Ensemble force changes that result from human cardiac myosin mutations and a small-molecule effector (Q27320554)

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7 March 2020

title

Ensemble force changes that result from human cardiac myosin mutations and a small-molecule effector (English)

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7 March 2020

1

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7 March 2020

author name string

Elizabeth Choe Yu

2

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7 March 2020

Shirley Sutton

3

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7 March 2020

Kathleen M Ruppel

4

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7 March 2020

James A Spudich

5

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7 March 2020

language of work or name

English

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publication date

30 April 2015

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7 March 2020

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7 March 2020

volume

11

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7 March 2020

issue

6

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7 March 2020

page(s)

910-920

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Arginine residues at internal positions in a protein are always charged

7 March 2020

cites work

1 reference

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21 March 2017

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A helix propensity scale based on experimental studies of peptides and proteins

21 March 2017

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21 March 2017

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Mutations in sarcomere protein genes as a cause of dilated cardiomyopathy

21 March 2017

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Structural implications of β-cardiac myosin heavy chain mutations in human disease

21 March 2017

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Discovery of omecamtiv mecarbil the first, selective, small molecule activator of cardiac Myosin.

28 September 2017

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Hypertrophic and dilated cardiomyopathy: four decades of basic research on muscle lead to potential therapeutic approaches to these devastating genetic diseases

28 September 2017

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The hypertrophic cardiomyopathy myosin mutation R453C alters ATP binding and hydrolysis of human cardiac β-myosin

28 September 2017

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Left ventricular noncompaction cardiomyopathy: updated review

28 September 2017

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Dilated cardiomyopathy: the complexity of a diverse genetic architecture.

28 September 2017

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Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human β-cardiac myosin motor function

28 September 2017

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Erratum to: Identification of functional differences between recombinant human α and β cardiac myosin motors.

28 September 2017

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Dose-dependent augmentation of cardiac systolic function with the selective cardiac myosin activator, omecamtiv mecarbil: a first-in-man study

28 September 2017

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How do mutations in contractile proteins cause the primary familial cardiomyopathies?

28 September 2017

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Cardiac myosin activation: a potential therapeutic approach for systolic heart failure

28 September 2017

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Cardiomyopathy-linked myosin regulatory light chain mutations disrupt myosin strain-dependent biochemistry

28 September 2017

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Insights into human beta-cardiac myosin function from single molecule and single cell studies

28 September 2017

1 reference

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The molecular basis of frictional loads in the in vitro motility assay with applications to the study of the loaded mechanochemistry of molecular motors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4431957

Functional diversity among a family of human skeletal muscle myosin motors

28 September 2017

1 reference

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Molecular basis of hereditary cardiomyopathy: abnormalities in calcium sensitivity, stretch response, stress response and beyond

28 September 2017

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A peptide tag system for facile purification and single-molecule immobilization

28 September 2017

1 reference

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R403Q and L908V mutant beta-cardiac myosin from patients with familial hypertrophic cardiomyopathy exhibit enhanced mechanical performance at the single molecule level

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4431957

Myosin II folding is mediated by a molecular chaperonin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4431957

Functional analysis of the mutations in the human cardiac beta-myosin that are responsible for familial hypertrophic cardiomyopathy. Implication for the clinical outcome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4431957

Are actin filaments moving under unloaded conditions in the in vitro motility assay?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4431957

Velocity of sarcomere shortening in rat cardiac muscle: relationship to force, sarcomere length, calcium and time

28 September 2017

1 reference

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Smooth muscle myosin cross-bridge interactions modulate actin filament sliding velocity in vitro

28 September 2017

1 reference

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Actin-binding proteins regulate the work performed by myosin II motors on single actin filaments

28 September 2017

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Tracking single particles and elongated filaments with nanometer precision

28 September 2017

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Omecamtiv Mecarbil modulates the kinetic and motile properties of porcine β-cardiac myosin

31 May 2018

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A novel beta-myosin heavy chain gene mutation, p.Met531Arg, identified in isolated left ventricular non-compaction in humans, results in left ventricular hypertrophy that progresses to dilation in a mouse model.

28 November 2018

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Human homozygous R403W mutant cardiac myosin presents disproportionate enhancement of mechanical and enzymatic properties.

28 November 2018

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Myosin from failing and non-failing human ventricles exhibit similar contractile properties

28 November 2018

1 reference

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Human cardiac myosin heavy chain isoforms in fetal and failing adult atria and ventricles

28 November 2018

1 reference

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A simple method for measuring the relative force exerted by myosin on actin filaments in the in vitro motility assay: evidence that tropomyosin and troponin increase force in single thin filaments

28 November 2018

1 reference

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Electrophoretic separation and quantitation of cardiac myosin heavy chain isoforms in eight mammalian species

28 November 2018

1 reference

12 December 2020

Cardiac V1 and V3 myosins differ in their hydrolytic and mechanical activities in vitro

1 reference

12 December 2020

Factors affecting movement of F-actin filaments propelled by skeletal muscle heavy meromyosin

1 reference

12 December 2020

Cardiac myosin isoforms from different species have unique enzymatic and mechanical properties

1 reference

12 December 2020

Smooth, cardiac and skeletal muscle myosin force and motion generation assessed by cross-bridge mechanical interactions in vitro

1 reference

12 December 2020

Calponin decreases the rate of cross-bridge cycling and increases maximum force production by smooth muscle myosin in an in vitro motility assay

1 reference

12 December 2020

Force-velocity relations in mammalian heart muscle

1 reference

12 December 2020

Expression of the cardiac ventricular alpha- and beta-myosin heavy chain genes is developmentally and hormonally regulated

1 reference

12 December 2020

[33] Assays for actin sliding movement over myosin-coated surfaces

1 reference

12 December 2020

The in vitro motility activity of beta-cardiac myosin depends on the nature of the beta-myosin heavy chain gene mutation in hypertrophic cardiomyopathy

1 reference

12 December 2020

10.1016/J.CELREP.2015.04.006

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25937279%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

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7 March 2020

PubMed publication ID

25937279

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25937279%20AND%20SRC:MED&resulttype=core&format=json