A conserved CXXC motif in CD3epsilon is critical for T cell development and TCR signaling (Q27325064)

5

0 references

John Kappler

6

object named as

John W Kappler

0 references

Janice White

4

object named as

Janice White

0 references

Dean Becker

2

object named as

Dean Becker

0 references

author name string

Yibing Wang

1

0 references

Tibor Vass

Creative Commons Attribution 4.0 International

3

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language of work or name

English

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publication date

December 2009

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published in

PLOS Biology

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volume

7

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issue

12

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page(s)

e1000253

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copyright license

start time

1 December 2009

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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21 March 2017

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Three-dimensional segregation of supramolecular activation clusters in T cells

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How TCRs bind MHCs, peptides, and coreceptors

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The alphabeta T cell receptor is an anisotropic mechanosensor.

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A membrane-proximal tetracysteine motif contributes to assembly of CD3deltaepsilon and CD3gammaepsilon dimers with the T cell receptor.

28 September 2017

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In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brain

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The CD3epsilon proline-rich sequence, and its interaction with Nck, is not required for T cell development and function

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A role for the alpha-chain connecting peptide motif in mediating TCR-CD8 cooperation

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Formation of supramolecular activation clusters on fresh ex vivo CD8+ T cells after engagement of the T cell antigen receptor and CD8 by antigen-presenting cells

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Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation

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Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells

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Function of the CD3 subunits of the pre-TCR and TCR complexes during T cell development.

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CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity

28 September 2017

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Specific requirement for CD3epsilon in T cell development.

28 September 2017

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Differential requirements for survival and proliferation of CD8 naïve or memory T cells

28 September 2017

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Ligands for the T-cell receptor: hard times for avidity models

28 September 2017

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2 June 2018

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T-cell antigen receptor (TCR)-alpha/beta heterodimer formation is a prerequisite for association of CD3-zeta 2 into functionally competent TCR.CD3 complexes

2 June 2018

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Extracellular signal-regulated kinases in T cells. Anti-CD3 and 4 beta-phorbol 12-myristate 13-acetate-induced phosphorylation and activation

2 June 2018

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2 June 2018

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Naive CD4(+) lymphocytes convert to anergic or memory-like cells in T cell-deprived recipients.

21 January 2018

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The Vβ-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice

21 January 2018

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Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.

21 January 2018

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Direct observation of ligand recognition by T cells.

21 January 2018

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Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity

21 January 2018

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The proline-rich sequence of CD3epsilon controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes

21 January 2018

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Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor.

21 January 2018

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Mechanistic basis of pre–T cell receptor–mediated autonomous signaling critical for thymocyte development

21 January 2018

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The Impact of Single Amino Acid Substitutions in CD3γ on the CD3ϵγ Interaction and T-Cell Receptor–CD3 Complex Formation

21 January 2018

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Leu 23 induction as an early marker of functional CD3/T cell antigen receptor triggering. Requirement for receptor cross-linking, prolonged elevation of intracellular [Ca++] and stimulation of protein kinase C.

21 January 2018

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A permissive geometry model for TCR–CD3 activation

27 November 2018

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12 December 2020

Assembly of the human T cell receptor-CD3 complex takes place in the endoplasmic reticulum and involves intermediary complexes between the CD3-gamma.delta.epsilon core and single T cell receptor alpha or beta chains

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12 December 2020

CD69 cell surface expression identifies developing thymocytes which audition for T cell antigen receptor-mediated positive selection

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12 December 2020

Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice

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12 December 2020

MHC Class II Molecules Are Not Required for Survival of Newly Generated CD4+ T Cells, but Affect Their Long-Term Life Span

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12 December 2020

Characterization of the region involved in CD3 pairwise interactions within the T cell receptor complex

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12 December 2020

Full Activation of the T Cell Receptor Requires Both Clustering and Conformational Changes at CD3

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12 December 2020

Disruption of extracellular interactions impairs T cell receptor-CD3 complex stability and signaling

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12 December 2020