A novel neutralizing antibody targeting pregnancy-associated plasma protein-a inhibits ovarian cancer growth and ascites accumulation in patient mouse tumorgrafts (Q27346392)

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English	A novel neutralizing antibody targeting pregnancy-associated plasma protein-a inhibits ovarian cancer growth and ascites accumulation in patient mouse tumorgrafts	scientific article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25695953%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

A novel neutralizing antibody targeting pregnancy-associated plasma protein-a inhibits ovarian cancer growth and ascites accumulation in patient mouse tumorgrafts (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25695953%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

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4

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1 March 2020

author name string

Marc A Becker

1

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1 March 2020

Paul Haluska

2

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1 March 2020

Laurie K Bale

3

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1 March 2020

Cheryl A Conover

5

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1 March 2020

publication date

18 February 2015

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1 March 2020

Molecular Cancer Therapeutics

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25695953%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

14

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1 March 2020

4

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1 March 2020

973-981

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PMC publication ID

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1 March 2020

Patient-derived tumor xenografts: transforming clinical samples into mouse models

1 reference

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21 March 2017

The insulin-like growth factor system in cancer

1 reference

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21 March 2017

Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394033

21 March 2017

NIH Image to ImageJ: 25 years of image analysis

1 reference

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21 March 2017

Mutational analysis of the proteolytic domain of pregnancy-associated plasma protein-A (PAPP-A): classification as a metzincin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394033

21 March 2017

The insulin-like growth factor insulin system in epithelial ovarian cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394033

21 March 2017

Pregnancy-associated plasma protein-A expression in human breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394033

29 September 2017

Can we unlock the potential of IGF-1R inhibition in cancer therapy?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394033

29 September 2017

Indirect targeting of IGF receptor signaling in vivo by substrate-selective inhibition of PAPP-A proteolytic activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394033

29 September 2017

Tumorgrafts as in vivo surrogates for women with ovarian cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394033

29 September 2017

Pharmacodynamic and antineoplastic activity of BI 836845, a fully human IGF ligand-neutralizing antibody, and mechanistic rationale for combination with rapamycin

1 reference

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29 September 2017

miRNA-214 is related to invasiveness of human non-small cell lung cancer and directly regulates alpha protein kinase 2 expression

1 reference

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29 September 2017

Identification of pregnancy-associated plasma protein A as a migration-promoting gene in malignant pleural mesothelioma cells: a potential therapeutic target

1 reference

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29 September 2017

Triggering the landslide: The tumor-promotional effects of myofibroblasts

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29 September 2017

Meeting the challenge of ascites in ovarian cancer: new avenues for therapy and research.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394033

29 September 2017

Insulin-like growth factor receptor inhibitors: baby or the bathwater?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394033

29 September 2017

Key questions and answers about pregnancy-associated plasma protein-A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394033

29 September 2017

Minireview: human ovarian cancer: biology, current management, and paths to personalizing therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394033

29 September 2017

The insulin and insulin-like growth factor receptor family in neoplasia: an update

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394033

29 September 2017

Targeting the insulin-like growth factor axis for the development of novel therapeutics in oncology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394033

29 September 2017

Ovarian cancer: Stat3, RhoA and IGF-IR as therapeutic targets

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394033

29 September 2017

Overexpression of pregnancy-associated plasma protein-A in ovarian cancer cells promotes tumor growth in vivo

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394033

29 September 2017

Frozen robust multiarray analysis (fRMA).

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29 September 2017

Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease.

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29 September 2017

Hyperactivation of the insulin-like growth factor receptor I signaling pathway is an essential event for cisplatin resistance of ovarian cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394033

29 September 2017

Metabolic consequences of pregnancy-associated plasma protein-A deficiency in mice: exploring possible relationship to the longevity phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394033

29 September 2017

Inhibition of the proteolytic activity of pregnancy-associated plasma protein-A by targeting substrate exosite binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394033

29 September 2017

Macrophages mediate inflammation-enhanced metastasis of ovarian tumors in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394033

29 September 2017

Value of insulin-like growth factor system markers in the assessment of growth hormone status

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394033

29 September 2017

Pregnancy-associated plasma protein-A (PAPP-A): a local regulator of IGF bioavailability through cleavage of IGFBPs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4394033

29 September 2017

The role of the IGF system in cancer growth and metastasis: overview and recent insights

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29 September 2017

Influence of the crosstalk between growth hormone and insulin signalling on the modulation of insulin sensitivity

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29 September 2017

Inhibition of insulin-like growth factor-I receptor (IGF-IR) signaling and tumor cell growth by a fully human neutralizing anti-IGF-IR antibody

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29 September 2017

Pregnancy-associated plasma protein-A (PAPP-A) expression and insulin-like growth factor binding protein-4 protease activity in normal and malignant ovarian surface epithelial cells.

1 reference

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29 September 2017

Genetic downregulation of pregnancy-associated plasma protein-A (PAPP-A) by bikunin reduces IGF-I-dependent Akt and ERK1/2 activation and subsequently reduces ovarian cancer cell growth, invasion and metastasis

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29 September 2017

Insulin-like growth factor system abnormalities in hepatitis C-associated osteosclerosis. Potential insights into increasing bone mass in adults

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29 September 2017

Evidence that the interaction between insulin-like growth factor (IGF)-II and IGF binding protein (IGFBP)-4 is essential for the action of the IGF-II-dependent IGFBP-4 protease

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2 June 2018

Insulin-like growth factor, insulin-like growth factor?binding protein-4, and pregnancy-associated plasma protein-A gene expression in human granulosa cell tumors

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27 November 2018

The insulin-like growth factor-I receptor gene: a downstream target for oncogene and tumor suppressor action.

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27 November 2018

Pregnancy-associated plasma protein a gene expression as a target of inflammatory cytokines.

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27 November 2018

Functional insulin receptors on human epithelial ovarian carcinoma cells: implications for IGF-II mitogenic signaling

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27 November 2018

IGF-I in epithelial ovarian cancer and its role in disease progression

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12 December 2020

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10.1158/1535-7163.MCT-14-0880

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1 March 2020

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1 March 2020

PubMed publication ID

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Europe PubMed Central

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1 March 2020

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