis. 7. Incorporation of polyketide chain elongation intermediates into methymycin
    stated in
    Methymycin Biosynthesis. Isolation of P450 Monooxygenase Activity in a Cell-Free System fromStreptomycesvenezuelae
    stated in
    Biosynthesis of Desosamine: Molecular Evidence Suggesting β-Glucosylation as a Self-Resistance Mechanism in Methymycin/Neomethymycin Producing Strain,Streptomyces venezuelae
    stated in
    Biosynthesis of Desosamine: Construction of a New Methymycin/Neomethymycin Analogue by Deletion of a Desosamine Biosynthetic Gene
    stated in
    Isolation and structure determination of novamethymycin, a new bioactive metabolite of the methymycin biosynthetic pathway in Streptomyces venezuelae
    stated in
    The Streptomyces venezuelae pikAV gene contains a transcription unit essential for expression of enzymes involved in glycosylation of narbonolide and 10-deoxymethynolide
    stated in
    The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae
    stated in
    Cytochrome P450 (CYP105F2) from Streptomyces peucetius and its activity with oleandomycin.
    stated in
    New methymycin derivatives of Streptomyces venezuelae ATCC 15439 and their inhibitory effects on human T cell proliferation mediated by PMA/ionomycin
    stated in
    The structure of DesR fromStreptomyces venezuelae, a β-glucosidase involved in macrolide activation
    stated in
    Complete genome sequence of Streptomyces venezuelae ATCC 15439, a promising cell factory for production of secondary metabolites
    stated in
    Complete Genome Sequence of Streptomyces venezuelae ATCC 15439, Producer of the Methymycin/Pikromycin Family of Macrolide Antibiotics, Using PacBio Technology.
    stated in
    Production of pikromycin using branched chain amino acid catabolism in Streptomyces venezuelae ATCC 15439
    stated in
    Hydroxylation of macrolactones YC-17 and narbomycin is mediated by the pikC-encoded cytochrome P450 in Streptomyces venezuelae.
    stated in
    Macrolide biosynthesis: a single cytochrome P450, PicK, is responsible for the hydroxylations that generate methymycin, neomethymycin, and picromycin in Streptomyces venezuelae.
    stated in
    Isolation and structure determination of novamethymycin, a new bioactive metabolite of the methymycin biosynthetic pathway in Streptomyces venezuelae
    stated in
    Distribution of chloramphenicol acetyltransferase and chloramphenicol-3-acetate esterase among Streptomyces and Corynebacterium

    Identifiers

    Reaxys registry number
    61348
    1 reference
    stated in
    ChEBI
    ChEBI ID
    29630
    language of work or name
    English
    title
    methymycin (English)
    retrieved
    19 October 2016
    KEGG ID
    C11996
    1 reference
    stated in
    ChEBI
    ChEBI ID
    29630
    language of work or name
    English
    title
    methymycin (English)
    retrieved
    19 October 2016
    PDB ligand ID
    MT9
    0 references
     
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