Methotrexate-mediated activation of an AMPK-CREB-dependent pathway: a novel mechanism for vascular protection in chronic systemic inflammation (Q27320563)

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English	Methotrexate-mediated activation of an AMPK-CREB-dependent pathway: a novel mechanism for vascular protection in chronic systemic inflammation	scientific article

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scholarly article

1 reference

Europe PubMed Central

26 June 2017

Methotrexate-mediated activation of an AMPK-CREB-dependent pathway: a novel mechanism for vascular protection in chronic systemic inflammation (English)

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Europe PubMed Central

26 June 2017

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systemic inflammation

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based on heuristic

inferred from title

author name string

C C Thornton

1

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Europe PubMed Central

26 June 2017

F Al-Rashed

2

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Europe PubMed Central

26 June 2017

D Calay

3

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Europe PubMed Central

26 June 2017

G M Birdsey

4

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Europe PubMed Central

26 June 2017

A Bauer

5

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Europe PubMed Central

26 June 2017

H Mylroie

6

1 reference

Europe PubMed Central

26 June 2017

B J Morley

7

1 reference

Europe PubMed Central

26 June 2017

A M Randi

8

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Europe PubMed Central

26 June 2017

D O Haskard

9

1 reference

Europe PubMed Central

26 June 2017

J J Boyle

10

1 reference

Europe PubMed Central

26 June 2017

J C Mason

11

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Europe PubMed Central

26 June 2017

language of work or name

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publication date

9 January 2015

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Europe PubMed Central

26 June 2017

Annals of the Rheumatic Diseases

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Europe PubMed Central

26 June 2017

75

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Europe PubMed Central

26 June 2017

439-448

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Europe PubMed Central

26 June 2017

2

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Europe PubMed Central

26 June 2017

AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling

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21 March 2017

Transcriptional regulation by the phosphorylation-dependent factor CREB

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4752671

21 March 2017

Transcriptional activation of the human manganese superoxide dismutase gene mediated by tetradecanoylphorbol acetate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4752671

21 March 2017

Methotrexate promotes glucose uptake and lipid oxidation in skeletal muscle via AMPK activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4752671

28 September 2017

Rationale and design of the Cardiovascular Inflammation Reduction Trial: a test of the inflammatory hypothesis of atherothrombosis

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28 September 2017

Metabolism of inflammation limited by AMPK and pseudo-starvation

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28 September 2017

Treatment with methotrexate inhibits atherogenesis in cholesterol-fed rabbits

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28 September 2017

Systematic review and meta-analysis of methotrexate use and risk of cardiovascular disease

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28 September 2017

Compound C stimulates heme oxygenase-1 gene expression via the Nrf2-ARE pathway to preserve human endothelial cell survival

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28 September 2017

Cardiac-specific overexpression of dominant-negative CREB leads to increased mortality and mitochondrial dysfunction in female mice

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28 September 2017

Effects of folic acid supplementation on serum folate and plasma homocysteine concentrations in older adults: a dose-response trial

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28 September 2017

Activation of AMP-activated protein kinase alpha1 alleviates endothelial cell apoptosis by increasing the expression of anti-apoptotic proteins Bcl-2 and survivin

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4752671

28 September 2017

AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes

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28 September 2017

CREB downregulation in vascular disease: a common response to cardiovascular risk

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4752671

28 September 2017

Activation and signaling by the AMP-activated protein kinase in endothelial cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4752671

28 September 2017

Regulation of superoxide dismutase genes: implications in disease

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28 September 2017

Atheroprotective effects of methotrexate on reverse cholesterol transport proteins and foam cell transformation in human THP-1 monocyte/macrophages

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4752671

28 September 2017

Suppression of the JNK pathway by induction of a metabolic stress response prevents vascular injury and dysfunction.

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28 September 2017

AMP-activated protein kinase phosphorylates transcription factors of the CREB family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4752671

28 September 2017

Methotrexate enhances the antianabolic and antiproliferative effects of 5-aminoimidazole-4-carboxamide riboside.

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28 September 2017

Methotrexate modulates the kinetics of adenosine in humans in vivo

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28 September 2017

AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform.

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28 September 2017

The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.

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28 September 2017

(NZW x BXSB)F1 hybrid. A model of acute lupus and coronary vascular disease with myocardial infarction

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28 September 2017

Quantitative analysis of myocardial infarction in (NZW x BXSB)F1 hybrid mice with systemic lupus erythematosus and small coronary artery disease

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4752671

28 September 2017

Methotrexate inhibits neutrophil function by stimulating adenosine release from connective tissue cells

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28 September 2017

Anticardiolipin antibodies in NZW x BXSB F1 mice. A model of antiphospholipid syndrome

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Degenerative vascular disease and myocardial infarction in mice with lupus-like syndrome

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28 September 2017

Total and free methotrexate pharmacokinetics, with and without piroxicam, in rheumatoid arthritis patients.

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31 May 2018

Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells

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21 January 2018

Methotrexate and mortality in patients with rheumatoid arthritis: a prospective study

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21 January 2018

Methotrexate--how does it really work?

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21 January 2018

Nimesulide improves the disease modifying anti-rheumatic profile of methotrexate in mice with collagen-induced arthritis.

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21 January 2018

Mitochondrial integrity and function in atherogenesis

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https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2014-206305

21 January 2018

AMPKalpha1 regulates the antioxidant status of vascular endothelial cells.

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21 January 2018

Methotrexate effects in patients with rheumatoid arthritis with cardiovascular comorbidity

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21 January 2018

Chronic inflammation and coronary microvascular dysfunction in patients without risk factors for coronary artery disease.

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21 January 2018

Genome-wide analysis of CREB target genes reveals a core promoter requirement for cAMP responsiveness

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21 January 2018

Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells

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28 November 2018

Effects of disease modifying anti-rheumatic drugs on subclinical atherosclerosis and endothelial dysfunction which has been detected in early rheumatoid arthritis: 1-year follow-up study

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Analysis of vascular lesions in murine SLE. I. Association with serologic abnormalities

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Effect of methotrexate treatment on the onset of autoimmune kidney disease in lupus mice

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Adenosine inhibits cytokine release and expression of adhesion molecules by activated human endothelial cells

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Identifiers

10.1136/ANNRHEUMDIS-2014-206305

1 reference

Europe PubMed Central

26 June 2017

OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

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Europe PubMed Central

26 June 2017

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